Jennifer Lynn Garst, MD

Professor of Medicine
Member of the Duke Cancer Institute
Campus mail 25176 Morris Bldg, Durham, NC 27710
Phone (919) 862-5400
Email address

1. Non-small cell and small cell lung cancer - intervention, epidemiology and treatment.
2. Clinical trials of combined modality therapy, cancer drug development, and new treatment approaches and supportive care for lung cancer.
3. Lung cancer as a women's health issue.
4. Supportive care for lung cancer patients including management of taste alteration, weight loss and declining performance status.
5. Clinical research in the Duke Oncology Outreach (DOORS) & DOC affiliate setting.
6. Standardization of management for common oncologic problems.

Clinical Research:

1. Principal Investigator:
TOP 96-02, "A Phase I/II Dose Escalation Study of Concurrent Navelbine and Radiation Inoperable Stage III"
TOP 96-03, "A Phase I/II Study of Weekly Docetaxel and Vinorelbine in Advanced and Relapsed Non-Small Cell Lung Carcinoma"
TOP 97-01, "A Phase I/II Study: Sequential Topotecan and Carboplatin/VP-16 for the Treatment of Small Cell Lung Cancer"
TOP 98-01, "A Phase I/II Study: Weekly CPT-11 with Vinorelbine in Advanced Non-Small Cell Lung Carcinoma"
TOP 98-02, "A Phase I/II Trial of Concurrent Carboplatin and Vinorelbine Chemotherapy with Radiation Followed by Surgery in Patients with Non-Small Cell Lung Carcinoma"
TOP 99-01, "A Feasibility Trial of Filgrastim-SD/01 to Support Carboplatin/ Navelbine (SD/01-CaN) Chemotherapy for the Treatment of Thoracic Malignancies"
TOP 00-03, "Phase II Trial of Gemcitabine and Oxaliplatin in the Treatment of Non-Small Cell Lung Cancer (NSCLC)"
TOP 00-01, "A Pilot Study of the Relative Velocity of Serum Tumor Marker CYFRA 21-1 as an Indicator of Early Chemotherapeutic Response in Advanced Non-Small Cell Lung Cancer"
"Evaluation of Oral Antiemetic Regimens for Moderately-High to Highly Emetogenic Chemotherapy: Pilot Study of Oral Ondansetron in Acute Chemotherapy Inducted Emesis (CIE) and a Randomized Double Blind Comparison of Ondansetron versus Dexamethasone versus Procholorperazine in Delayed CIE"
2. Co-Principal Investigator:
"A Phase I/II Study of Active Immunotherapy with Dexosomes Loaded with
Mage3.A2 and Mage4.A2 Peptides in HLA A2+ Patients with Metastatic
Non-Small Cell Lung Cancer Expressing Mage3 or Mage4 (AP Cells,
3D 97-01, "A Phase I Dose Escalation Research Study of Radiotherapy Using Three-Dimensional Treatment Planning Following Neoadjuvant Chemotherapy for Stage IIB/III Non-Small Cell Lung Cancer"
"Phase IV Pharmacokinetic Study in Chemonaive Patients with Stage IIIB or IV
Non-Small Cell Lung Cancer (NSCLC) Receiving Gemcitabine and
Cisplatin (Eli Lilly B9E-MC-JHQK)"
3. Initiation, organization and development of the Multidisciplinary Thoracic Oncology clinic
with clinical research at DVAMC, 1996
4. Development of four oncology clinical pathways at Duke University Medical Center, 1997
5. Implementation of 3 clinical research trials at DOORS Asheboro site, Randolph Hospital,

In Their Words

Education and Training

  • Fellow, Hematology, Oncology, Duke University School of Medicine, 1993 - 1996
  • Resident, Medicine, University of Texas Southwestern Medical Center, Medical School, 1991 - 1993
  • Intern, Medicine, University of Texas Southwestern Medical Center, Medical School, 1990 - 1991
  • M.D., Medical College of Georgia School of Medicine, 1990


Lynch, Thomas J., David R. Spigel, Julie Brahmer, Neal Fischbach, Jennifer Garst, Mohammad Jahanzeb, Priya Kumar, et al. “Safety and effectiveness of bevacizumab-containing treatment for non-small-cell lung cancer: final results of the ARIES observational cohort study.” J Thorac Oncol 9, no. 9 (September 2014): 1332–39.

