Howard Allan Rockman, MD

Professor of Medicine
Edward S. Orgain Professor of Cardiology, in the School of Medicine
Professor in Molecular Genetics and Microbiology
Professor in Cell Biology
Campus mail 226 Clin Res Lab Bldg, Durham, NC 27710
Phone (919) 668-2520
Email address h.rockman@duke.edu

Rockman Lab: Molecular Mechanisms of Hypertrophy and Heart Failure

Overall Research Direction: The major focus of this laboratory is to understand the molecular mechanisms of hypertrophy and heart failure. My laboratory uses a strategy that combines state of the art molecular techniques to generate transgenic and gene targeted mouse models, combined with sophisticated physiologic measures of in vivo cardiac function. In this manner, candidate molecules are either selectively overexpressed in the mouse heart or ablated by homologous recombination, which is followed by an in-depth analysis of the physiological phenotype. To model human cardiac disease, we have created several models of cardiac overload in the mouse using both microsurgical techniques and genetic models of cardiac dysfunction.

Areas of Research
1) Signaling: G protein-coupled receptor signaling in hypertrophy and heart failure focusing on the concept of biased signaling of 7 transmembrane receptors.

2) Molecular physiology: In depth physiological analysis of cardiac function in genetically altered mice to understand the role of G protein-coupled receptor signaling pathways on the development of heart failure in vivo.

3) Deletion screens in Drosophila: To detect novel genes important for cardiac function in the adult fly .

Education and Training

  • Cardiology Fellow, Medicine, University of California at San Diego, 1987 - 1991
  • Medical Resident, Medicine, Montreal General Hospital, 1984 - 1987
  • M.D., McGill University (Canada), 1983

Publications

Salazar, NC, Chen, J, and Rockman, HA. "Cardiac GPCRs: GPCR signaling in healthy and failing hearts." Biochim Biophys Acta 1768, no. 4 (April 2007): 1006-1018. (Review)

PMID
17376402
Full Text

Donahue, MP, Marchuk, DA, and Rockman, HA. "Reply." Journal of the American College of Cardiology 49, no. 10 (2007): 1106-1107.

Full Text

Rajagopal, K, Whalen, EJ, Violin, JD, Stiber, JA, Rosenberg, PB, Premont, RT, Coffman, TM, Rockman, HA, and Lefkowitz, RJ. "Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes." Proc Natl Acad Sci U S A 103, no. 44 (October 31, 2006): 16284-16289.

PMID
17060617
Full Text

Donahue, MP, Marchuk, DA, and Rockman, HA. "Redefining heart failure: the utility of genomics." J Am Coll Cardiol 48, no. 7 (October 3, 2006): 1289-1298. (Review)

PMID
17010784
Full Text

Curcio, A, Noma, T, Naga Prasad, SV, Wolf, MJ, Lemaire, A, Perrino, C, Mao, L, and Rockman, HA. "Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling." Am J Physiol Heart Circ Physiol 291, no. 4 (October 2006): H1754-H1760.

PMID
16699071
Full Text

Seubert, JM, Sinal, CJ, Graves, J, DeGraff, LM, Bradbury, JA, Lee, CR, Goralski, K, Carey, MA, Luria, A, Newman, JW, Hammock, BD, Falck, JR, Roberts, H, Rockman, HA, Murphy, E, and Zeldin, DC. "Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function." Circ Res 99, no. 4 (August 18, 2006): 442-450.

PMID
16857962
Full Text

Gurley, SB, Allred, A, Le, TH, Griffiths, R, Mao, L, Philip, N, Haystead, TA, Donoghue, M, Breitbart, RE, Acton, SL, Rockman, HA, and Coffman, TM. "Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice." J Clin Invest 116, no. 8 (August 2006): 2218-2225.

PMID
16878172
Full Text

Perrino, C, Rockman, HA, and Chiariello, M. "Targeted inhibition of phosphoinositide 3-kinase activity as a novel strategy to normalize beta-adrenergic receptor function in heart failure." Vascul Pharmacol 45, no. 2 (August 2006): 77-85. (Review)

PMID
16807128
Full Text

Perrino, C, Naga Prasad, SV, Mao, L, Noma, T, Yan, Z, Kim, H-S, Smithies, O, and Rockman, HA. "Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction." J Clin Invest 116, no. 6 (June 2006): 1547-1560.

PMID
16741575
Full Text

Tachibana, H, Perrino, C, Takaoka, H, Davis, RJ, Naga Prasad, SV, and Rockman, HA. "JNK1 is required to preserve cardiac function in the early response to pressure overload." Biochem Biophys Res Commun 343, no. 4 (May 19, 2006): 1060-1066.

PMID
16579967
Full Text

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