John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 200 Morris Street, Durham, NC 27701
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Wiggins, NB, Granger, CB, and Alexander, JH. "Novel oral anticoagulants after acute coronary syndromes." Cardiovasc Drugs Ther 26, no. 3 (June 2012): 265-271. (Review)

PMID
22434545
Full Text

Easton, JD, Lopes, RD, Bahit, MC, Wojdyla, DM, Granger, CB, Wallentin, L, Alings, M, Goto, S, Lewis, BS, Rosenqvist, M, Hanna, M, Mohan, P, Alexander, JH, Diener, H-C, and ARISTOTLE Committees and Investigators, . "Apixaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of the ARISTOTLE trial." The Lancet. Neurology 11, no. 6 (June 2012): 503-511.

PMID
22572202
Full Text

Vavalle, JP, and Alexander, JH. "Authors' reply to "the not so 'ideal' body weight-based dosing of Integrilin in obesity"." American Heart Journal 163, no. 4 (April 1, 2012). (Letter)

Full Text

Lopes, RD, Mehta, RH, Hafley, GE, Williams, JB, Mack, MJ, Peterson, ED, Allen, KB, Harrington, RA, Gibson, CM, Califf, RM, Kouchoukos, NT, Ferguson, TB, Alexander, JH, and Project of Ex Vivo Vein Graft Engineering via Transfection IV (PREVENT IV) Investigators, . "Relationship between vein graft failure and subsequent clinical outcomes after coronary artery bypass surgery." Circulation 125, no. 6 (February 2012): 749-756.

PMID
22238227
Full Text

Al-Khatib, SM, Alexander, JH, Lopes, RD, Mahaffey, KW, Patel, MR, and Granger, CB. "Promise of factor Xa inhibition in atrial fibrillation." Curr Cardiol Rep 14, no. 1 (February 2012): 70-78. (Review)

PMID
22109539
Full Text

Mehta, RH, Stebbins, AS, Lopes, RD, Califf, RM, Pieper, KS, Armstrong, PW, Van de Werf, F, Hochman, JS, White, HD, Topol, EJ, Alexander, JH, and Granger, CB. "Comparison of incidence of bleeding and mortality of men versus women with ST-elevation myocardial infarction treated with fibrinolysis." The American Journal of Cardiology 109, no. 3 (February 2012): 320-326.

PMID
22078221
Full Text

Smith, PK, Michler, RE, Woo, YJ, Alexander, JH, Puskas, JD, Parides, MK, Hahn, RT, Williams, JB, Dent, JM, Ferguson, TB, Moquete, E, Rose, EA, Pagé, P, Jeffries, NO, O'Gara, PT, and Ascheim, DD. "Design, rationale, and initiation of the Surgical Interventions for Moderate Ischemic Mitral Regurgitation Trial: a report from the Cardiothoracic Surgical Trials Network." The Journal of thoracic and cardiovascular surgery 143, no. 1 (January 2012): 111-117.e1.

PMID
21788032
Full Text

Koshizaka, M, Green, JB, and Alexander, JH. "Glycemic management in diabetes and the associated cardiovascular risk: are we helping or hurting our patients?." Circ J 76, no. 7 (2012): 1572-1580. (Review)

PMID
22789974
Scholars@Duke

Herrmann, HC, Gertz, ZM, Silvestry, FE, Wiegers, SE, Woo, YJ, Hermiller, J, Segar, D, Heimansohn, D, Gray, W, Homma, S, Argenziano, M, Wang, A, Jollis, J, Lampert, MB, Alexander, J, Mauri, L, Foster, E, Glower, D, and Feldman, T. "Effects of atrial fibrillation on treatment of mitral regurgitation in the EVEREST II (Endovascular valve edge-to-edge repair study) randomized trial." Journal of the American College of Cardiology 59, no. 14 (2012): 1312-1319.

PMID
22464260
Full Text

Vavalle, JP, Stevens, SR, Hassinger, N, Cohen, MG, Arnold, A, Kandzari, DE, Aguirre, FV, Gretler, DD, and Alexander, JH. "The kinetics of integrilin limited by obesity: a multicenter randomized pharmacokinetic and pharmacodynamic clinical trial." American Heart Journal 162, no. 6 (December 2011): 996-1002.

PMID
22137072
Full Text

Pages