John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

APPRAISE Steering Committee and Investigators, , Alexander, JH, Becker, RC, Bhatt, DL, Cools, F, Crea, F, Dellborg, M, Fox, KAA, Goodman, SG, Harrington, RA, Huber, K, Husted, S, Lewis, BS, Lopez-Sendon, J, Mohan, P, Montalescot, G, Ruda, M, Ruzyllo, W, Verheugt, F, and Wallentin, L. "Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial." Circulation 119, no. 22 (June 2009): 2877-2885.

PMID
19470889
Full Text

Katz, JN, Stebbins, AL, Alexander, JH, Reynolds, HR, Pieper, KS, Ruzyllo, W, Werdan, K, Geppert, A, Dzavik, V, Werf, FVD, and Hochman, JS. "Predictors of 30-day mortality in patients with refractory cardiogenic shock following acute myocardial infarction despite a patent infarct artery." American Heart Journal 158, no. 4 (2009): 680-687.

PMID
19781431
Full Text

Bhatt, DL, Kottke-Marchant, K, Alexander, JH, Peacock, WF, and Sabatine, MS. "Platelet response in practice: Applying new insights and tools for testing and treatment." Cleveland Clinic Journal of Medicine 76, no. SUPPL.1 (2009): S24-S32.

PMID
19332591
Full Text

Alexander, JH. "The current state of antiplatelet therapy in acute coronary syndromes: The data and the real world." Cleveland Clinic Journal of Medicine 76, no. SUPPL.1 (2009): S16-S23.

PMID
19332589
Full Text

Lopes, RD, Piccini, JP, Hylek, EM, Granger, CB, and Alexander, JH. "Antithrombotic therapy in atrial fibrillation: guidelines translated for the clinician." J Thromb Thrombolysis 26, no. 3 (December 2008): 167-174. (Review)

PMID
18807225
Full Text

Mehta, RH, Hafley, GE, Gibson, CM, Harrington, RA, Peterson, ED, Mack, MJ, Kouchoukos, NT, Califf, RM, Ferguson, TB, Alexander, JH, and Project of Ex-vivo Vein Graft Engineering via Transfection (PREVENT)-IV Investigators, . "Influence of preoperative renal dysfunction on one-year bypass graft patency and two-year outcomes in patients undergoing coronary artery bypass surgery." The Journal of Thoracic and Cardiovascular Surgery 136, no. 5 (November 2008): 1149-1155.

PMID
19026795
Full Text

Alexander, JH, Ellis, SJ, and Tardif, JC. "In reply." Jama Journal of the American Medical Association 300, no. 9 (September 3, 2008): 1021-1022. (Letter)

Full Text

Yau, JM, Alexander, JH, Hafley, G, Mahaffey, KW, Mack, MJ, Kouchoukos, N, Goyal, A, Peterson, ED, Gibson, CM, Califf, RM, Harrington, RA, Ferguson, TB, and PREVENT IV Investigators, . "Impact of perioperative myocardial infarction on angiographic and clinical outcomes following coronary artery bypass grafting (from PRoject of Ex-vivo Vein graft ENgineering via Transfection [PREVENT] IV)." The American Journal of Cardiology 102, no. 5 (September 2008): 546-551.

PMID
18721510
Full Text

Chan, MY, Cohen, MG, Dyke, CK, Myles, SK, Aberle, LG, Lin, M, Walder, J, Steinhubl, SR, Gilchrist, IC, Kleiman, NS, Vorchheimer, DA, Chronos, N, Melloni, C, Alexander, JH, Harrington, RA, Tonkens, RM, Becker, RC, and Rusconi, CP. "Phase 1b randomized study of antidote-controlled modulation of factor IXa activity in patients with stable coronary artery disease." Circulation 117, no. 22 (June 2008): 2865-2874.

PMID
18506005
Full Text

Chan, MY, Rusconi, CP, Alexander, JH, Tonkens, RM, Harrington, RA, and Becker, RC. "A randomized, repeat-dose, pharmacodynamic and safety study of an antidote-controlled factor IXa inhibitor." J Thromb Haemost 6, no. 5 (May 2008): 789-796.

PMID
18284597
Full Text

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