Cardiology

James William Wisler, MD

Medical Instructor in the Department of Medicine
Campus mail 448 Jones Bldg, Durham, NC 27710
Phone (919) 684-4906
Email address jim.wisler@duke.edu

Education and Training

  • Cardiovascular Diseases Fellowship, Medicine, Duke University School of Medicine, 2011 - 2016
  • Internal Medicine Residency, Medicine, Duke University School of Medicine, 2009 - 2011
  • M.D., Ohio State University College of Medicine, 2009

Grants

Publications

Wisler, JW, Rockman, HA, and Lefkowitz, RJ. "Biased G Protein-Coupled Receptor Signaling: Changing the Paradigm of Drug Discovery." Circulation 137, no. 22 (May 2018): 2315-2317.

PMID
29844068
Full Text

Rein, LA, Wisler, JW, Kim, J, Theriot, B, Huang, L, Price, T, Yang, H, Chen, M, Chen, W, Sipkins, D, Fedoriw, Y, Walker, JK, Premont, RT, and Lefkowitz, RJ. "β-Arrestin2 mediates progression of murine primary myelofibrosis." JCI insight 2, no. 24 (December 21, 2017).

PMID
29263312
Full Text

Kahsai, AW, Wisler, JW, Lee, J, Ahn, S, Cahill Iii, TJ, Dennison, SM, Staus, DP, Thomsen, ARB, Anasti, KM, Pani, B, Wingler, LM, Desai, H, Bompiani, KM, Strachan, RT, Qin, X, Alam, SM, Sullenger, BA, and Lefkowitz, RJ. "Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor." Nature Chemical Biology 12, no. 9 (September 2016): 709-716.

PMID
27398998
Full Text

Rein, LAM, Wisler, JW, Theriot, BS, Huang, L-Y, Premont, RT, and Lefkowitz, RJ. "beta-arrestin2 Is Necessary for Development of MPLW515L Mutant Primary Myelofibrosis." December 3, 2015.

Scholars@Duke

Wisler, JW, Harris, EM, Raisch, M, Mao, L, Kim, J, Rockman, HA, and Lefkowitz, RJ. "The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome." American Journal of Physiology. Heart and Circulatory Physiology 309, no. 9 (November 2015): H1516-H1527.

PMID
26371162
Full Text

Wisler, JW, and Becker, RC. "Antithrombotic therapy: new areas to understand efficacy and bleeding." Expert Opinion on Therapeutic Targets 18, no. 12 (December 2014): 1427-1434. (Review)

PMID
25347453
Full Text

Wisler, JW, Xiao, K, Thomsen, ARB, and Lefkowitz, RJ. "Recent developments in biased agonism." Current Opinion in Cell Biology 27 (April 2014): 18-24. (Review)

PMID
24680426
Full Text

Wisler, J, Harris, E, Raisch, M, Mao, L, Kim, J, Rockman, H, and Lefkowitz, R. "NON-CANONICAL ANGIOTENSIN II TYPE 1A RECEPTOR-MEDIATED, BETA-ARRESTIN2-DEPENDENT SIGNALING CONTRIBUTES TO THORACIC AORTIC ANEURYSM FORMATION IN A MURINE MODEL OF MARFAN SYNDROME." April 2014.

Full Text

Wisler, JW, and Becker, RC. "Emerging paradigms in arterial thrombosis." Journal of Thrombosis and Thrombolysis 37, no. 1 (January 1, 2014): 4-11. (Review)

Full Text

Wisler, JW, and Becker, RC. "Emerging paradigms in arterial thrombosis." J Thromb Thrombolysis 37, no. 1 (January 2014): 4-11. (Review)

PMID
24046067
Full Text

Pages