Jennifer Lynn Garst, MD

Professor of Medicine
Member of the Duke Cancer Institute
Campus mail 25176 Morris Bldg, Durham, NC 27710
Phone (919) 862-5400
Email address garst001@mc.duke.edu

1. Non-small cell and small cell lung cancer - intervention, epidemiology and treatment.
2. Clinical trials of combined modality therapy, cancer drug development, and new treatment approaches and supportive care for lung cancer.
3. Lung cancer as a women's health issue.
4. Supportive care for lung cancer patients including management of taste alteration, weight loss and declining performance status.
5. Clinical research in the Duke Oncology Outreach (DOORS) & DOC affiliate setting.
6. Standardization of management for common oncologic problems.

Clinical Research:

1. Principal Investigator:
TOP 96-02, "A Phase I/II Dose Escalation Study of Concurrent Navelbine and Radiation Inoperable Stage III"
TOP 96-03, "A Phase I/II Study of Weekly Docetaxel and Vinorelbine in Advanced and Relapsed Non-Small Cell Lung Carcinoma"
TOP 97-01, "A Phase I/II Study: Sequential Topotecan and Carboplatin/VP-16 for the Treatment of Small Cell Lung Cancer"
TOP 98-01, "A Phase I/II Study: Weekly CPT-11 with Vinorelbine in Advanced Non-Small Cell Lung Carcinoma"
TOP 98-02, "A Phase I/II Trial of Concurrent Carboplatin and Vinorelbine Chemotherapy with Radiation Followed by Surgery in Patients with Non-Small Cell Lung Carcinoma"
TOP 99-01, "A Feasibility Trial of Filgrastim-SD/01 to Support Carboplatin/ Navelbine (SD/01-CaN) Chemotherapy for the Treatment of Thoracic Malignancies"
TOP 00-03, "Phase II Trial of Gemcitabine and Oxaliplatin in the Treatment of Non-Small Cell Lung Cancer (NSCLC)"
TOP 00-01, "A Pilot Study of the Relative Velocity of Serum Tumor Marker CYFRA 21-1 as an Indicator of Early Chemotherapeutic Response in Advanced Non-Small Cell Lung Cancer"
"Evaluation of Oral Antiemetic Regimens for Moderately-High to Highly Emetogenic Chemotherapy: Pilot Study of Oral Ondansetron in Acute Chemotherapy Inducted Emesis (CIE) and a Randomized Double Blind Comparison of Ondansetron versus Dexamethasone versus Procholorperazine in Delayed CIE"
2. Co-Principal Investigator:
"A Phase I/II Study of Active Immunotherapy with Dexosomes Loaded with
Mage3.A2 and Mage4.A2 Peptides in HLA A2+ Patients with Metastatic
Non-Small Cell Lung Cancer Expressing Mage3 or Mage4 (AP Cells,
Inc.)"
3D 97-01, "A Phase I Dose Escalation Research Study of Radiotherapy Using Three-Dimensional Treatment Planning Following Neoadjuvant Chemotherapy for Stage IIB/III Non-Small Cell Lung Cancer"
"Phase IV Pharmacokinetic Study in Chemonaive Patients with Stage IIIB or IV
Non-Small Cell Lung Cancer (NSCLC) Receiving Gemcitabine and
Cisplatin (Eli Lilly B9E-MC-JHQK)"
3. Initiation, organization and development of the Multidisciplinary Thoracic Oncology clinic
with clinical research at DVAMC, 1996
4. Development of four oncology clinical pathways at Duke University Medical Center, 1997
5. Implementation of 3 clinical research trials at DOORS Asheboro site, Randolph Hospital,
1997

In Their Words

Education and Training

  • M.D., Medical College of Georgia School of Medicine, 1990

Publications

Lynch, TJ, Spigel, DR, Brahmer, J, Fischbach, N, Garst, J, Jahanzeb, M, Kumar, P, Vidaver, RM, Wozniak, AJ, Fish, S, Flick, ED, Leon, L, Hazard, SJ, Kosty, MP, and ARIES Study Investigators, . "Safety and effectiveness of bevacizumab-containing treatment for non-small-cell lung cancer: final results of the ARIES observational cohort study." Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 9, no. 9 (September 2014): 1332-1339.

