Jennifer Leigh Ingram, PhD

Assistant Professor in Medicine
Assistant Professor in Pathology
Assistant Professor in the Department of Surgery
Campus mail 201 Msrb1 Bldg, Durham, NC 27710
Phone (919) 668-1439
Email address jennifer.ingram@duke.edu

Dr. Ingram's research interests focus on the study of airway remodeling in human asthma. Proliferation, migration, and invasion of airway fibroblasts are key features of airway remodeling that contribute to diminished lung function over time. Dr. Ingram uses molecular biology approaches to define the effects of interleukin-13 (IL-13), a cytokine abundantly produced in the asthmatic airway, in the human airway fibroblast. She has identified important regulatory functions of several proteins prevalent in asthma that control fibroblast growth and pro-fibrotic growth factor production in response to IL-13. By understanding these pathways and their role in human asthma and the chronic effects of airway remodeling, novel treatment strategies may be developed.

Education and Training

  • Ph.D., North Carolina State University, 2000

Publications

Wang, Ying, Zhou Zhu, Tony D. Church, Njira L. Lugogo, Loretta G. Que, Dave Francisco, Jennifer L. Ingram, et al. “SHP-1 as a critical regulator of Mycoplasma pneumoniae-induced inflammation in human asthmatic airway epithelial cells.” J Immunol 188, no. 7 (April 1, 2012): 3371–81. https://doi.org/10.4049/jimmunol.1100573.

PMID
22371396
Full Text

Wang, Ying, Dennis R. Voelker, Njira L. Lugogo, Guirong Wang, Joanna Floros, Jennifer L. Ingram, Hong Wei Chu, et al. “Surfactant protein A is defective in abrogating inflammation in asthma.” Am J Physiol Lung Cell Mol Physiol 301, no. 4 (October 2011): L598–606. https://doi.org/10.1152/ajplung.00381.2010.

PMID
21784968
Full Text

Liang, Jiurong, Dianhua Jiang, Yoosun Jung, Ting Xie, Jennifer Ingram, Tony Church, Simone Degan, Maura Leonard, Monica Kraft, and Paul W. Noble. “Role of hyaluronan and hyaluronan-binding proteins in human asthma.” J Allergy Clin Immunol 128, no. 2 (August 2011): 403-411.e3. https://doi.org/10.1016/j.jaci.2011.04.006.

PMID
21570715
Full Text

Ingram, Jennifer L., Molly J. Huggins, Tony D. Church, Yuejuan Li, Dave C. Francisco, Simone Degan, Rafael Firszt, et al. “Airway fibroblasts in asthma manifest an invasive phenotype.” Am J Respir Crit Care Med 183, no. 12 (June 15, 2011): 1625–32. https://doi.org/10.1164/rccm.201009-1452OC.

PMID
21471104
Full Text

Firszt, R., T. D. Church, D. Francisco, D. Beaver, J. L. Ingram, and M. Kraft. “MMP-2 Inhibition Attenuates IL-13 Induced Collagen Type-1 mRNA Expression in Human Airway Fibroblasts in Asthma.” In Journal of Allergy and Clinical Immunology, 127:AB127–AB127. Elsevier BV, 2011. https://doi.org/10.1016/j.jaci.2010.12.509.

Full Text

Firszt, R., T. D. Church, D. Francisco, J. L. Ingram, and M. Kraft. “IL-13 Induces Procollagen 1 mRNA Expression in Human Airway Fibroblasts in Asthma.” In Journal of Allergy and Clinical Immunology, 125:AB106–AB106. Elsevier BV, 2010. https://doi.org/10.1016/j.jaci.2009.12.416.

Full Text

Firszt, R., T. D. Church, D. Francisco, C. Hathcock, D. Beaver, J. L. Ingram, and M. Kraft. “MMP Inhibition Attenuates IL-13 Induced Procollagen 1 MRNA Expression In Human Airway Fibroblasts In Asthma.” American Journal of Respiratory and Critical Care Medicine 181 (January 1, 2010).

Scholars@Duke

Ingram, J. L., M. J. Huggins, T. D. Church, D. Francisco, R. Firszt, S. Degan, P. W. Noble, D. Beaver, M. E. Sunday, and M. Kraft. “Interleukin-13 Induces Airway Fibroblast Invasion In Asthma: Implications For A Mechanism Dependent On MMPs And TGF-beta.” American Journal of Respiratory and Critical Care Medicine 181 (January 1, 2010).

Scholars@Duke

Pages