Howard Allan Rockman, MD

Professor of Medicine
Edward S. Orgain Distinguished Professor of Cardiology, in the School of Medicine
Professor in Cell Biology
Campus mail 226 Clin Res Lab Bldg, Duke Box 102151, Durham, NC 27710
Phone (919) 668-2520
Email address h.rockman@duke.edu

Rockman Lab: Molecular Mechanisms of Hypertrophy and Heart Failure

Overall Research Direction: The major focus of this laboratory is to understand the molecular mechanisms of hypertrophy and heart failure. My laboratory uses a strategy that combines state of the art molecular techniques to generate transgenic and gene targeted mouse models, combined with sophisticated physiologic measures of in vivo cardiac function. In this manner, candidate molecules are either selectively overexpressed in the mouse heart or genes ablated followed by an in-depth analysis of the physiological phenotype. To model human cardiac disease, we have created several models of cardiac overload in the mouse using both microsurgical techniques and genetic models of cardiac dysfunction.

Areas of Research
1) Signaling: G protein-coupled receptor signaling in hypertrophy and heart failure focusing on the concept of biased signaling of 7 transmembrane receptors.

2) Molecular physiology: In depth physiological analysis of cardiac function in genetically altered mice to understand the role of G protein-coupled receptor signaling pathways on the development of heart failure in vivo.

Education and Training

  • Cardiology Fellow, Medicine, University of California - San Diego, 1987 - 1991
  • Medical Resident, Medicine, Montreal General Hospital (Canada), 1984 - 1987
  • M.D., McGill University (Canada), 1983

Publications

Fernandez, Liliana, Douglas A. Marchuk, Jennifer L. Moran, David R. Beier, and Howard A. Rockman. “An N-ethyl-N-nitrosourea mutagenesis recessive screen identifies two candidate regions for murine cardiomyopathy that map to chromosomes 1 and 15.” Mamm Genome 20, no. 5 (May 2009): 296–304. https://doi.org/10.1007/s00335-009-9184-7.

PMID
19387734
Full Text

Lima, Brian, Gregory K. W. Lam, Liang Xie, Diana L. Diesen, Nestor Villamizar, Jeffrey Nienaber, Emily Messina, et al. “Endogenous S-nitrosothiols protect against myocardial injury.” Proc Natl Acad Sci U S A 106, no. 15 (April 14, 2009): 6297–6302. https://doi.org/10.1073/pnas.0901043106.

PMID
19325130
Full Text

Acehan, Devrim, Zaza Khuchua, Riekelt H. Houtkooper, Ashim Malhotra, Johanna Kaufman, Frédéric M. Vaz, Mindong Ren, Howard A. Rockman, David L. Stokes, and Michael Schlame. “Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria.” Mitochondrion 9, no. 2 (April 2009): 86–95. https://doi.org/10.1016/j.mito.2008.12.001.

PMID
19114128
Full Text

Grotegut, Chad A., Amy P. Murtha, and Howard A. Rockman. “Beta-Arrestin Mediates Oxytocin Receptor Desensitization and MAPK Signaling Following Oxytocin Stimulation.” Reproductive Sciences 16, no. 3 (March 1, 2009): 104A-104A.

Scholars@Duke

Mehra, Mandeep R., Howard A. Rockman, and Barry H. Greenberg. “Highlights of the 2008 Scientific Sessions of the Heart Failure Society of America. Toronto, Ontario, Canada, September 20-23, 2008.” Journal of the American College of Cardiology 53, no. 6 (February 2009): 514–22. https://doi.org/10.1016/j.jacc.2008.11.003.

PMID
19195609
Full Text

Wolf, Matthew J., and Howard A. Rockman. “Drosophila melanogaster as a model system for genetics of postnatal cardiac function.” Drug Discov Today Dis Models 5, no. 3 (October 1, 2008): 117–23. https://doi.org/10.1016/j.ddmod.2009.02.002.

PMID
19802348
Full Text

Francois, Helene, Natalia Makhanova, Philip Ruiz, Jonathan Ellison, Lan Mao, Howard A. Rockman, and Thomas M. Coffman. “A role for the thromboxane receptor in L-NAME hypertension.” Am J Physiol Renal Physiol 295, no. 4 (October 2008): F1096–1102. https://doi.org/10.1152/ajprenal.00369.2007.

PMID
18684890
Full Text

Pages