Howard Allan Rockman, MD

Professor of Medicine
Edward S. Orgain Professor of Cardiology, in the School of Medicine
Professor in Molecular Genetics and Microbiology
Professor in Cell Biology
Campus mail 226 Clin Res Lab Bldg, Durham, NC 27710
Phone (919) 668-2520
Email address h.rockman@duke.edu

Rockman Lab: Molecular Mechanisms of Hypertrophy and Heart Failure

Overall Research Direction: The major focus of this laboratory is to understand the molecular mechanisms of hypertrophy and heart failure. My laboratory uses a strategy that combines state of the art molecular techniques to generate transgenic and gene targeted mouse models, combined with sophisticated physiologic measures of in vivo cardiac function. In this manner, candidate molecules are either selectively overexpressed in the mouse heart or ablated by homologous recombination, which is followed by an in-depth analysis of the physiological phenotype. To model human cardiac disease, we have created several models of cardiac overload in the mouse using both microsurgical techniques and genetic models of cardiac dysfunction.

Areas of Research
1) Signaling: G protein-coupled receptor signaling in hypertrophy and heart failure focusing on the concept of biased signaling of 7 transmembrane receptors.

2) Molecular physiology: In depth physiological analysis of cardiac function in genetically altered mice to understand the role of G protein-coupled receptor signaling pathways on the development of heart failure in vivo.

3) Deletion screens in Drosophila: To detect novel genes important for cardiac function in the adult fly .

Education and Training

  • Cardiology Fellow, Medicine, University of California at San Diego, 1987 - 1991
  • Medical Resident, Medicine, Montreal General Hospital, 1984 - 1987
  • M.D., McGill University (Canada), 1983

Publications

Curcio, A, Noma, T, Naga Prasad, SV, Wolf, MJ, Lemaire, A, Perrino, C, Mao, L, and Rockman, HA. "Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling." Am J Physiol Heart Circ Physiol 291, no. 4 (October 2006): H1754-H1760.

PMID
16699071
Full Text

Seubert, JM, Sinal, CJ, Graves, J, DeGraff, LM, Bradbury, JA, Lee, CR, Goralski, K, Carey, MA, Luria, A, Newman, JW, Hammock, BD, Falck, JR, Roberts, H, Rockman, HA, Murphy, E, and Zeldin, DC. "Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function." Circ Res 99, no. 4 (August 18, 2006): 442-450.

PMID
16857962
Full Text

Gurley, SB, Allred, A, Le, TH, Griffiths, R, Mao, L, Philip, N, Haystead, TA, Donoghue, M, Breitbart, RE, Acton, SL, Rockman, HA, and Coffman, TM. "Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice." J Clin Invest 116, no. 8 (August 2006): 2218-2225.

PMID
16878172
Full Text

Perrino, C, Rockman, HA, and Chiariello, M. "Targeted inhibition of phosphoinositide 3-kinase activity as a novel strategy to normalize beta-adrenergic receptor function in heart failure." Vascul Pharmacol 45, no. 2 (August 2006): 77-85. (Review)

PMID
16807128
Full Text

Perrino, C, Naga Prasad, SV, Mao, L, Noma, T, Yan, Z, Kim, H-S, Smithies, O, and Rockman, HA. "Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction." J Clin Invest 116, no. 6 (June 2006): 1547-1560.

PMID
16741575
Full Text

Tachibana, H, Perrino, C, Takaoka, H, Davis, RJ, Naga Prasad, SV, and Rockman, HA. "JNK1 is required to preserve cardiac function in the early response to pressure overload." Biochem Biophys Res Commun 343, no. 4 (May 19, 2006): 1060-1066.

PMID
16579967
Full Text

Tilley, DG, and Rockman, HA. "Role of beta-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment." Expert Rev Cardiovasc Ther 4, no. 3 (May 2006): 417-432. (Review)

PMID
16716102
Full Text

Volovyk, ZM, Wolf, MJ, Prasad, SVN, and Rockman, HA. "Agonist-stimulated beta-adrenergic receptor internalization requires dynamic cytoskeletal actin turnover." J Biol Chem 281, no. 14 (April 7, 2006): 9773-9780.

PMID
16461348
Full Text

Perrino, C, and Rockman, HA. "GATA4 and the two sides of gene expression reprogramming." Circ Res 98, no. 6 (March 31, 2006): 715-716.

PMID
16574910
Full Text

Wolf, MJ, Amrein, H, Izatt, JA, Choma, MA, Reedy, MC, and Rockman, HA. "Drosophila as a model for the identification of genes causing adult human heart disease." Proc Natl Acad Sci U S A 103, no. 5 (January 31, 2006): 1394-1399.

PMID
16432241
Full Text

Pages