Kenneth Ward Lyles, MD

Professor of Medicine
Senior Fellow in the Center for the Study of Aging and Human Development
Campus mail Duke Box 3881, Durham, NC 27710
Phone (919) 660-7520
Email address kenneth.lyles@duke.edu

My research activities focus on understanding ways that osteoporotic fractures affect people and trying to learn ways to reduce their impact on affected individuals and prevent further fractures. I have worked with patient with hip and vertebral fractures, gaining insight into the impairments such fractures cause. Also we have learned that a hip fracture is a major risk factor for subsequent fractures after the initial hip fracture. Our group completed a randomized, placebo-controlled trial that we designed with Novartis Pharmaceutical Corporation showing, that an annual infusion of a 5mg of the bisphosphonate zoledronic acid reduced subsequent fractures after a surgical procedure for a hip fracture by 35% when compared to a place infusion (New England Journal of Medicine, 11-1-07). In this study we also observed a 28% reduction in death in the zoledronic acid treated patients. Other research groups have shown that oral bisphosphonates also reduce mortality in patients with osteoporosis. Currently, we, with a number of collaborators, are conducting both animal and human studies to better understand this beneficial effect upon mortality.

In other work, our group tries to understand how other diseases such as strokes and spinal cord injury, and medications such as anticonvulsants place patients at risk for fractures. As we understand the epidemiology of these types of fractures, we plan to develop intervention trials to test whether we can reduce the occurrence of these fractures.

In addition to the above described work our group has help design and conduct a number of phase 1,2 and 3 clinical trials in Paget's disease of Bone and osteoporosis.

KEY WORDS:
Oteoporosis
Hip and vertebra fractures
Paget's disease of bone
Mobility impairments from metabolic bone diseases
Bisphosphonates

Education and Training

  • M.D., Virginia Commonwealth University, 1974

Publications

Colón-Emeric, Cathleen S., Carl F. Pieper, Courtney H. Van Houtven, Janet M. Grubber, Kenneth W. Lyles, Joanne Lafleur, and Robert A. Adler. “Limited Osteoporosis Screening Effectiveness Due to Low Treatment Rates in a National Sample of Older Men..” Mayo Clin Proc 93, no. 12 (December 2018): 1749–59. https://doi.org/10.1016/j.mayocp.2018.06.024.

PMID
30497697
Full Text

Lee, Richard H., Richard Sloane, Carl Pieper, Kenneth W. Lyles, Robert A. Adler, Courtney Van Houtven, Joanne LaFleur, and Cathleen Colón-Emeric. “Clinical Fractures Among Older Men With Diabetes Are Mediated by Diabetic Complications..” J Clin Endocrinol Metab 103, no. 1 (January 1, 2018): 281–87. https://doi.org/10.1210/jc.2017-01593.

PMID
29099931
Full Text

Abderhalden, L., F. M. Weaver, M. Bethel, H. Demirtas, S. Burns, J. Svircev, H. Hoenig, K. Lyles, S. Miskevics, and L. D. Carbone. “Response to Sabour: Dual-energy X-ray absorptiometry and fracture prediction in patients with spinal cord injuries and disorders: methodological issues..” Osteoporos Int 28, no. 7 (July 2017): 2261–62. https://doi.org/10.1007/s00198-017-4056-6.

PMID
28508089
Full Text

Abderhalden, L., F. M. Weaver, M. Bethel, H. Demirtas, S. Burns, J. Svircev, H. Hoenig, K. Lyles, S. Miskevics, and L. D. Carbone. “Dual-energy X-ray absorptiometry and fracture prediction in patients with spinal cord injuries and disorders..” Osteoporos Int 28, no. 3 (March 2017): 925–34. https://doi.org/10.1007/s00198-016-3841-y.

PMID
27924381
Full Text

Bethel, M., F. M. Weaver, L. Bailey, S. Miskevics, J. N. Svircev, S. P. Burns, H. Hoenig, K. Lyles, and L. D. Carbone. “Risk factors for osteoporotic fractures in persons with spinal cord injuries and disorders..” Osteoporos Int 27, no. 10 (October 2016): 3011–21. https://doi.org/10.1007/s00198-016-3627-2.

PMID
27230522
Full Text

Lee, Richard H., Megan Pearson, Kenneth W. Lyles, Patricia W. Jenkins, and Cathleen Colon-Emeric. “Geographic scope and accessibility of a centralized, electronic consult program for patients with recent fracture..” Rural Remote Health 16, no. 1 (January 2016).

PMID
26745338
Scholars@Duke

Colón-Emeric, Cathleen, Carl F. Pieper, Janet Grubber, Lynn Van Scoyoc, Merritt L. Schnell, Courtney Harold Van Houtven, Megan Pearson, Joanne Lafleur, Kenneth W. Lyles, and Robert A. Adler. “Correlation of hip fracture with other fracture types: Toward a rational composite hip fracture endpoint..” Bone 81 (December 2015): 67–71. https://doi.org/10.1016/j.bone.2015.07.003.

PMID
26151123
Full Text

Singer, F. R., H. G. Bone, D. J. Hosking, K. W. Lyles, I. R. Reid, and E. S. Siris. “Response to letter by Ralston et al.” The Journal of Clinical Endocrinology and Metabolism 100, no. 6 (June 1, 2015): L47–48. https://doi.org/10.1210/jc.2015-1961.

Full Text

Singer, Frederick R., Henry G. Bone, David J. Hosking, Kenneth W. Lyles, Ian R. Reid, and Ethel S. Siris. “Response to letter by Ralston et al..” J Clin Endocrinol Metab 100, no. 6 (June 2015): L47–48. https://doi.org/10.1210/jc.2015-1961.

PMID
26047081
Full Text

Pages