Howard Allan Rockman, MD

Professor of Medicine
Edward S. Orgain Distinguished Professor of Cardiology, in the School of Medicine
Professor in Cell Biology
Campus mail 226 Clin Res Lab Bldg, Duke Box 102151, Durham, NC 27710
Phone (919) 668-2520
Email address h.rockman@duke.edu

Rockman Lab: Molecular Mechanisms of Hypertrophy and Heart Failure

Overall Research Direction: The major focus of this laboratory is to understand the molecular mechanisms of hypertrophy and heart failure. My laboratory uses a strategy that combines state of the art molecular techniques to generate transgenic and gene targeted mouse models, combined with sophisticated physiologic measures of in vivo cardiac function. In this manner, candidate molecules are either selectively overexpressed in the mouse heart or genes ablated followed by an in-depth analysis of the physiological phenotype. To model human cardiac disease, we have created several models of cardiac overload in the mouse using both microsurgical techniques and genetic models of cardiac dysfunction.

Areas of Research
1) Signaling: G protein-coupled receptor signaling in hypertrophy and heart failure focusing on the concept of biased signaling of 7 transmembrane receptors.

2) Molecular physiology: In depth physiological analysis of cardiac function in genetically altered mice to understand the role of G protein-coupled receptor signaling pathways on the development of heart failure in vivo.

Education and Training

  • Cardiology Fellow, Medicine, University of California - San Diego, 1987 - 1991
  • Medical Resident, Medicine, Montreal General Hospital (Canada), 1984 - 1987
  • M.D., McGill University (Canada), 1983

Publications

Rajagopal, Sudarshan, Jeff Kovacs, Cristian Badea, G Allan Johnson, Howard A. Rockman, Claude A. Piantadosi, and Robert J. Lefkowitz. “BETA-ARRESTINS REGULATE SIGNALING BY BONE MORPHOGENETIC PROTEIN TYPE II RECEPTOR IN PULMONARY ARTERIAL HYPERTENSION.” Journal of the American College of Cardiology 57, no. 14 (April 2011): E2046–E2046. https://doi.org/10.1016/s0735-1097(11)62046-9.

Full Text

Grotegut, Chad A., Liping Feng, Lan Mao, R Phillips Heine, Amy P. Murtha, and Howard A. Rockman. “β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration.” Am J Physiol Endocrinol Metab 300, no. 3 (March 2011): E468–77. https://doi.org/10.1152/ajpendo.00390.2010.

PMID
21139074
Full Text

Patel, Chetan B., Nabila Noor, and Howard A. Rockman. “Functional selectivity in adrenergic and angiotensin signaling systems.” Mol Pharmacol 78, no. 6 (December 2010): 983–92. https://doi.org/10.1124/mol.110.067066.

PMID
20855464
Full Text

Alexander, Kevin M., Supachoke Mangmool, Chetan B. Patel, Kunhong Xiao, and Howard A. Rockman. “Phosphoinositde 3-Kinase Regulates beta 2-Adrenergic Receptor Stimulated Epidermal Growth Factor Receptor Transactivation.” Circulation 122, no. 21 (November 23, 2010).

Scholars@Duke

Tilley, Douglas G., Anny D. Nguyen, and Howard A. Rockman. “Troglitazone stimulates beta-arrestin-dependent cardiomyocyte contractility via the angiotensin II type 1A receptor.” Biochem Biophys Res Commun 396, no. 4 (June 11, 2010): 921–26. https://doi.org/10.1016/j.bbrc.2010.05.023.

PMID
20460106
Full Text

Rakesh, Kriti, ByungSu Yoo, Il-Man Kim, Natasha Salazar, Ki-Seok Kim, and Howard A. Rockman. “beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress.” Sci Signal 3, no. 125 (June 8, 2010): ra46. https://doi.org/10.1126/scisignal.2000769.

PMID
20530803
Full Text

Kim, Byung-Eun, Michelle L. Turski, Yasuhiro Nose, Michelle Casad, Howard A. Rockman, and Dennis J. Thiele. “Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs.” Cell Metab 11, no. 5 (May 5, 2010): 353–63. https://doi.org/10.1016/j.cmet.2010.04.003.

PMID
20444417
Full Text

Mangmool, Supachoke, Arun K. Shukla, and Howard A. Rockman. “beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation.” J Cell Biol 189, no. 3 (May 3, 2010): 573–87. https://doi.org/10.1083/jcb.200911047.

PMID
20421423
Full Text

Kim, Il-Man, Matthew J. Wolf, and Howard A. Rockman. “Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand.” Circ Res 106, no. 7 (April 16, 2010): 1233–43. https://doi.org/10.1161/CIRCRESAHA.109.213785.

PMID
20203305
Full Text

Pages