John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Jaspers Focks, J, Brouwer, MA, Wojdyla, DM, Thomas, L, Lopes, RD, Washam, JB, Lanas, F, Xavier, D, Husted, S, Wallentin, L, Alexander, JH, Granger, CB, and Verheugt, FWA. "Polypharmacy and effects of apixaban versus warfarin in patients with atrial fibrillation: post hoc analysis of the ARISTOTLE trial." BMJ (Clinical research ed.) 353 (June 15, 2016): i2868-.

PMID
27306620
Full Text

Hijazi, Z, Oldgren, J, Lindbäck, J, Alexander, JH, Connolly, SJ, Eikelboom, JW, Ezekowitz, MD, Held, C, Hylek, EM, Lopes, RD, Siegbahn, A, Yusuf, S, Granger, CB, Wallentin, L, and ARISTOTLE and RE-LY Investigators, . "The novel biomarker-based ABC (age, biomarkers, clinical history)-bleeding risk score for patients with atrial fibrillation: a derivation and validation study." Lancet (London, England) 387, no. 10035 (June 2016): 2302-2311.

PMID
27056738
Full Text

Harskamp, RE, Alexander, JH, Ferguson, TB, Hager, R, Mack, MJ, Englum, B, Wojdyla, D, Schulte, PJ, Kouchoukos, NT, de Winter, RJ, Gibson, CM, Peterson, ED, Harrington, RA, Smith, PK, and Lopes, RD. "Response to Letters Regarding Article, "Frequency and Predictors of Internal Mammary Artery Graft Failure and Subsequent Clinical Outcomes: Insights From the Project of Ex-Vivo Vein Graft Engineering via Transfection (PREVENT) IV Trial"." Circulation 133, no. 21 (May 2016): e665-. (Letter)

PMID
27217439
Full Text

Alexander, JH, and Thomas, LE. "Using Data to Guide Anticoagulation in Patients With Atrial Fibrillation: Does the Analysis Fit the Question?." JAMA cardiology 1, no. 2 (May 2016): 121-122.

PMID
27437881
Full Text

Ganson, NJ, Povsic, TJ, Sullenger, BA, Alexander, JH, Zelenkofske, SL, Sailstad, JM, Rusconi, CP, and Hershfield, MS. "Pre-existing anti-polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer." The Journal of allergy and clinical immunology 137, no. 5 (May 2016): 1610-1613.e7.

PMID
26688515
Full Text

Hijazi, Z, Lindbäck, J, Alexander, JH, Hanna, M, Held, C, Hylek, EM, Lopes, RD, Oldgren, J, Siegbahn, A, Stewart, RAH, White, HD, Granger, CB, Wallentin, L, and ARISTOTLE and STABILITY Investigators, . "The ABC (age, biomarkers, clinical history) stroke risk score: a biomarker-based risk score for predicting stroke in atrial fibrillation." European heart journal 37, no. 20 (May 2016): 1582-1590.

PMID
26920728
Full Text

De Caterina, R, Andersson, U, Alexander, JH, Al-Khatib, SM, Bahit, MC, Goto, S, Hanna, M, Held, C, Hohnloser, S, Hylek, EM, Lanas, F, Lopes, RD, López-Sendón, J, Renda, G, Horowitz, J, Granger, CB, Wallentin, L, and ARISTOTLE Investigators, . "History of bleeding and outcomes with apixaban versus warfarin in patients with atrial fibrillation in the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial." American heart journal 175 (May 2016): 175-183.

PMID
27179738
Full Text

Alexander, JH, and Smith, PK. "Coronary-Artery Bypass Grafting." The New England journal of medicine 374, no. 20 (May 2016): 1954-1964. (Review)

PMID
27192673
Full Text

Lincoff, AM, Alexander, JH, and Mehran, R. "REGULATE-PCI trial--Author's reply." Lancet (London, England) 387, no. 10027 (April 7, 2016): 1510-1511. (Letter)

PMID
27115975
Full Text

Kragholm, K, Goldstein, SA, Yang, Q, Lopes, RD, Schulte, PJ, Bernacki, GM, White, HD, Mahaffey, KW, Giugliano, RP, Armstrong, PW, Harrington, RA, Tricoci, P, Van de Werf, F, Alexander, JH, Alexander, KP, and Newby, LK. "Trends in Enrollment, Clinical Characteristics, Treatment, and Outcomes According to Age in Non-ST-Segment-Elevation Acute Coronary Syndromes Clinical Trials." Circulation 133, no. 16 (April 2016): 1560-1573.

PMID
26957532
Full Text

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