John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Michael Gibson, C, Korjian, S, Tricoci, P, Daaboul, Y, Yee, M, Jain, P, Alexander, JH, Steg, PG, Lincoff, AM, Kastelein, JJP, Mehran, R, D'Andrea, DM, Deckelbaum, LI, Merkely, B, Zarebinski, M, Ophuis, TO, and Harrington, RA. "Safety and Tolerability of CSL112, a Reconstituted, Infusible, Plasma-Derived Apolipoprotein A-I, After Acute Myocardial Infarction: The AEGIS-I Trial (ApoA-I Event Reducing in Ischemic Syndromes I)." Circulation 134, no. 24 (December 2016): 1918-1930.

PMID
27881559
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Domanski, M, Farkouh, ME, Zak, V, French, J, Alexander, JH, Bochenek, A, Hamon, M, Mahaffey, K, Puskas, J, Smith, P, Shrader, P, and Fuster, V. "Relation of Post-Coronary Artery Bypass Graft Creatine Kinase-MB Elevations and New Q Waves With Long-Term Cardiovascular Death in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease." The American journal of cardiology 118, no. 11 (December 2016): 1655-1660.

PMID
27816118
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Oldgren, J, Hijazi, Z, Lindbäck, J, Alexander, JH, Connolly, SJ, Eikelboom, JW, Ezekowitz, MD, Granger, CB, Hylek, EM, Lopes, RD, Siegbahn, A, Yusuf, S, Wallentin, L, and RE-LY and ARISTOTLE Investigators, . "Performance and Validation of a Novel Biomarker-Based Stroke Risk Score for Atrial Fibrillation." Circulation 134, no. 22 (November 2016): 1697-1707.

PMID
27569438
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Sandhu, RK, Ezekowitz, J, Andersson, U, Alexander, JH, Granger, CB, Halvorsen, S, Hanna, M, Hijazi, Z, Jansky, P, Lopes, RD, and Wallentin, L. "The 'obesity paradox' in atrial fibrillation: observations from the ARISTOTLE (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation) trial." European Heart Journal 37, no. 38 (October 2016): 2869-2878.

PMID
27071819
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Gibson, CM, Korjian, S, Tricoci, P, Daaboul, Y, Alexander, JH, Steg, PG, Lincoff, AM, Kastelein, JJP, Mehran, R, D'Andrea, D, Merkely, B, Zarebinski, M, Ophius, TO, and Harrington, RA. "Rationale and design of Apo-I Event Reduction in Ischemic Syndromes I (AEGIS-I): A phase 2b, randomized, placebo-controlled, dose-ranging trial to investigate the safety and tolerability of CSL112, a reconstituted, infusible, human apoA-I, after acute myocardial infarction." American heart journal 180 (October 2016): 22-28.

PMID
27659879
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Capoulade, R, Zeng, X, Overbey, JR, Ailawadi, G, Alexander, JH, Ascheim, D, Bowdish, M, Gelijns, AC, Grayburn, P, Kron, IL, Levine, RA, Mack, MJ, Melnitchouk, S, Michler, RE, Mullen, JC, O'Gara, P, Parides, MK, Smith, P, Voisine, P, Hung, J, and Cardiothoracic Surgical Trials Network (CTSN) Investigators, . "Impact of Left Ventricular to Mitral Valve Ring Mismatch on Recurrent Ischemic Mitral Regurgitation After Ring Annuloplasty." Circulation 134, no. 17 (October 2016): 1247-1256.

PMID
27777294
Full Text

Alexander, JH, Andersson, U, Lopes, RD, Hijazi, Z, Hohnloser, SH, Ezekowitz, JA, Halvorsen, S, Hanna, M, Commerford, P, Ruzyllo, W, Huber, K, Al-Khatib, SM, Granger, CB, Wallentin, L, and Apixaban for Reduction of Stroke and Other Thromboembolic Complications in Atrial Fibrillation (ARISTOTLE) Investigators, . "Apixaban 5 mg Twice Daily and Clinical Outcomes in Patients With Atrial Fibrillation and Advanced Age, Low Body Weight, or High Creatinine: A Secondary Analysis of a Randomized Clinical Trial." JAMA cardiology 1, no. 6 (September 2016): 673-681.

PMID
27463942
Full Text

Alexander, JH, and Smith, PK. "Coronary-Artery Bypass Grafting." The New England journal of medicine 375, no. 10 (September 2016): e22-. (Letter)

PMID
27602683
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Hijazi, Z, Hohnloser, SH, Andersson, U, Alexander, JH, Hanna, M, Keltai, M, Parkhomenko, A, López-Sendón, JL, Lopes, RD, Siegbahn, A, Granger, CB, and Wallentin, L. "Efficacy and Safety of Apixaban Compared With Warfarin in Patients With Atrial Fibrillation in Relation to Renal Function Over Time: Insights From the ARISTOTLE Randomized Clinical Trial." Jama Cardiology 1, no. 4 (July 2016): 451-460.

PMID
27438322
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Jaspers Focks, J, Brouwer, MA, Wojdyla, DM, Thomas, L, Lopes, RD, Washam, JB, Lanas, F, Xavier, D, Husted, S, Wallentin, L, Alexander, JH, Granger, CB, and Verheugt, FWA. "Polypharmacy and effects of apixaban versus warfarin in patients with atrial fibrillation: post hoc analysis of the ARISTOTLE trial." BMJ (Clinical research ed.) 353 (June 15, 2016): i2868-.

PMID
27306620
Full Text

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