Kenneth Ward Lyles, MD

Professor of Medicine
Senior Fellow in the Center for the Study of Aging and Human Development
Campus mail Duke Box 3881, Durham, NC 27710
Phone (919) 660-7520
Email address kenneth.lyles@duke.edu

My research activities focus on understanding ways that osteoporotic fractures affect people and trying to learn ways to reduce their impact on affected individuals and prevent further fractures. I have worked with patient with hip and vertebral fractures, gaining insight into the impairments such fractures cause. Also we have learned that a hip fracture is a major risk factor for subsequent fractures after the initial hip fracture. Our group completed a randomized, placebo-controlled trial that we designed with Novartis Pharmaceutical Corporation showing, that an annual infusion of a 5mg of the bisphosphonate zoledronic acid reduced subsequent fractures after a surgical procedure for a hip fracture by 35% when compared to a place infusion (New England Journal of Medicine, 11-1-07). In this study we also observed a 28% reduction in death in the zoledronic acid treated patients. Other research groups have shown that oral bisphosphonates also reduce mortality in patients with osteoporosis. Currently, we, with a number of collaborators, are conducting both animal and human studies to better understand this beneficial effect upon mortality.

In other work, our group tries to understand how other diseases such as strokes and spinal cord injury, and medications such as anticonvulsants place patients at risk for fractures. As we understand the epidemiology of these types of fractures, we plan to develop intervention trials to test whether we can reduce the occurrence of these fractures.

In addition to the above described work our group has help design and conduct a number of phase 1,2 and 3 clinical trials in Paget's disease of Bone and osteoporosis.

KEY WORDS:
Oteoporosis
Hip and vertebra fractures
Paget's disease of bone
Mobility impairments from metabolic bone diseases
Bisphosphonates

Education and Training

  • M.D., Virginia Commonwealth University, 1974

Publications

Sagalla, Nicole, Richard Lee, Richard Sloane, Kenneth Lyles, and Cathleen Colón-Emeric. “Factors Associated With Adherence to Osteoporosis Medications Among Male Veterans.” In Jbmr Plus, 5:e10498, 2021. https://doi.org/10.1002/jbm4.10498.

PMID
34368605
Full Text

Lyles, K. W., D. C. Bauer, C. S. Colon-Emeric, C. F. Pieper, S. R. Cummings, and D. M. Black. “Zoledronic acid reduces the rate of clinical fractures after surgical repair of a hip fracture regardless of the Pretreatment bone mineral density.” Osteoporos Int 32, no. 6 (June 2021): 1217–19. https://doi.org/10.1007/s00198-021-05923-5.

PMID
33903925
Full Text

Miller, Marshall G., Kathryn N. Porter Starr, Jamie Rincker, Melissa C. Orenduff, Shelley R. McDonald, Carl F. Pieper, Angela R. Fruik, Kenneth W. Lyles, and Connie W. Bales. “Rationale and Design for a Higher (Dairy) Protein Weight Loss Intervention That Promotes Muscle Quality and Bone Health in Older Adults with Obesity: A Randomized, Controlled Pilot Study.” J Nutr Gerontol Geriatr 40, no. 2–3 (April 2021): 150–70. https://doi.org/10.1080/21551197.2021.1896615.

PMID
33719918
Full Text

Tanner, Caroline M., Steven R. Cummings, Michael A. Schwarzschild, Ethan G. Brown, E Ray Dorsey, Alberto J. Espay, Nicholas B. Galifianakis, et al. “The TOPAZ study: a home-based trial of zoledronic acid to prevent fractures in neurodegenerative parkinsonism.” Npj Parkinsons Dis 7, no. 1 (March 1, 2021): 16. https://doi.org/10.1038/s41531-021-00162-1.

PMID
33649343
Full Text

Sagalla, N., C. Colón-Emeric, R. Sloane, K. Lyles, J. Vognsen, and R. Lee. “FRAX without BMD can be used to risk-stratify Veterans who recently sustained a low trauma non-vertebral/non-hip fracture.” Osteoporos Int 32, no. 3 (March 2021): 467–72. https://doi.org/10.1007/s00198-020-05616-5.

PMID
32885318
Full Text

Sagalla, Nicole, Richard Lee, Kenneth Lyles, Julie Vognsen, and Cathleen Colón-Emeric. “Extent of and reasons for osteoporosis medication non-adherence among veterans and feasibility of a pilot text message reminder intervention.” In Arch Osteoporos, 16:21, 2021. https://doi.org/10.1007/s11657-021-00889-7.

PMID
33527160
Full Text

Reid, Ian R., Jonathan R. Green, Kenneth W. Lyles, David M. Reid, Ulrich Trechsel, David J. Hosking, Dennis M. Black, Steven R. Cummings, R Graham G. Russell, and Erik F. Eriksen. “Zoledronate.” Bone 137 (August 2020): 115390. https://doi.org/10.1016/j.bone.2020.115390.

PMID
32353565
Full Text

Ogunwale, Abayomi N., Cathleen S. Colon-Emeric, Richard Sloane, Robert A. Adler, Kenneth W. Lyles, and Richard H. Lee. “Acetylcholinesterase Inhibitors Are Associated with Reduced Fracture Risk among Older Veterans with Dementia.” J Bone Miner Res 35, no. 3 (March 2020): 440–45. https://doi.org/10.1002/jbmr.3916.

PMID
31711264
Full Text

Lee, Richard H., Richard Sloane, Carl Pieper, Kenneth W. Lyles, Robert A. Adler, Courtney Van Houtven, Joanne LaFleur, and Cathleen Colón-Emeric. “Glycemic Control and Insulin Treatment Alter Fracture Risk in Older Men With Type 2 Diabetes Mellitus.” J Bone Miner Res 34, no. 11 (November 2019): 2045–51. https://doi.org/10.1002/jbmr.3826.

PMID
31269274
Full Text

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