Joe Brice Weinberg, MD

Professor of Medicine
Associate Professor of Obstetrics and Gynecology
Professor of Immunology
Affiliate, Duke Global Health Institute
Member of the Duke Cancer Institute
Campus mail Duke Box 3396, Durham, NC 27708
Phone (919) 286-6833
Email address weinb001@duke.edu

Dr. Weinberg is a board-certified hematologist and medical oncologist who serves as Professor of Medicine and Immunology and Associate Professor of Obstetrics and Gynecology at the Duke University Medical Center, and staff physician in hematology-oncology at the Durham V.A. Medical Center. His clinical interests are in hematology and oncology, and his research focuses on blood cells, nitric oxide (NO), and leukemia. The work includes studies of resistance to infection, pathways of inflammation, and regulation of normal and leukemic cell life and death. His current work includes studies of leukemia (primarily chronic lymphocytic leukemia); the roles of NO and arginine in the resistance to malaria; and the interactions of NO, prostaglandins, and mechanical force in inflammation and arthritis.

Education and Training

  • Fellowship, Hematology Oncology, University of Utah School of Medicine, 1973 - 1976
  • Internship & Residency, University of Arkansas at Little Rock, 1969 - 1971
  • M.D., University of Arkansas at Little Rock, 1969
  • B.S., University of Arkansas, Fayetteville, 1966

Publications

Heyman, B., A. D. Volkheimer, and J. B. Weinberg. “Double IGHV DNA gene rearrangements in CLL: influence of mixed-mutated and -unmutated rearrangements on outcomes in CLL..” Blood Cancer J 6, no. 7 (July 1, 2016). https://doi.org/10.1038/bcj.2016.49.

PMID
27367477
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Friedman, Daphne R., Alexander B. Sibley, Kouros Owzar, Kari G. Chaffee, Susan Slager, Neil E. Kay, Curtis A. Hanson, et al. “Relationship of blood monocytes with chronic lymphocytic leukemia aggressiveness and outcomes: a multi-institutional study..” Am J Hematol 91, no. 7 (July 2016): 687–91. https://doi.org/10.1002/ajh.24376.

PMID
27037726
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Dennis, Paul A., J Brice Weinberg, Patrick S. Calhoun, Lana L. Watkins, Andrew Sherwood, Michelle F. Dennis, and Jean C. Beckham. “An investigation of vago-regulatory and health-behavior accounts for increased inflammation in posttraumatic stress disorder..” J Psychosom Res 83 (April 2016): 33–39. https://doi.org/10.1016/j.jpsychores.2016.02.008.

PMID
27020074
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Berndt, Sonja I., Nicola J. Camp, Christine F. Skibola, Joseph Vijai, Zhaoming Wang, Jian Gu, Alexandra Nieters, et al. “Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia..” Nat Commun 7 (March 9, 2016). https://doi.org/10.1038/ncomms10933.

PMID
26956414
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Rubach, Matthew P., Salvatore Florence, Haoyue Zhang, Nicholas M. Anstey, Tsin W. Yeo, David S. Millington, J Brice Weinberg, Esther D. Mwaikambo, and Donald L. Granger. “INCREASED TOTAL BODY ARGININE FLUX AND DECREASED NITRIC OXIDE SYNTHESIS IN SEVERE FALCIPARUM MALARIA.” In American Journal of Tropical Medicine and Hygiene, 93:189–189. AMER SOC TROP MED & HYGIENE, 2015.

Scholars@Duke

Vakkalanka, Swaroop, Kumar V. Penmetsa, Dawn Chasse, Youwei Chen, Srikant Viswanadha, Daphne R. Friedman, and J Brice Weinberg. “Abstract A24: The dual PI3K δ/γ inhibitor, RP6530, in combination with ibrutinib or fludarabine, synergistically enhances cytotoxicity in primary CLL cells in vitro..” In Drug Discovery. American Association for Cancer Research, 2015. https://doi.org/10.1158/1557-3265.hemmal14-a24.

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Brander, Danielle, Dale Christensen, Alicia Volkheimer, TIffany Stewart, Youwei Chen, Daphne Friedman, and J Brice Weinberg. “Set alpha/beta-mrna isoform ratio by a novel qpcr assay has prognostic significance in chronic lymphocytic leukemia and may be modulated by treatment.” Leukemia & Lymphoma 56 (September 1, 2015): 121–22.

Scholars@Duke

Friedman, Daphne Ruth, Tiffany Stewart, Eross Guadalupe, Danielle M. Brander, David S. Pisetsky, and J Brice Weinberg. “Pan-caspase peptide inhibitor to induce primary chronic lymphocytic leukemia (CLL) cell death through a non-apoptotic and non-necroptotic mechanism..” In Journal of Clinical Oncology, 33:e13536–e13536. American Society of Clinical Oncology (ASCO), 2015. https://doi.org/10.1200/jco.2015.33.15_suppl.e13536.

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Yeo, Tsin W., Daniel A. Lampah, Enny Kenangalem, Emiliana Tjitra, Ric N. Price, J Brice Weinberg, Keith Hyland, Donald L. Granger, and Nicholas M. Anstey. “Impaired systemic tetrahydrobiopterin bioavailability and increased dihydrobiopterin in adult falciparum malaria: association with disease severity, impaired microvascular function and increased endothelial activation..” Plos Pathog 11, no. 3 (March 2015). https://doi.org/10.1371/journal.ppat.1004667.

PMID
25764397
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Rubach, Matthew P., Jackson Mukemba, Salvatore Florence, Bert K. Lopansri, Keith Hyland, Alicia D. Volkheimer, Tsin W. Yeo, et al. “Impaired systemic tetrahydrobiopterin bioavailability and increased oxidized biopterins in pediatric falciparum malaria: association with disease severity..” Plos Pathog 11, no. 3 (March 2015). https://doi.org/10.1371/journal.ppat.1004655.

PMID
25764173
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