Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Lindman, Brian R., Karen P. Alexander, Patrick T. O’Gara, and Jonathan Afilalo. “Futility, benefit, and transcatheter aortic valve replacement..” Jacc Cardiovasc Interv 7, no. 7 (July 2014): 707–16. https://doi.org/10.1016/j.jcin.2014.01.167.

PMID
24954571
Full Text

Beatty, Alexis L., Shuang Li, Laine Thomas, Ezra A. Amsterdam, Karen P. Alexander, and Mary A. Whooley. “Trends in referral to cardiac rehabilitation after myocardial infarction: data from the National Cardiovascular Data Registry 2007 to 2012..” J Am Coll Cardiol 63, no. 23 (June 17, 2014): 2582–83. https://doi.org/10.1016/j.jacc.2014.03.030.

PMID
24768872
Full Text

Wang, Tracy Y., David J. Magid, Henry H. Ting, Shuang Li, Karen P. Alexander, Matthew T. Roe, and Eric D. Peterson. “The quality of antiplatelet and anticoagulant medication administration among ST-segment elevation myocardial infarction patients transferred for primary percutaneous coronary intervention..” Am Heart J 167, no. 6 (June 2014): 833–39. https://doi.org/10.1016/j.ahj.2014.03.002.

PMID
24890532
Full Text

Shen, Lan, Bimal R. Shah, Aro Nam, DaJuanicia Holmes, Karen P. Alexander, Deepak L. Bhatt, P Michael Ho, Eric D. Peterson, Ben He, and Matthew T. Roe. “Implications of prior myocardial infarction for patients presenting with an acute myocardial infarction..” Am Heart J 167, no. 6 (June 2014): 840–45. https://doi.org/10.1016/j.ahj.2014.03.009.

PMID
24890533
Full Text

O’Brien, Emily, Sumeet Subherwal, Matthew T. Roe, DaJuanicia N. Holmes, Laine Thomas, Karen P. Alexander, Tracy Y. Wang, and Eric D. Peterson. “Do patients treated at academic hospitals have better longitudinal outcomes after admission for non-ST-elevation myocardial infarction?.” Am Heart J 167, no. 5 (May 2014): 762–69. https://doi.org/10.1016/j.ahj.2014.01.009.

PMID
24766988
Full Text

Afilalo, Jonathan, Karen P. Alexander, Michael J. Mack, Mathew S. Maurer, Philip Green, Larry A. Allen, Jeffrey J. Popma, Luigi Ferrucci, and Daniel E. Forman. “Frailty assessment in the cardiovascular care of older adults..” J Am Coll Cardiol 63, no. 8 (March 4, 2014): 747–62. https://doi.org/10.1016/j.jacc.2013.09.070.

PMID
24291279
Full Text

Dodson, J. A., Y. Wang, S. I. Chaudhry, K. P. Alexander, F. A. Masoudi, J. A. Spertus, B. Nallamothu, et al. “National trends in rehospitalization for bleeding after acute myocardial infarction in the oldest old.” In Journal of the American Geriatrics Society, 62:S41–S41. WILEY-BLACKWELL, 2014.

Scholars@Duke

Xian, Ying, Anita Y. Chen, Laine Thomas, Matthew T. Roe, Sumeet Subherwal, Christopher P. Cannon, Charles V. Pollack, et al. “Sources of hospital-level variation in major bleeding among patients with non-st-segment elevation myocardial infarction: a report from the National Cardiovascular Data Registry (NCDR)..” Circ Cardiovasc Qual Outcomes 7, no. 2 (March 2014): 236–43. https://doi.org/10.1161/CIRCOUTCOMES.113.000715.

PMID
24594548
Full Text

Waldo, Stephen W., Daniel A. Brenner, Shuang Li, Karen Alexander, and Peter Ganz. “Reperfusion times and in-hospital outcomes among patients with an isolated posterior myocardial infarction: insights from the National Cardiovascular Data Registry (NCDR)..” Am Heart J 167, no. 3 (March 2014): 350–54. https://doi.org/10.1016/j.ahj.2013.11.011.

PMID
24576519
Full Text

Diepen, Sean van, Anita Y. Chen, Tracy Y. Wang, Karen P. Alexander, Justin A. Ezekowitz, Eric D. Peterson, and Matthew T. Roe. “Influence of heart failure symptoms and ejection fraction on short- and long-term outcomes for older patients with non-ST-segment elevation myocardial infarction..” Am Heart J 167, no. 2 (February 2014): 267-273.e1. https://doi.org/10.1016/j.ahj.2013.11.005.

PMID
24439989
Full Text

Pages