James William Wisler, MD

Medical Instructor in the Department of Medicine

Campus mail 448 Jones Bldg, Durham, NC 27710

Phone (919) 684-4906

Email address jim.wisler@duke.edu

Education and Training

Cardiovascular Diseases Fellowship, Medicine, Duke University School of Medicine, 2011 - 2016
Internal Medicine Residency, Medicine, Duke University School of Medicine, 2009 - 2011
M.D., Ohio State University College of Medicine, 2009

Grants

Mechanistic studies of Mas receptor activation and its role in aortic aneurysm formation

Publications

Wisler, James W., Howard A. Rockman, and Robert J. Lefkowitz. “Biased G Protein-Coupled Receptor Signaling: Changing the Paradigm of Drug Discovery..” Circulation 137, no. 22 (May 29, 2018): 2315–17. https://doi.org/10.1161/CIRCULATIONAHA.117.028194.

PMID

29844068

Full Text

Rein, Lindsay Am, James W. Wisler, Jihee Kim, Barbara Theriot, LiYin Huang, Trevor Price, Haeyoon Yang, et al. “β-Arrestin2 mediates progression of murine primary myelofibrosis..” Jci Insight 2, no. 24 (December 21, 2017). https://doi.org/10.1172/jci.insight.98094.

PMID

29263312

Full Text

Kahsai, Alem W., James W. Wisler, Jungmin Lee, Seungkirl Ahn, Thomas J. Cahill Iii, S Moses Dennison, Dean P. Staus, et al. “Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor..” Nat Chem Biol 12, no. 9 (September 2016): 709–16. https://doi.org/10.1038/nchembio.2126.

PMID

27398998

Full Text

Rein, Lindsay A. M., James W. Wisler, Barbara S. Theriot, Li-Yin Huang, Richard T. Premont, and Robert J. Lefkowitz. “beta-arrestin2 Is Necessary for Development of MPLW515L Mutant Primary Myelofibrosis.” In Blood, Vol. 126. AMER SOC HEMATOLOGY, 2015.

Scholars@Duke

Wisler, James W., Emily M. Harris, Michael Raisch, Lan Mao, Jihee Kim, Howard A. Rockman, and Robert J. Lefkowitz. “The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome..” Am J Physiol Heart Circ Physiol 309, no. 9 (November 2015): H1516–27. https://doi.org/10.1152/ajpheart.00291.2015.

PMID

26371162

Full Text

Wisler, James W., and Richard C. Becker. “Antithrombotic therapy: new areas to understand efficacy and bleeding..” Expert Opin Ther Targets 18, no. 12 (December 2014): 1427–34. https://doi.org/10.1517/14728222.2014.953929.

PMID

25347453

Full Text

Wisler, James W., Kunhong Xiao, Alex R. B. Thomsen, and Robert J. Lefkowitz. “Recent developments in biased agonism..” Curr Opin Cell Biol 27 (April 2014): 18–24. https://doi.org/10.1016/j.ceb.2013.10.008.

PMID

24680426

Full Text

Wisler, James, Emily Harris, Michael Raisch, Lan Mao, Jihee Kim, Howard Rockman, and Robert Lefkowitz. “NON-CANONICAL ANGIOTENSIN II TYPE 1A RECEPTOR-MEDIATED, BETA-ARRESTIN2-DEPENDENT SIGNALING CONTRIBUTES TO THORACIC AORTIC ANEURYSM FORMATION IN A MURINE MODEL OF MARFAN SYNDROME.” In Journal of the American College of Cardiology, 63:A2148–A2148. Elsevier BV, 2014. https://doi.org/10.1016/s0735-1097(14)62151-3.

Full Text

Wisler, James W., and Richard C. Becker. “Emerging paradigms in arterial thrombosis..” J Thromb Thrombolysis 37, no. 1 (January 2014): 4–11. https://doi.org/10.1007/s11239-013-0965-1.

PMID

24046067

Full Text

Han, Sang-oh, Kunhong Xiao, Jihee Kim, Jiao-Hui Wu, James W. Wisler, Nobuhiro Nakamura, Neil J. Freedman, and Sudha K. Shenoy. “MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors..” J Cell Biol 199, no. 5 (November 26, 2012): 817–30. https://doi.org/10.1083/jcb.201208192.

PMID

23166351

Full Text

James William Wisler, MD

Education and Training

Grants

Publications

Pages