John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Chiarito, M, Cao, D, Cannata, F, Godino, C, Lodigiani, C, Ferrante, G, Lopes, RD, Alexander, JH, Reimers, B, Condorelli, G, and Stefanini, GG. "Direct Oral Anticoagulants in Addition to Antiplatelet Therapy for Secondary Prevention After Acute Coronary Syndromes: A Systematic Review and Meta-analysis." Jama Cardiology 3, no. 3 (March 2018): 234-241.

PMID
29417147
Full Text

Lopes, RD, Rordorf, R, De Ferrari, GM, Leonardi, S, Thomas, L, Wojdyla, DM, Ridefelt, P, Lawrence, JH, De Caterina, R, Vinereanu, D, Hanna, M, Flaker, G, Al-Khatib, SM, Hohnloser, SH, Alexander, JH, Granger, CB, Wallentin, L, and ARISTOTLE Committees and Investigators, . "Digoxin and Mortality in Patients With Atrial Fibrillation." Journal of the American College of Cardiology 71, no. 10 (March 2018): 1063-1074.

PMID
29519345
Full Text

Rao, MP, Vinereanu, D, Wojdyla, DM, Alexander, JH, Atar, D, Hylek, EM, Hanna, M, Wallentin, L, Lopes, RD, Gersh, BJ, Granger, CB, and Apixaban for Reduction in Stroke Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Investigators, . "Clinical Outcomes and History of Fall in Patients with Atrial Fibrillation Treated with Oral Anticoagulation: Insights From the ARISTOTLE Trial." The American Journal of Medicine 131, no. 3 (March 2018): 269-275.e2.

PMID
29122636
Full Text

Sherwood, MW, Lopes, RD, Sun, JL, Liaw, D, Harrington, RA, Wallentin, L, Laskowitz, DT, James, SK, Goodman, SG, Darius, H, Lewis, BS, Gibson, CM, Pieper, KS, and Alexander, JH. "Apixaban following acute coronary syndromes in patients with prior stroke: Insights from the APPRAISE-2 trial." American Heart Journal 197 (March 2018): 1-8.

PMID
29447769
Full Text

Kopin, D, Jones, WS, Sherwood, MW, Wojdyla, DM, Wallentin, L, Lewis, BS, Verheugt, FWA, Vinereanu, D, Bahit, MC, Halvorsen, S, Huber, K, Parkhomenko, A, Granger, CB, Lopes, RD, and Alexander, JH. "Percutaneous coronary intervention and antiplatelet therapy in patients with atrial fibrillation receiving apixaban or warfarin: Insights from the ARISTOTLE trial." American Heart Journal 197 (March 2018): 133-141.

PMID
29447773
Full Text

Hijazi, Z, Oldgren, J, Lindbäck, J, Alexander, JH, Connolly, SJ, Eikelboom, JW, Ezekowitz, MD, Held, C, Hylek, EM, Lopes, RD, Yusuf, S, Granger, CB, Siegbahn, A, Wallentin, L, and ARISTOTLE and RE-LY Investigators, . "A biomarker-based risk score to predict death in patients with atrial fibrillation: the ABC (age, biomarkers, clinical history) death risk score." European Heart Journal 39, no. 6 (February 2018): 477-485.

PMID
29069359
Full Text

Browndyke, JN, Berger, M, Smith, PJ, Harshbarger, TB, Monge, ZA, Panchal, V, Bisanar, TL, Glower, DD, Alexander, JH, Cabeza, R, Welsh-Bohmer, K, Newman, MF, Mathew, JP, and Duke Neurologic Outcomes Research Group (NORG), . "Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults." Human Brain Mapping 39, no. 2 (February 2018): 985-1003.

PMID
29164774
Full Text

Pol, T, Held, C, Westerbergh, J, Lindbäck, J, Alexander, JH, Alings, M, Erol, C, Goto, S, Halvorsen, S, Huber, K, Hanna, M, Lopes, RD, Ruzyllo, W, Granger, CB, and Hijazi, Z. "Dyslipidemia and Risk of Cardiovascular Events in Patients With Atrial Fibrillation Treated With Oral Anticoagulation Therapy: Insights From the ARISTOTLE (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation) Trial." Journal of the American Heart Association 7, no. 3 (February 2018).

PMID
29419390
Full Text

Alexander, JH, Corrigan-Curay, J, and McClellan, M. "The Clinical Trials Transformation Initiative: Looking back, looking forward." Clinical trials (London, England) 15, no. 1_suppl (February 2018): 3-4.

PMID
29452518
Full Text

Sandhu, RK, Ezekowitz, JA, Hijazi, Z, Westerbergh, J, Aulin, J, Alexander, JH, Granger, CB, Halvorsen, S, Hanna, MS, Lopes, RD, Siegbahn, A, and Wallentin, L. "Obesity paradox on outcome in atrial fibrillation maintained even considering the prognostic influence of biomarkers: insights from the ARISTOTLE trial." Open Heart 5, no. 2 (January 2018): e000908-null.

PMID
30487982
Full Text

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