James William Wisler, MD

Medical Instructor in the Department of Medicine
Campus mail 448 Jones Bldg, Durham, NC 27710
Phone (919) 684-4906
Email address jim.wisler@duke.edu

Education and Training

  • Cardiovascular Diseases Fellowship, Medicine, Duke University School of Medicine, 2011 - 2016
  • Internal Medicine Residency, Medicine, Duke University School of Medicine, 2009 - 2011
  • M.D., Ohio State University College of Medicine, 2009


Rein, Lindsay Am, James W. Wisler, Jihee Kim, Barbara Theriot, LiYin Huang, Trevor Price, Haeyoon Yang, et al. “β-Arrestin2 mediates progression of murine primary myelofibrosis..” Jci Insight 2, no. 24 (December 21, 2017). https://doi.org/10.1172/jci.insight.98094.

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Kahsai, Alem W., James W. Wisler, Jungmin Lee, Seungkirl Ahn, Thomas J. Cahill Iii, S Moses Dennison, Dean P. Staus, et al. “Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor..” Nat Chem Biol 12, no. 9 (September 2016): 709–16. https://doi.org/10.1038/nchembio.2126.

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Rein, Lindsay A. M., James W. Wisler, Barbara S. Theriot, Li-Yin Huang, Richard T. Premont, and Robert J. Lefkowitz. “beta-arrestin2 Is Necessary for Development of MPLW515L Mutant Primary Myelofibrosis.” In Blood, Vol. 126. AMER SOC HEMATOLOGY, 2015.


Wisler, James W., Emily M. Harris, Michael Raisch, Lan Mao, Jihee Kim, Howard A. Rockman, and Robert J. Lefkowitz. “The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome..” Am J Physiol Heart Circ Physiol 309, no. 9 (November 2015): H1516–27. https://doi.org/10.1152/ajpheart.00291.2015.

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Wisler, James, Emily Harris, Michael Raisch, Lan Mao, Jihee Kim, Howard Rockman, and Robert Lefkowitz. “NON-CANONICAL ANGIOTENSIN II TYPE 1A RECEPTOR-MEDIATED, BETA-ARRESTIN2-DEPENDENT SIGNALING CONTRIBUTES TO THORACIC AORTIC ANEURYSM FORMATION IN A MURINE MODEL OF MARFAN SYNDROME.” In Journal of the American College of Cardiology, 63:A2148–A2148. Elsevier BV, 2014. https://doi.org/10.1016/s0735-1097(14)62151-3.

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Han, Sang-oh, Kunhong Xiao, Jihee Kim, Jiao-Hui Wu, James W. Wisler, Nobuhiro Nakamura, Neil J. Freedman, and Sudha K. Shenoy. “MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors..” J Cell Biol 199, no. 5 (November 26, 2012): 817–30. https://doi.org/10.1083/jcb.201208192.

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