Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Parsons, Elizabeth, L Kristin Newby, Manjushri V. Bhapkar, Karen P. Alexander, Harvey D. White, Svati H. Shah, Cheryl D. Bushnell, Robert M. Califf, and Robert M. Symphony and 2nd Symphony Investigators. “Postmenopausal hormone use in women with acute coronary syndromes..” J Womens Health (Larchmt) 13, no. 8 (October 2004): 863–71. https://doi.org/10.1089/jwh.2004.13.863.

PMID
15671702
Full Text

Peterson, Eric D., Karen P. Alexander, David J. Malenka, Edward L. Hannan, Gerald T. O’Conner, Ben D. McCallister, William S. Weintraub, Fred L. Grover, and Fred L. American Heart Association Chronic CAD Working Group. “Multicenter experience in revascularization of very elderly patients..” Am Heart J 148, no. 3 (September 2004): 486–92. https://doi.org/10.1016/j.ahj.2004.03.039.

PMID
15389237
Full Text

Lytle, Barbara L., Gregory J. Shook, Karen P. Alexander, Patricia A. Cowper, Daniel B. Mark, and Elizabeth R. DeLong. “1153-74 Physician counseling can influence health-related quality of life.” In Journal of the American College of Cardiology, 43:A418–A418. Elsevier BV, 2004. https://doi.org/10.1016/s0735-1097(04)91763-9.

Full Text

Alexander, Karen P., and Mimi S. Biswas. “Heart failure and the elderly: disease diversity, data, and delivery of care..” Am Heart J 146, no. 2 (August 2003): 194–96. https://doi.org/10.1016/S0002-8703(03)00190-X.

PMID
12891180
Full Text

Jones, D. L., M. Ishii, A. LaPerriere, H. Stanley, M. Antoni, G. Ironson, N. Schneiderman, et al. “Influencing medication adherence among women with AIDS..” Aids Care 15, no. 4 (August 2003): 463–74. https://doi.org/10.1080/0954012031000134700.

PMID
14509861
Full Text

Lytle, B. L., L. P. Coombs, G. J. Shook, P. A. Cowper, K. P. Alexander, E. D. Peterson, D. B. Mark, and E. R. DeLong. “Home health care for coronary artery disease patients impacts quality of life.” In Journal of the American College of Cardiology, 41:521A-521A. ELSEVIER SCIENCE INC, 2003.

Scholars@Duke

Alexander, K. P., B. Lytle, Y. Li, and E. Peterson. “Elderly patients have better functioning, less angina at one year with coronary artery bypass graft.” In Journal of the American College of Cardiology, 41:220A-221A. ELSEVIER SCIENCE INC, 2003.

Scholars@Duke

Alexander, K. P., T. Harding, L. Coombs, and E. Peterson. “Are patients properly informed prior to revascularization decisions?.” In Journal of the American College of Cardiology, 41:535A-535A. ELSEVIER SCIENCE INC, 2003.

Scholars@Duke

Shah, S. H., K. P. Alexander, and E. D. Peterson. “PCI in women.” Cardiology Review 20, no. 3 (March 1, 2003): 24–29.

Scholars@Duke

Pages