Howard Allan Rockman, MD

Professor of Medicine
Edward S. Orgain Distinguished Professor of Cardiology, in the School of Medicine
Professor in Cell Biology
Campus mail 226 Clin Res Lab Bldg, Duke Box 102151, Durham, NC 27710
Phone (919) 668-2520
Email address h.rockman@duke.edu

Rockman Lab: Molecular Mechanisms of Hypertrophy and Heart Failure

Overall Research Direction: The major focus of this laboratory is to understand the molecular mechanisms of hypertrophy and heart failure. My laboratory uses a strategy that combines state of the art molecular techniques to generate transgenic and gene targeted mouse models, combined with sophisticated physiologic measures of in vivo cardiac function. In this manner, candidate molecules are either selectively overexpressed in the mouse heart or genes ablated followed by an in-depth analysis of the physiological phenotype. To model human cardiac disease, we have created several models of cardiac overload in the mouse using both microsurgical techniques and genetic models of cardiac dysfunction.

Areas of Research
1) Signaling: G protein-coupled receptor signaling in hypertrophy and heart failure focusing on the concept of biased signaling of 7 transmembrane receptors.

2) Molecular physiology: In depth physiological analysis of cardiac function in genetically altered mice to understand the role of G protein-coupled receptor signaling pathways on the development of heart failure in vivo.

Education and Training

  • Cardiology Fellow, Medicine, University of California - San Diego, 1987 - 1991
  • Medical Resident, Medicine, Montreal General Hospital (Canada), 1984 - 1987
  • M.D., McGill University (Canada), 1983

Publications

Yoo, ByungSu, Kriti Rakesh, Lan Mao, and Howard A. Rockman. “Mechanical Stretch Activates beta-arrestin-mediated Signaling of the AT1 Receptor.” In Circulation, 120:S866–S866. LIPPINCOTT WILLIAMS & WILKINS, 2009.

Scholars@Duke

Mangmool, Supachoke, Weili Zou, Lan Mao, and Howard A. Rockman. “beta-Arrestin-Dependent Activation of Ca2+/Calmodulin-Dependent Kinase II Following beta(1)-Adrenergic Receptor Activation.” In Circulation, 120:S1147–S1147. LIPPINCOTT WILLIAMS & WILKINS, 2009.

Scholars@Duke

Kim, Il-Man, Matthew J. Wolf, and Howard A. Rockman. “Gene Deletion Screen for Cardiomyopathy in Adult Drosophila Identifies Weary (Wry): A New Notch Ligand.” In Circulation, 120:S743–S743. LIPPINCOTT WILLIAMS & WILKINS, 2009.

Scholars@Duke

Patel, Chetan B., Priyesh A. Patel, Stephan G. Frangakis, Minyong Chen, Sudha K. Shenoy, Robert J. Lefkowitz, and Howard A. Rockman. “A Modified beta 1-adrenergic Receptor Demonstrates Bias Towards G Protein Receptor Kinase Phosphorylation.” In Circulation, 120:S800–801. LIPPINCOTT WILLIAMS & WILKINS, 2009.

Scholars@Duke

Yoo, ByungSu, Anthony Lemaire, Supachoke Mangmool, Matthew J. Wolf, Antonio Curcio, Lan Mao, and Howard A. Rockman. “Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction.” Am J Physiol Heart Circ Physiol 297, no. 4 (October 2009): H1377–86. https://doi.org/10.1152/ajpheart.00504.2009.

PMID
19633206
Full Text

Wheeler, Ferrin C., Hao Tang, Odessa A. Marks, Tracy N. Hadnott, Pei-Lun Chu, Lan Mao, Howard A. Rockman, and Douglas A. Marchuk. “Tnni3k modifies disease progression in murine models of cardiomyopathy.” Plos Genet 5, no. 9 (September 2009): e1000647. https://doi.org/10.1371/journal.pgen.1000647.

PMID
19763165
Full Text

Tilley, Douglas G., Il-Man Kim, Priyesh A. Patel, Jonathan D. Violin, and Howard A. Rockman. “beta-Arrestin mediates beta1-adrenergic receptor-epidermal growth factor receptor interaction and downstream signaling.” J Biol Chem 284, no. 30 (July 24, 2009): 20375–86. https://doi.org/10.1074/jbc.M109.005793.

PMID
19509284
Full Text

Pandya, Kumar, Kristine Porter, Howard A. Rockman, and Oliver Smithies. “Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain.” Eur J Heart Fail 11, no. 7 (July 2009): 648–52. https://doi.org/10.1093/eurjhf/hfp073.

PMID
19553396
Full Text

Fernandez, Liliana, Douglas A. Marchuk, Jennifer L. Moran, David R. Beier, and Howard A. Rockman. “An N-ethyl-N-nitrosourea mutagenesis recessive screen identifies two candidate regions for murine cardiomyopathy that map to chromosomes 1 and 15.” Mamm Genome 20, no. 5 (May 2009): 296–304. https://doi.org/10.1007/s00335-009-9184-7.

PMID
19387734
Full Text

Lima, Brian, Gregory K. W. Lam, Liang Xie, Diana L. Diesen, Nestor Villamizar, Jeffrey Nienaber, Emily Messina, et al. “Endogenous S-nitrosothiols protect against myocardial injury.” Proc Natl Acad Sci U S A 106, no. 15 (April 14, 2009): 6297–6302. https://doi.org/10.1073/pnas.0901043106.

PMID
19325130
Full Text

Pages