John J. Strouse, MD, PhD

Associate Professor of Medicine
Associate Professor in the Department of Pediatrics
Email address john.strouse@duke.edu

My research has focused on the epidemiology, risk factors, and prevention of the pulmonary and central nervous system complications of sickle cell disease and includes retrospective and prospective cohort studies and clinical trials.  I received my Ph.D. in clinical investigation from the Johns Hopkins Bloomberg School of Public Health for a series of studies to identify predictors of cognitive function in children with sickle cell disease.  This work has expanded to the evaluation of the interaction between environment and disease in both children and adults with sickle cell disease.  My other research interests include the application of large clinical, research, and administrative databases to the study of rare hematological diseases and interventions to improve quality of and access to care for sickle cell disease. I serve on the American Society of Hematology Sickle Cell Taskforce and Sickle Cell Pain Guideline Panel and am co-chair of the American Society of Hematology Healthcare Professional Education and Training Work Group.

 

Education and Training

  • Fellow in Pediatric Hematology, Nci, National Institutes of Health, 2001 - 2004
  • Fellow in Pediatric Hematology/Oncology, Johns Hopkins University, 2001 - 2004
  • Fellow in Hematology, Nhlbi, National Institutes of Health, 2000 - 2004
  • Combined Internal Medicine/Pediatrics Residency, University of Rochester, 1996 - 2000
  • Ph.D., Johns Hopkins University, 2009
  • M.D., Johns Hopkins University School of Medicine, 1996

Publications

Brandow, Amanda M., C Patrick Carroll, Susan Creary, Ronisha Edwards-Elliott, Jeffrey Glassberg, Robert W. Hurley, Abdullah Kutlar, et al. “American Society of Hematology 2020 guidelines for sickle cell disease: management of acute and chronic pain.” Blood Adv 4, no. 12 (June 23, 2020): 2656–2701. https://doi.org/10.1182/bloodadvances.2020001851.

PMID
32559294
Full Text

Farooq, Faheem, Peter J. Mogayzel, Sophie Lanzkron, Carlton Haywood, and John J. Strouse. “Comparison of US Federal and Foundation Funding of Research for Sickle Cell Disease and Cystic Fibrosis and Factors Associated With Research Productivity.” Jama Netw Open 3, no. 3 (March 2, 2020): e201737. https://doi.org/10.1001/jamanetworkopen.2020.1737.

PMID
32219405
Full Text

Li, Wenbo, Xiang Xu, Peiying Liu, John J. Strouse, James F. Casella, Hanzhang Lu, Peter C. M. van Zijl, and Qin Qin. “Quantification of whole-brain oxygenation extraction fraction and cerebral metabolic rate of oxygen consumption in adults with sickle cell anemia using individual T2 -based oxygenation calibrations.” Magn Reson Med 83, no. 3 (March 2020): 1066–80. https://doi.org/10.1002/mrm.27972.

PMID
31483528
Full Text

Farrell, Ann T., Julie Panepinto, C Patrick Carroll, Deepika S. Darbari, Ankit A. Desai, Allison A. King, Robert J. Adams, et al. “End points for sickle cell disease clinical trials: patient-reported outcomes, pain, and the brain.” Blood Adv 3, no. 23 (December 10, 2019): 3982–4001. https://doi.org/10.1182/bloodadvances.2019000882.

PMID
31809538
Full Text

Darbari, Isha, Emily Jacobs, Olivia Gordon, Diane Weiss, Kim Winship, James F. Casella, John J. Strouse, and Clifford M. Takemoto. “Correlates of successful transition in young adults with sickle cell disease.” Pediatr Blood Cancer 66, no. 12 (December 2019): e27939. https://doi.org/10.1002/pbc.27939.

PMID
31429531
Full Text

Oyedeji, Charity I., Carl Pieper, Katherine Hall, Miriam Morey, Heather Whitson, and John J. Strouse. “Assessing Feasibility of a Focused Geriatric Assessment in Older Adults with Sickle Cell Disease to Address Functional Risk Factors for Morbidity and Mortality.” Blood 134, no. Supplement_1 (November 13, 2019): 518–518. https://doi.org/10.1182/blood-2019-122634.

Full Text

Oyedeji, Charity, John Joseph Strouse, Regina D. Crawford, Melanie E. Garrett, Allison E. Ashley-Koch, and Marilyn J. Telen. “A multi-institutional comparison of younger and older adults with sickle cell disease.” Am J Hematol 94, no. 4 (April 2019): E115–17. https://doi.org/10.1002/ajh.25405.

PMID
30663090
Full Text

Casella, James F., Robert J. Adams, Donald J. Brambilla, John J. Strouse, Pia Maier, Rachel Dlugash, Radhika Avadhani, et al. “Developing a risk-based composite neurologic outcome for a trial of hydroxyurea in young children with sickle cell disease.” Clin Trials 16, no. 1 (February 2019): 20–31. https://doi.org/10.1177/1740774518807160.

PMID
30426764
Full Text

Farooq, Faheem, and John J. Strouse. “Disparities in Foundation and Federal Support and Development of New Therapeutics for Sickle Cell Disease and Cystic Fibrosis.” In Blood, 132:4687–4687. American Society of Hematology, 2018. https://doi.org/10.1182/blood-2018-99-115609.

Full Text

Pages