John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 200 Morris Street, Durham, NC 27701
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital, Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Houman Fekrazad, M., Renato D. Lopes, Gregg J. Stashenko, John H. Alexander, and David Garcia. “Treatment of venous thromboembolism: guidelines translated for the clinician..” J Thromb Thrombolysis 28, no. 3 (October 2009): 270–75. https://doi.org/10.1007/s11239-009-0374-7.

PMID
19579012
Full Text

Katz, Jason N., Amanda L. Stebbins, John H. Alexander, Harmony R. Reynolds, Karen S. Pieper, Witold Ruzyllo, Karl Werdan, et al. “Predictors of 30-day mortality in patients with refractory cardiogenic shock following acute myocardial infarction despite a patent infarct artery..” Am Heart J 158, no. 4 (October 2009): 680–87. https://doi.org/10.1016/j.ahj.2009.08.005.

PMID
19781431
Full Text

Lopes, Renato D., Gail E. Hafley, Keith B. Allen, T Bruce Ferguson, Eric D. Peterson, Robert A. Harrington, Rajendra H. Mehta, et al. “Endoscopic versus open vein-graft harvesting in coronary-artery bypass surgery..” N Engl J Med 361, no. 3 (July 16, 2009): 235–44. https://doi.org/10.1056/NEJMoa0900708.

PMID
19605828
Full Text

Kraai, Erik P., Renato D. Lopes, John H. Alexander, and David Garcia. “Perioperative management of anticoagulation: guidelines translated for the clinician..” J Thromb Thrombolysis 28, no. 1 (July 2009): 16–22. https://doi.org/10.1007/s11239-009-0313-7.

PMID
19242654
Full Text

APPRAISE Steering Committee and Investigators, Lars, John H. Alexander, Richard C. Becker, Deepak L. Bhatt, Frank Cools, Filippo Crea, Mikael Dellborg, et al. “Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial..” Circulation 119, no. 22 (June 9, 2009): 2877–85. https://doi.org/10.1161/CIRCULATIONAHA.108.832139.

PMID
19470889
Full Text

Turer, Aslan T., Kenneth W. Mahaffey, Emily Honeycutt, Robert H. Tuttle, Linda K. Shaw, Michael H. Sketch, Peter K. Smith, Robert M. Califf, and John H. Alexander. “Influence of body mass index on the efficacy of revascularization in patients with coronary artery disease..” J Thorac Cardiovasc Surg 137, no. 6 (June 2009): 1468–74. https://doi.org/10.1016/j.jtcvs.2008.11.047.

PMID
19464466
Full Text

Bhatt, Deepak L., Kandice Kottke-Marchant, John H. Alexander, W Frank Peacock, and Marc S. Sabatine. “Platelet response in practice: Applying new insights and tools for testing and treatment..” Cleve Clin J Med 76 Suppl 1 (April 2009): S24–32. https://doi.org/10.3949/ccjm.76.s1.04.

PMID
19332591
Full Text

Alexander, John H. “The current state of antiplatelet therapy in acute coronary syndromes: the data and the real world..” Cleve Clin J Med 76 Suppl 1 (April 2009): S16–23. https://doi.org/10.3949/ccjm.76.s1.03.

PMID
19332589
Full Text

Lopes, Renato D., Jonathan P. Piccini, Elaine M. Hylek, Christopher B. Granger, and John H. Alexander. “Antithrombotic therapy in atrial fibrillation: guidelines translated for the clinician..” J Thromb Thrombolysis 26, no. 3 (December 2008): 167–74. https://doi.org/10.1007/s11239-008-0272-4.

PMID
18807225
Full Text

Mehta, Rajendra H., Gail E. Hafley, C Michael Gibson, Robert A. Harrington, Eric D. Peterson, Michael J. Mack, Nicholas T. Kouchoukos, et al. “Influence of preoperative renal dysfunction on one-year bypass graft patency and two-year outcomes in patients undergoing coronary artery bypass surgery..” J Thorac Cardiovasc Surg 136, no. 5 (November 2008): 1149–55. https://doi.org/10.1016/j.jtcvs.2008.02.085.

PMID
19026795
Full Text

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