Kenneth Ward Lyles, MD

Professor of Medicine
Senior Fellow in the Center for the Study of Aging and Human Development
Campus mail Duke Box 3881, Durham, NC 27710
Phone (919) 660-7520
Email address kenneth.lyles@duke.edu

My research activities focus on understanding ways that osteoporotic fractures affect people and trying to learn ways to reduce their impact on affected individuals and prevent further fractures. I have worked with patient with hip and vertebral fractures, gaining insight into the impairments such fractures cause. Also we have learned that a hip fracture is a major risk factor for subsequent fractures after the initial hip fracture. Our group completed a randomized, placebo-controlled trial that we designed with Novartis Pharmaceutical Corporation showing, that an annual infusion of a 5mg of the bisphosphonate zoledronic acid reduced subsequent fractures after a surgical procedure for a hip fracture by 35% when compared to a place infusion (New England Journal of Medicine, 11-1-07). In this study we also observed a 28% reduction in death in the zoledronic acid treated patients. Other research groups have shown that oral bisphosphonates also reduce mortality in patients with osteoporosis. Currently, we, with a number of collaborators, are conducting both animal and human studies to better understand this beneficial effect upon mortality.

In other work, our group tries to understand how other diseases such as strokes and spinal cord injury, and medications such as anticonvulsants place patients at risk for fractures. As we understand the epidemiology of these types of fractures, we plan to develop intervention trials to test whether we can reduce the occurrence of these fractures.

In addition to the above described work our group has help design and conduct a number of phase 1,2 and 3 clinical trials in Paget's disease of Bone and osteoporosis.

KEY WORDS:
Oteoporosis
Hip and vertebra fractures
Paget's disease of bone
Mobility impairments from metabolic bone diseases
Bisphosphonates

Education and Training

  • M.D., Virginia Commonwealth University, 1974

Publications

Reid, Ian R., Jonathan R. Green, Kenneth W. Lyles, David M. Reid, Ulrich Trechsel, David J. Hosking, Dennis M. Black, Steven R. Cummings, R Graham G. Russell, and Erik F. Eriksen. “Zoledronate.” Bone 137 (April 27, 2020): 115390. https://doi.org/10.1016/j.bone.2020.115390.

PMID
32353565
Full Text

Ogunwale, Abayomi N., Cathleen S. Colon-Emeric, Richard Sloane, Robert A. Adler, Kenneth W. Lyles, and Richard H. Lee. “Acetylcholinesterase Inhibitors Are Associated with Reduced Fracture Risk among Older Veterans with Dementia.” J Bone Miner Res 35, no. 3 (March 2020): 440–45. https://doi.org/10.1002/jbmr.3916.

PMID
31711264
Full Text

Lee, Richard H., Richard Sloane, Carl Pieper, Kenneth W. Lyles, Robert A. Adler, Courtney Van Houtven, Joanne LaFleur, and Cathleen Colón-Emeric. “Glycemic Control and Insulin Treatment Alter Fracture Risk in Older Men With Type 2 Diabetes Mellitus.” J Bone Miner Res 34, no. 11 (November 2019): 2045–51. https://doi.org/10.1002/jbmr.3826.

PMID
31269274
Full Text

Colón-Emeric, Cathleen S., Carl F. Pieper, Courtney H. Van Houtven, Janet M. Grubber, Kenneth W. Lyles, Joanne Lafleur, and Robert A. Adler. “Limited Osteoporosis Screening Effectiveness Due to Low Treatment Rates in a National Sample of Older Men.” Mayo Clin Proc 93, no. 12 (December 2018): 1749–59. https://doi.org/10.1016/j.mayocp.2018.06.024.

PMID
30497697
Full Text

Lee, Richard H., Richard Sloane, Carl Pieper, Kenneth W. Lyles, Robert A. Adler, Courtney Van Houtven, Joanne LaFleur, and Cathleen Colón-Emeric. “Clinical Fractures Among Older Men With Diabetes Are Mediated by Diabetic Complications.” J Clin Endocrinol Metab 103, no. 1 (January 1, 2018): 281–87. https://doi.org/10.1210/jc.2017-01593.

PMID
29099931
Full Text

Abderhalden, L., F. M. Weaver, M. Bethel, H. Demirtas, S. Burns, J. Svircev, H. Hoenig, K. Lyles, S. Miskevics, and L. D. Carbone. “Response to Sabour: Dual-energy X-ray absorptiometry and fracture prediction in patients with spinal cord injuries and disorders: methodological issues.” Osteoporos Int 28, no. 7 (July 2017): 2261–62. https://doi.org/10.1007/s00198-017-4056-6.

PMID
28508089
Full Text

Abderhalden, L., F. M. Weaver, M. Bethel, H. Demirtas, S. Burns, J. Svircev, H. Hoenig, K. Lyles, S. Miskevics, and L. D. Carbone. “Dual-energy X-ray absorptiometry and fracture prediction in patients with spinal cord injuries and disorders.” Osteoporos Int 28, no. 3 (March 2017): 925–34. https://doi.org/10.1007/s00198-016-3841-y.

PMID
27924381
Full Text

Bethel, M., F. M. Weaver, L. Bailey, S. Miskevics, J. N. Svircev, S. P. Burns, H. Hoenig, K. Lyles, and L. D. Carbone. “Risk factors for osteoporotic fractures in persons with spinal cord injuries and disorders.” Osteoporosis International : A Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the Usa 27, no. 10 (October 2016): 3011–21. https://doi.org/10.1007/s00198-016-3627-2.

PMID
27230522
Full Text

Lee, Richard H., Megan Pearson, Kenneth W. Lyles, Patricia W. Jenkins, and Cathleen Colon-Emeric. “Geographic scope and accessibility of a centralized, electronic consult program for patients with recent fracture.” Rural Remote Health 16, no. 1 (January 2016): 3440.

PMID
26745338
Scholars@Duke

Pages