J. Franklin Wharam, MBBCh

Professor of Medicine
Member of the Duke Cancer Institute
Campus mail Box 31256 Med Ctr, Durham, NC 27710
Phone (919) 684-8111
Email address james.wharam@duke.edu

Dr. Frank Wharam is a general internist and health policy researcher. He studies the impact of national and state policies on the health outcomes of chronically ill and vulnerable populations. His research often examines effects of health insurance benefit designs such as value-based, consumer-directed, and high-deductible health plans. Dr. Wharam also focuses on interventions that affect people with substance use disorders, diabetes, obesity, mental illness, and respiratory diseases. Other interests include the adverse effects of wasteful health care spending on medical and non-medical outcomes. He has expertise in rigorous quasi-experiment research designs, causal inference in observational data, and large claims data analyses.

Dr. Wharam is core faculty member in the Margolis Center and Professor of Medicine in the Division of General Internal Medicine. He directs a new center devoted to analyzing large-scale health policy effects in order to inform a more efficient and equitable health care system.   

Dr. Wharam joins Duke after 17 years at the Harvard Medical School Department of Population Medicine. There he held the Martin Robison Delany endowed chair and was Director of the Division of Health Policy and Insurance Research. Before Harvard, he completed Internal Medicine residency at Duke in 2004. 

Education and Training

  • Fellowship, Medical Ethics, Harvard Medical School, 2005 - 2006
  • Fellowship, Internal Medicine, Harvard Medical School, 2004 - 2007
  • Residency, Internal Medicine, Duke University, 2001 - 2004
  • M.B.B.Ch., University College Dublin (Ireland), 2001

Publications

Ferrario, Alessandra, Fang Zhang, Dennis Ross-Degnan, J Frank Wharam, Martha L. Twaddle, and Anita K. Wagner. “Use of Palliative Care Among Commercially Insured Patients With Metastatic Cancer Between 2001 and 2016.” Jco Oncol Pract 18, no. 5 (May 2022): e677–87. https://doi.org/10.1200/OP.21.00516.

PMID
34986008
Full Text

Lowry, Kathryn P., Katherine A. Callaway, Janie M. Lee, Fang Zhang, Dennis Ross-Degnan, J Frank Wharam, Karla Kerlikowske, et al. “Trends in Annual Surveillance Mammography Participation Among Breast Cancer Survivors From 2004 to 2016.” J Natl Compr Canc Netw 20, no. 4 (April 2022): 379-386.e9. https://doi.org/10.6004/jnccn.2021.7081.

PMID
35390766
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Kan, Kristin, and Ruchi S. Gupta. “Controller Medication Use and Exacerbations for Children and Adults With Asthma in High-Deductible Health Plans.” In Pediatrics, 148:S54–S54. American Academy of Pediatrics (AAP), 2021. https://doi.org/10.1542/peds.2021-053843aaaa.

Full Text

Sinaiko, Anna D., Marema Gaye, Ann Chen Wu, Elizabeth Bambury, Fang Zhang, Xin Xu, J Frank Wharam, and Alison A. Galbraith. “Out-of-Pocket Spending for Asthma-Related Care Among Commercially Insured Patients, 2004-2016.” J Allergy Clin Immunol Pract 9, no. 12 (December 2021): 4324-4331.e7. https://doi.org/10.1016/j.jaip.2021.07.054.

PMID
34481128
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Wharam, J Frank, Jamie Wallace, Stephanie Argetsinger, Fang Zhang, Christine Y. Lu, Tomasz P. Stryjewski, Dennis Ross-Degnan, and Joseph P. Newhouse. “Diabetes Microvascular Disease Diagnosis and Treatment After High-Deductible Health Plan Enrollment.” Diabetes Care, September 29, 2021. https://doi.org/10.2337/dc21-0407.

PMID
34588211
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Garabedian, Laura F., Fang Zhang, Robert LeCates, Jamie Wallace, Dennis Ross-Degnan, and James F. Wharam. “Trends in high deductible health plan enrolment and spending among commercially insured members with and without chronic conditions: a Natural Experiment for Translation in Diabetes (NEXT-D2) Study.” Bmj Open 11, no. 9 (September 13, 2021): e044198. https://doi.org/10.1136/bmjopen-2020-044198.

PMID
34518242
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Chou, Shih-Chuan, Arthur S. Hong, Scott G. Weiner, and J Frank Wharam. “Impact of High-Deductible Health Plans on Emergency Department Patients With Nonspecific Chest Pain and Their Subsequent Care.” Circulation 144, no. 5 (August 3, 2021): 336–49. https://doi.org/10.1161/CIRCULATIONAHA.120.052501.

PMID
34176279
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Galbraith, Alison A., Dennis Ross-Degnan, Fang Zhang, Ann Chen Wu, Anna Sinaiko, Alon Peltz, Xin Xu, Jamie Wallace, and J Frank Wharam. “Controller Medication Use and Exacerbations for Children and Adults With Asthma in High-Deductible Health Plans.” Jama Pediatr 175, no. 8 (August 1, 2021): 807–16. https://doi.org/10.1001/jamapediatrics.2021.0747.

PMID
33970186
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Chou, Shih-Chuan, Arthur S. Hong, Scott G. Weiner, and J Frank Wharam. “High-deductible health plans and low-value imaging in the emergency department.” Health Serv Res 56, no. 4 (August 2021): 709–20. https://doi.org/10.1111/1475-6773.13569.

PMID
33025604
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Lu, Christine Y., Alisa B. Busch, Fang Zhang, Jeanne M. Madden, Matthew X. Callahan, Robert F. LeCates, Jamie Wallace, et al. “Impact of High-Deductible Health Plans on Medication Use Among Individuals With Bipolar Disorder.” Psychiatr Serv 72, no. 8 (August 1, 2021): 926–34. https://doi.org/10.1176/appi.ps.202000362.

PMID
33971720
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