Ian James Welsby, MBBS

Professor of Anesthesiology
Professor of Medicine
Campus mail 2301 Erwin Road, 5691H Hafs Building, Durham, NC 27710
Phone (919) 681-6752
Email address ian.welsby@duke.edu

As a practicing cardiothoracic anesthesiologist, I have contributed to the better understanding of the management and of perioperative thrombosis (particularly HIT). This has been as a Duke site PI for the Rare Thrombotic Diseases Consortium led by Dr T.L Ortel and a clinical collaborator with the basic and translational science approach to HIT led by Dr G Arepally. I have also championed novel approaches to dealing with perioperative HIT such as plasmaperesis.

Similarly, I have been a local leader in establishing management of transfusion approaches to major cardiac surgery including the novel introduction of autologous plateletpheresis to limit exposure to allogeneic platelet transfusions in this highly transfused population, identifying the transfusion requirements during thoracic aortic reconstruction and promoting use of a lower dose of rFVIIa use in this population, changing established clinical practice.

My research interests focus on perioperative transfusion and hematology concerns. Recently, Dr Kor (Mayo Clinic) and I received a multiple PI R-01 award to evaluate point-of-care/bedside washing of packed red blood cells to reduce perioperative lung injury. This novel repurposing of commonly available “cell-saver” technology is, for most surgical cases, the only practical means of delivering a washed product, and promises to be a critical advancement in perioperative transfusion medicine. I also have a longstanding interest in the rejuvenation of RBCs to normalize oxygen delivery capacity of transfused RBCs. Such a development will be of tremendous importance to transfusion practice, particularly for highly transfused populations. 

In summary, I have dedicated my research career to improving the outcome of patients undergoing cardiothoracic surgery, understanding perioperative coagulopathy, and optimizing transfusion practice. 

Education and Training

  • Anaesthetic Registrar, Anaesthetics, Royal London Hospital (United Kingdom), 1995 - 1995
  • Anaesthetic registrar, Anaesthetic, Royal London Hospital (United Kingdom), 1994 - 1995
  • Temporary Registrar, Anaesthetics, Royal London Hospital (United Kingdom), 1993 - 1994
  • Senior House Officer, Anesthetics, Royal London Hospital (United Kingdom), 1992 - 1993
  • Senior House Officer, Intensive Care, Royal London Hospital (United Kingdom), 1992 - 1992
  • Senior House Officer, Accident And Emergency, Royal London Hospital (United Kingdom), 1991 - 1992
  • House Officer, General And Vascular Surgery, Royal London Hospital (United Kingdom), 1991 - 1991
  • House Officer, Chest And General Medicine, Royal London Hospital (United Kingdom), 1990 - 1991
  • Anaesthetic Registrar, Anaesthetics, Royal London Hospital (United Kingdom), 1990 - 1990
  • M.B.B.S., University College London (United Kingdom), 1990

Publications

Evans, Brooke A., Andrea K. Ansari, Reed W. Kamyszek, Michele Salvagno, John Welsby, Matthew Fuller, and Ian Welsby. “Modulation of red blood cell oxygen affinity with a novel allosteric modifier of hemoglobin is additive to the Bohr effect.” Blood Cells Mol Dis 87 (March 2021): 102520. https://doi.org/10.1016/j.bcmd.2020.102520.

PMID
33242840
Full Text

Moreno-Duarte, Ingrid, Mary Cooter, Oluwatoyosi A. Onwuemene, Kamrouz Ghadimi, and Ian J. Welsby. “Clinical outcomes of cardiac surgery patients undergoing therapeutic plasma exchange for heparin-induced thrombocytopenia.” Vox Sang 116, no. 2 (February 2021): 217–24. https://doi.org/10.1111/vox.13008.

PMID
32965049
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Corwin, Howard L., Aryeh Shander, Bruce Speiss, Manuel Muñoz, David Faraoni, Domenico Calcaterra, Ian Welsby, et al. “Management of Perioperative Iron Deficiency in Cardiac Surgery: A Modified RAND Delphi Study.” The Annals of Thoracic Surgery, December 17, 2020. https://doi.org/10.1016/j.athoracsur.2020.11.031.

PMID
33345781
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Daughety, Molly M., Andrew Morgan, Erin Frost, Chester Kao, Joyce Hwang, Rachel Tobin, Bhavik Patel, Matthew Fuller, Ian Welsby, and Thomas L. Ortel. “COVID-19 associated coagulopathy: Thrombosis, hemorrhage and mortality rates with an escalated-dose thromboprophylaxis strategy.” Thromb Res 196 (December 2020): 483–85. https://doi.org/10.1016/j.thromres.2020.10.004.

PMID
33091700
Full Text

Daughety, Molly, Thomas L. Ortel, Erin Frost, Andrew Morgan, Chester Kao, Joyce Hwang, Bhavik Patel, and Ian J. Welsby. “COVID-19 Associated Coagulopathy: Thrombosis, Hemorrhage and Mortality Rates with an Escalated-Thromboprophylaxis Strategy.” In Blood, 136:23–24. American Society of Hematology, 2020. https://doi.org/10.1182/blood-2020-142944.

Full Text

Bottiger, Brandi A., Jacob Klapper, Angela Pollak, and Ian Welsby. “When Therapy Is Confounded With Approach: Retrospective Studies of Transfusion-Related Outcomes After Lung Transplantation.” J Cardiothorac Vasc Anesth 34, no. 11 (November 2020): 3021–23. https://doi.org/10.1053/j.jvca.2020.07.064.

PMID
32828654
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Kamyszek, Reed W., Matthew W. Foster, Brooke A. Evans, Keaton Stoner, Jessica Poisson, Amudan J. Srinivasan, J Will Thompson, M Arthur Moseley, Micah J. Mooberry, and Ian J. Welsby. “The effect of pathogen inactivation on cryoprecipitate: a functional and quantitative evaluation.” Blood Transfus 18, no. 6 (November 2020): 454–64. https://doi.org/10.2450/2020.0077-20.

PMID
33000752
Full Text

Barac, Yaron D., Jacob Klapper, Angela Pollack, Jessica Poisson, Ian Welsby, M. G. Hartwig, and Brandi Bottiger. “Anticoagulation Strategies in the Perioperative Period for Lung Transplant.” Ann Thorac Surg 110, no. 1 (July 2020): e23–25. https://doi.org/10.1016/j.athoracsur.2019.11.056.

PMID
31981503
Full Text

Evans, Brooke A., Andrea K. Ansari, Amudan J. Srinivasan, Reed W. Kamyszek, Keaton C. Stoner, Matthew Fuller, Jessica L. Poisson, and Ian J. Welsby. “Rejuvenation solution as an adjunct cold storage solution maintains physiological haemoglobin oxygen affinity during early-storage period of red blood cells.” Vox Sang 115, no. 5 (July 2020): 388–94. https://doi.org/10.1111/vox.12910.

PMID
32166752
Full Text

Lopez Domowicz, Denise A., Ian Welsby, Charles R. Esther, Hongmei Zhu, Robert D. Marek, Grace Lee, Nirmish Shah, Jessica L. Poisson, and Tim J. McMahon. “Effects of repleting organic phosphates in banked erythrocytes on plasma metabolites and vasoactive mediators after red cell exchange transfusion in sickle cell disease.” Blood Transfus 18, no. 3 (May 2020): 200–207. https://doi.org/10.2450/2020.0237-19.

PMID
32203007
Full Text

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