Geriatrics

Kenneth Edwin Schmader, MD

Professor of Medicine
Director of the GRECC and ACOS for Geriatrics and Extended Care
Senior Fellow in the Center for the Study of Aging and Human Development
Campus mail Duke Box 3469, Durham, NC 27710
Phone (919) 660-7572
Email address kenneth.schmader@duke.edu

Dr. Schmader’s areas of research include herpes zoster, infections, and vaccines in older adults.  He conducts translational, clinical trials and observational studies of zoster, influenza, and other infections funded by grants from the National Institute on Aging (NIA), National Institute of Allergy and Infectious Diseases (NIAID), Centers for Disease Control (CDC), VA Office of Research and Development, and Industry sources.  He has played a pivotal role in the development of zoster vaccines in older adults.  Dr. Schmader also performs research in medications and older adults, focusing on pharmacoepidemiology, optimal drug use and reduction of adverse drug reactions.

He is the Director of the NIA-funded P30 Duke Pepper Older Americans Independence Center and Co-PI of the NIAID funded Vaccine and Therapeutics Effectiveness Unit (VTEU) at Duke.  He serves on the Working Groups for the Herpes Zoster, Influenza, and General Adult Immunization Guidelines for the US Centers for Disease Control (CDC) Advisory Committee on Immunization Practices (ACIP) and is the American Geriatrics Society liaison to the ACIP.

Education and Training

  • Fellow in Geriatrics, Medicine, Duke University, 1986 - 1988
  • Chief Medical Resident, Medicine, University of Wisconsin - Madison, 1983 - 1983
  • Medical Resident, Medicine, University of Wisconsin - Madison, 1980 - 1983
  • M.D., Wake Forest University, 1980

Grants

Publications

Steinman, Michael A., Cynthia M. Boyd, and Kenneth E. Schmader. “Expanding Evidence for Clinical Care of Older Adults: Beyond Clinical Trial Traditions and Finding New Approaches.” Jama 326, no. 6 (August 10, 2021): 475–76. https://doi.org/10.1001/jama.2021.12134.

PMID
34292309
Full Text

Whitson, Heather E., Donna Crabtree, Carl F. Pieper, Christine Ha, Sandra Au, Miles Berger, Harvey J. Cohen, et al. “A template for physical resilience research in older adults: Methods of the PRIME-KNEE study.” J Am Geriatr Soc, July 29, 2021. https://doi.org/10.1111/jgs.17384.

PMID
34325481
Full Text

Herati, Ramin Sedaghat, Luisa Victoria Silva, Laura A. Vella, Alexander Muselman, Cecile Alanio, Bertram Bengsch, Raj K. Kurupati, et al. “Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways.” Cell Rep Med 2, no. 5 (May 18, 2021): 100262. https://doi.org/10.1016/j.xcrm.2021.100262.

PMID
34095875
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Curran, Desmond, Joon H. Kim, Sean Matthews, Christophe Dessart, Myron J. Levin, Lidia Oostvogels, Megan E. Riley, et al. “Recombinant Zoster Vaccine Is Efficacious and Safe in Frail Individuals.” J Am Geriatr Soc 69, no. 3 (March 2021): 744–52. https://doi.org/10.1111/jgs.16917.

PMID
33197294
Full Text

Schmader, Kenneth E., Myron J. Levin, Michael Chen, Sean Matthews, Megan E. Riley, Wayne Woo, Caroline Hervé, et al. “Impact of Reactogenicity After Two Doses of Recombinant Zoster Vaccine Upon Physical Functioning and Quality of Life: An Open Phase III Trial in Older Adults.” J Gerontol a Biol Sci Med Sci 76, no. 3 (February 25, 2021): 485–90. https://doi.org/10.1093/gerona/glaa127.

PMID
32530462
Full Text

Winokur, Patricia, Hana M. El Sahly, Mark J. Mulligan, Sharon E. Frey, Richard Rupp, Evan J. Anderson, Kathryn M. Edwards, et al. “Immunogenicity and safety of different dose schedules and antigen doses of an MF59-adjuvanted H7N9 vaccine in healthy adults aged 65 years and older.” Vaccine 39, no. 8 (February 22, 2021): 1339–48. https://doi.org/10.1016/j.vaccine.2020.11.051.

PMID
33485646
Full Text

Ailabouni, Nagham J., Zachary A. Marcum, Kenneth E. Schmader, and Shelly L. Gray. “Medication Use Quality and Safety in Older Adults: 2019 Update.” J Am Geriatr Soc 69, no. 2 (February 2021): 336–41. https://doi.org/10.1111/jgs.17018.

PMID
33438206
Full Text

Schmader, Kenneth E., Christine K. Liu, Theresa Harrington, Wes Rountree, Heidi Auerbach, Emmanuel B. Walter, Elizabeth D. Barnett, et al. “Safety, Reactogenicity, and Health-Related Quality of Life After Trivalent Adjuvanted vs Trivalent High-Dose Inactivated Influenza Vaccines in Older Adults: A Randomized Clinical Trial.” Jama Network Open 4, no. 1 (January 4, 2021): e2031266. https://doi.org/10.1001/jamanetworkopen.2020.31266.

PMID
33443580
Full Text

Callahan, Kathryn E., Malaz Boustani, Lauren Ferrante, Daniel E. Forman, Jerry Gurwitz, Kevin P. High, Frances McFarland, et al. “Embedding and Sustaining a Focus on Function in Specialty Research and Care.” J Am Geriatr Soc 69, no. 1 (January 2021): 225–33. https://doi.org/10.1111/jgs.16860.

PMID
33064303
Full Text

Andrew, Melissa K., Kenneth E. Schmader, Kenneth Rockwood, Barry Clarke, and Janet E. McElhaney. “Considering Frailty in SARS-CoV-2 Vaccine Development: How Geriatricians Can Assist.” Clin Interv Aging 16 (2021): 731–38. https://doi.org/10.2147/CIA.S295522.

PMID
33953551
Full Text

Pages