Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Waldo, SW, Brenner, DA, Li, S, Alexander, K, and Ganz, P. "Reperfusion times and in-hospital outcomes among patients with an isolated posterior myocardial infarction: Insights from the National Cardiovascular Data Registry (NCDR)." American Heart Journal 167, no. 3 (2014): 350-354.

Full Text

Weisz, G, Farzaneh-Far, R, Ben-Yehuda, O, Debruyne, B, Montalescot, G, Lerman, A, Mahmud, E, Alexander, KP, Ohman, EM, White, HD, Olmsted, A, Walker, GA, and Stone, GW. "Use of ranolazine in patients with incomplete revascularization after percutaneous coronary intervention: Design and rationale of the Ranolazine for Incomplete Vessel Revascularization Post-Percutaneous Coronary Intervention (RIVER-PCI) trial." American Heart Journal 166, no. 6 (December 1, 2013).

Full Text

Desai, NR, Peterson, ED, Chen, AY, Wiviott, SD, Sabatine, MS, Alexander, KP, Roe, MT, and Shah, BR. "Balancing the risk of mortality and major bleeding in the treatment of NSTEMI patients - A report from the National Cardiovascular Data Registry." American Heart Journal 166, no. 6 (December 1, 2013).

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Shen, L, Peterson, ED, Li, S, Thomas, L, Alexander, K, Xian, Y, Wang, TY, Roe, MT, He, B, and Shah, BR. "The association between smoking and long-term outcomes after non-ST-segment elevation myocardial infarction in older patients." American Heart Journal 166, no. 6 (December 1, 2013): 1056-1062.

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Bagai, A, Wang, Y, Wang, TY, Curtis, J, Gurm, HS, Peterson, ED, Saucedo, JF, Granger, CB, Roe, MT, Bhatt, DL, McNamara, RL, and Alexander, KP. "In-Hospital ADP Receptor Inhibitor Switching in Myocardial Infarction Patients Treated With Percutaneous Coronary Intervention: Insights From the National Cardiovascular Data Registry (R)." November 26, 2013.

Scholars@Duke

Dodson, JA, Wang, Y, Alexander, KP, Masoudi, F, Spertus, JA, Chaudhry, SI, Chen, I, Nallamothu, BK, Arnold, SV, Dharmarajan, K, Shi, R, and Krumholz, HM. "National Trends in Rehospitalization for Bleeding After Acute Myocardial Infarction in Older Patients, 1999-2010." November 26, 2013.

Scholars@Duke

Shen, L, Li, S, Thomas, L, Wang, TY, Alexander, KP, Shah, B, Peterson, E, and Roe, MT. "The Association of Transfer-out Rates from Hospitals Without Revascularization Capabilities and Long-term Mortality Risk Among Older Nstemi Patients." November 26, 2013.

Scholars@Duke

Alexander, KP, Kong, DF, Starr, AZ, Kramer, J, Chiswell, K, Tasneem, A, and Califf, RM. "Portfolio of clinical research in adult cardiovascular disease as reflected in ClinicalTrials.gov. (Published online)" J Am Heart Assoc 2, no. 5 (September 26, 2013): e000009-.

PMID
24072529
Full Text

Bernacki, GM, and Alexander, KP. "Aortic stenosis: What long-term care providers need to know." Annals of Long-Term Care 21, no. 9 (September 1, 2013): 22-27. (Review)

Scholars@Duke

Roe, MT, Li, S, Thomas, L, Wang, TY, Alexander, KP, Ohman, EM, and Peterson, ED. "Long-term outcomes after invasive management for older patients with non-ST-segment elevation myocardial infarction." Circ Cardiovasc Qual Outcomes 6, no. 3 (May 1, 2013): 323-332.

PMID
23652734
Full Text

Pages