Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992


Shen, L, Shah, BR, Nam, A, Holmes, D, Alexander, KP, Bhatt, DL, Ho, PM, Peterson, ED, He, B, and Roe, MT. "Implications of prior myocardial infarction for patients presenting with an acute myocardial infarction." American Heart Journal 167, no. 6 (January 1, 2014): 840-845.

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Lindman, BR, Alexander, KP, O'Gara, PT, and Afilalo, J. "Futility, benefit, and transcatheter aortic valve replacement." JACC: Cardiovascular Interventions 7, no. 7 (January 1, 2014): 707-716. (Review)

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Kontos, MC, Rennyson, SL, Chen, AY, Alexander, KP, Peterson, ED, and Roe, MT. "The association of myocardial infarction process of care measures and in-hospital mortality: A report from the NCDR®." American Heart Journal 168, no. 5 (January 1, 2014): 766-775.

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Lytle, BL, Li, S, Lofthus, DM, Thomas, L, Poteat, JL, Bhatt, DL, Cannon, CP, Fonarow, GC, Peterson, ED, Wang, TY, and Alexander, KP. "Targeted versus standard feedback: Results froma RandomizedQuality Improvement Trial." American Heart Journal 169, no. 1 (January 1, 2014): 132-141.e2.

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O'Brien, EC, Fosbol, EL, Peng, SA, Alexander, KP, Roe, MT, and Peterson, ED. "Association of body mass index and long-term outcomes in older patients with non-ST-segment-elevation myocardial infarction: results from the CRUSADE Registry." Circ Cardiovasc Qual Outcomes 7, no. 1 (January 2014): 102-109.

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Waldo, SW, Brenner, DA, Li, S, Alexander, K, and Ganz, P. "Reperfusion times and in-hospital outcomes among patients with an isolated posterior myocardial infarction: Insights from the National Cardiovascular Data Registry (NCDR)." American Heart Journal 167, no. 3 (2014): 350-354.

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Weisz, G, Farzaneh-Far, R, Ben-Yehuda, O, Debruyne, B, Montalescot, G, Lerman, A, Mahmud, E, Alexander, KP, Ohman, EM, White, HD, Olmsted, A, Walker, GA, and Stone, GW. "Use of ranolazine in patients with incomplete revascularization after percutaneous coronary intervention: Design and rationale of the Ranolazine for Incomplete Vessel Revascularization Post-Percutaneous Coronary Intervention (RIVER-PCI) trial." American Heart Journal 166, no. 6 (December 1, 2013).

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Desai, NR, Peterson, ED, Chen, AY, Wiviott, SD, Sabatine, MS, Alexander, KP, Roe, MT, and Shah, BR. "Balancing the risk of mortality and major bleeding in the treatment of NSTEMI patients - A report from the National Cardiovascular Data Registry." American Heart Journal 166, no. 6 (December 1, 2013).

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Shen, L, Peterson, ED, Li, S, Thomas, L, Alexander, K, Xian, Y, Wang, TY, Roe, MT, He, B, and Shah, BR. "The association between smoking and long-term outcomes after non-ST-segment elevation myocardial infarction in older patients." American Heart Journal 166, no. 6 (December 1, 2013): 1056-1062.

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Bagai, A, Wang, Y, Wang, TY, Curtis, J, Gurm, HS, Peterson, ED, Saucedo, JF, Granger, CB, Roe, MT, Bhatt, DL, McNamara, RL, and Alexander, KP. "In-Hospital ADP Receptor Inhibitor Switching in Myocardial Infarction Patients Treated With Percutaneous Coronary Intervention: Insights From the National Cardiovascular Data Registry (R)." November 26, 2013.