PMID
25122429
Full Text

Bastian, LA, Fish, LJ, Peterson, BL, Biddle, AK, Garst, J, Lyna, P, Molner, S, Bepler, G, Kelley, M, Keefe, FJ, and McBride, CM. "Assessment of the Impact of Adjunctive Proactive Telephone Counseling to Promote Smoking Cessation Among Lung Cancer Patients' Social Networks." AMERICAN JOURNAL OF HEALTH PROMOTION 27, no. 3 (2013): 181-190.

PMID
23286595
Full Text

Porter, LS, Keefe, FJ, Davis, D, Rumble, M, Scipio, C, and Garst, J. "Attachment styles in patients with lung cancer and their spouses: associations with patient and spouse adjustment." Support Care Cancer 20, no. 10 (October 2012): 2459-2466.

PMID
22246596
Full Text

Bastian, LA, Fish, LJ, Peterson, BL, Biddle, AK, Garst, J, Lyna, P, Molner, S, Bepler, G, Kelley, M, Keefe, FJ, and McBride, CM. "Proactive recruitment of cancer patients' social networks into a smoking cessation trial." Contemp Clin Trials 32, no. 4 (July 2011): 498-504.

PMID
21382509
Full Text

Porter, LS, Keefe, FJ, Garst, J, Baucom, DH, McBride, CM, McKee, DC, Sutton, L, Carson, K, Knowles, V, Rumble, M, and Scipio, C. "Caregiver-assisted coping skills training for lung cancer: results of a randomized clinical trial." J Pain Symptom Manage 41, no. 1 (January 2011): 1-13.

PMID
20832982
Full Text

Govindan, R, Bogart, J, Stinchcombe, T, Wang, X, Hodgson, L, Kratzke, R, Garst, J, Brotherton, T, and Vokes, EE. "Randomized phase II study of pemetrexed, carboplatin, and thoracic radiation with or without cetuximab in patients with locally advanced unresectable non-small-cell lung cancer: Cancer and leukemia group B trial 30407." Journal of Clinical Oncology 29, no. 23 (2011): 3120-3125.

PMID
21747084
Full Text

Ready, N, Jänne, PA, Bogart, J, Dipetrillo, T, Garst, J, Graziano, S, Gu, L, Wang, X, Green, MR, and Vokes, EE. "Chemoradiotherapy and gefitinib in stage III non-small cell lung cancer with epidermal growth factor receptor and KRAS mutation analysis: Cancer and Leukemia Group B (CALEB) 30106, a CALGB-Stratified Phase II Trial." Journal of Thoracic Oncology 5, no. 9 (2010): 1382-1390.

PMID
20686428
Full Text

Ross, HJ, Jr, GRB, Aisner, J, Damjanov, N, Dowlati, A, Garst, J, Rigas, JR, Smylie, M, Hassani, H, Allen, KE, Leopold, L, Zaks, TZ, and Shepherd, FA. "Randomized phase II multicenter trial of two schedules of lapatinib as first- or second-line monotherapy in patients with advanced or metastatic non-small cell lung cancer." Clinical Cancer Research 16, no. 6 (2010): 1938-1949.

PMID
20215545
Full Text

Daniel, M, Keefe, FJ, Lyna, P, Peterson, B, Garst, J, Kelley, M, Bepler, G, and Bastian, LA. "Persistent smoking after a diagnosis of lung cancer is associated with higher reported pain levels." J Pain 10, no. 3 (March 2009): 323-328.

PMID
19254679
Full Text

Jones, LW, Eves, ND, Peterson, BL, Garst, J, Crawford, J, West, MJ, Mabe, S, Harpole, D, Kraus, WE, and Douglas, PS. "Safety and feasibility of aerobic training on cardiopulmonary function and quality of life in postsurgical nonsmall cell lung cancer patients: a pilot study." Cancer 113, no. 12 (December 15, 2008): 3430-3439.

PMID
18988290
Full Text

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