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Bastian, Lori A., Laura J. Fish, Bercedis L. Peterson, Andrea K. Biddle, Jennifer Garst, Pauline Lyna, Stephanie Molner, et al. “Assessment of the impact of adjunctive proactive telephone counseling to promote smoking cessation among lung cancer patients' social networks.” Am J Health Promot 27, no. 3 (January 2013): 181–90.

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Porter, Laura S., Francis J. Keefe, Deborah Davis, Meredith Rumble, Cindy Scipio, and Jennifer Garst. “Attachment styles in patients with lung cancer and their spouses: associations with patient and spouse adjustment.” Support Care Cancer 20, no. 10 (October 2012): 2459–66.

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Govindan, Ramaswamy, Jeffrey Bogart, Thomas Stinchcombe, Xiaofei Wang, Lydia Hodgson, Robert Kratzke, Jennifer Garst, Timothy Brotherton, and Everett E. Vokes. “Randomized phase II study of pemetrexed, carboplatin, and thoracic radiation with or without cetuximab in patients with locally advanced unresectable non-small-cell lung cancer: Cancer and Leukemia Group B trial 30407.” J Clin Oncol 29, no. 23 (August 10, 2011): 3120–25.

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Bastian, Lori A., Laura J. Fish, Bercedis L. Peterson, Andrea K. Biddle, Jennifer Garst, Pauline Lyna, Stephanie Molner, et al. “Proactive recruitment of cancer patients' social networks into a smoking cessation trial.” Contemp Clin Trials 32, no. 4 (July 2011): 498–504.

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Porter, Laura S., Francis J. Keefe, Jennifer Garst, Donald H. Baucom, Colleen M. McBride, Daphne C. McKee, Linda Sutton, et al. “Caregiver-assisted coping skills training for lung cancer: results of a randomized clinical trial.” J Pain Symptom Manage 41, no. 1 (January 2011): 1–13.

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Ready, Neal, Pasi A. Jänne, Jeffrey Bogart, Thomas Dipetrillo, Jennifer Garst, Stephen Graziano, Lin Gu, et al. “Chemoradiotherapy and gefitinib in stage III non-small cell lung cancer with epidermal growth factor receptor and KRAS mutation analysis: cancer and leukemia group B (CALEB) 30106, a CALGB-stratified phase II trial.” J Thorac Oncol 5, no. 9 (September 2010): 1382–90.

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Ross, Helen J., George R. Blumenschein, Joseph Aisner, Nevena Damjanov, Afshin Dowlati, Jennifer Garst, James R. Rigas, et al. “Randomized phase II multicenter trial of two schedules of lapatinib as first- or second-line monotherapy in patients with advanced or metastatic non-small cell lung cancer.” Clin Cancer Res 16, no. 6 (March 15, 2010): 1938–49.

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Daniel, Marcella, Francis J. Keefe, Pauline Lyna, Bercedis Peterson, Jennifer Garst, Mike Kelley, Gerold Bepler, and Lori A. Bastian. “Persistent smoking after a diagnosis of lung cancer is associated with higher reported pain levels.” J Pain 10, no. 3 (March 2009): 323–28.

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Jones, Lee W., Neil D. Eves, Bercedis L. Peterson, Jennifer Garst, Jeffrey Crawford, Miranda J. West, Stephanie Mabe, David Harpole, William E. Kraus, and Pamela S. Douglas. “Safety and feasibility of aerobic training on cardiopulmonary function and quality of life in postsurgical nonsmall cell lung cancer patients: a pilot study.” Cancer 113, no. 12 (December 15, 2008): 3430–39.

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