Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Alexander, KP, Mulgund, J, Lytle, B, and Peterson, E. "Long-term implications of discharge anemia in a cardiovascular population." May 30, 2006.

Scholars@Duke

Alexander, KP, and Peterson, ED. "In reply [6]." Journal of the American Medical Association 295, no. 16 (April 26, 2006): 1897-null. (Letter)

Full Text

Peterson, ED, Chen, AY, Alexander, KP, LaPointe, NMA, Fraulo, ES, Newby, LK, Roe, MT, Gibler, WB, and Ohman, EM. "The association between hospital guideline adherence, dosing safety, and patient outcomes: Results from the CRUSADE quality improvement initiative." February 21, 2006.

Scholars@Duke

LaPointe, NMA, Alexander, KP, Chen, AY, Roe, MT, Pollack, CV, Ohman, EM, Gibler, WB, and Peterson, ED. "Enoxaparin dosing and bleeding in real world practice: Results from CRUSADE." February 21, 2006.

Scholars@Duke

Alexander, KP, and Peterson, ED. "Treatment of non-ST-elevation acute coronary syndrome in the elderly: current practice and future opportunities." The American Journal of Geriatric Cardiology 15, no. 1 (January 2006): 42-49. (Review)

PMID
16415646
Full Text

Kulkarni, SP, Alexander, KP, Lytle, B, Heiss, G, and Peterson, ED. "Long-term adherence with cardiovascular drug regimens." American Heart Journal 151, no. 1 (January 2006): 185-191.

PMID
16368315
Full Text

Alexander, KP, Chen, AY, Roe, MT, Newby, LK, Gibson, CM, Allen-LaPointe, NM, Pollack, C, Gibler, WB, Ohman, EM, Peterson, ED, and CRUSADE Investigators, . "Excess dosing of antiplatelet and antithrombin agents in the treatment of non-ST-segment elevation acute coronary syndromes." Jama 294, no. 24 (December 2005): 3108-3116.

PMID
16380591
Full Text

Alexander, KP, Chen, AY, Roe, MT, Newby, LK, Gibson, CM, Schwartz, J, Hochman, JS, Redberg, RF, Ohman, EM, Gibler, WB, and Peterson, ED. "Sex differences in glycoprotein 11b/111a inhibitor dosing and bleeding in acute coronary syndromes: Results from CRUSADE." October 25, 2005.

Scholars@Duke

Melloni, C, Roe, MT, Milford-Boland, S, Alexander, KP, Newby, LK, Szczech, LA, Pollack, CV, Kirk, JD, Christenson, RH, Harrington, RA, Gibler, WB, Ohman, EM, Fesmire, FM, and Peterson, ED. "Renal insufficiency, troponin, and risk of death among patients with non-ST-segment elevation acute coronary syndromes." October 25, 2005.

Scholars@Duke

Yang, X, Alexander, KP, Chen, AY, Roe, MT, Brindis, RG, Rao, SV, Gibler, WB, Ohman, EM, Peterson, ED, and CRUSADE Investigators, . "The implications of blood transfusions for patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE National Quality Improvement Initiative." Journal of the American College of Cardiology 46, no. 8 (October 2005): 1490-1495.

PMID
16226173
Full Text

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