Lan Mao, MD

Assistant Professor in Medicine
Campus mail 231 Clin Res Lab Bldg, Durham, NC 27710
Phone (919) 668-2530
Email address

I. Research:
As the director of mouse physiology laboratory, in charge for the all events related with Dr. Howard Rockman's molecular biology laboratory studies needs.
Participate in research in rodents model:
Perform surgery and serve as co-investigator in studies on transgenic mice with heart failure. Develop models of hypertrophy in small animal using micro-surgical techniques (aortic constriction, left ventricular infarction and abdominal aortocaval fistula) and perform a variety physiological studies, obtain and analysis data on hemodynamic study and prepare tissue specimens for father molecular biological study.
Develop and apply surgical techniques for in vivo myocardial function study on small animal, such as, using new developed devices study in vivo mice cardiac function (pressure-volume lop), instrumented mice for conscious blood pressure measure or administration of medicine---carotid artery or gull duck catheterization, and conscious mice echocardiography.
Develop techniques for micro-injection of proteins and vectors in to mouse left ventricle, coronary artery and portal vein.

II. Teaching
10% of time allocated/spent---
Train postdoctoral fellows, visiting scientists and students from all over the world in laboratory procedure involving, including endotracheal intubations, cardiac catheterization, coronary occlusion and intrathoracic/intra-abdominal surgical procedures.
Teach methods of data recording and analysis using laboratory equipments and computer programs, echocardiography apply and measurement.

III. Consultant
Consult and teach microsurgical techniques related on small animals such as, rabbits, rat, hamsters and mice, like mice heart-lung transplantation, portal vein injection and mini-pump implant.
Co-laboratory with large range of Universities and Research Institutes from United States an other countries.

Education and Training

  • M.D., Beijing Medical University (China), 1979


Chang, Jae-Hyung, Seung-Yeol Paik, Lan Mao, William Eisner, Patrick J. Flannery, Liming Wang, Yuping Tang, et al. “Diabetic kidney disease in FVB/NJ Akita mice: temporal pattern of kidney injury and urinary nephrin excretion.” Plos One 7, no. 4 (2012): e33942.

Full Text

Hernandez, Alejandro, Miguel Pinilla, Jeffrey Nienaber, Lan Mao, Howard Rockman, Lucia Santacruz, and Danny O. Jacobs. “Increased intracellular creatine content is not harmful to the mouse heart.” In Faseb Journal, Vol. 25. FEDERATION AMER SOC EXP BIOL, 2011.


Grotegut, Chad A., Liping Feng, Lan Mao, R Phillips Heine, Amy P. Murtha, and Howard A. Rockman. “β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration.” Am J Physiol Endocrinol Metab 300, no. 3 (March 2011): E468–77.

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He, Wei, Lunan Zhang, Aiguo Ni, Zhiping Zhang, Maria Mirotsou, Lan Mao, Richard E. Pratt, and Victor J. Dzau. “Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction.” Proc Natl Acad Sci U S A 107, no. 49 (December 7, 2010): 21110–15.

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Derout, Jorge Espinoza, Maria Mirotsou, Zhiping Zhang, Xiyou Zhou, Lan Mao, Richard E. Pratt, Jeffery D. Molkentin, Paul Rosenberg, and Victor J. Dzau. “Impaired Cardiac Function and Heart Failure in Transgenic Mice With Cardiac Specific Overexpression of Hasf, a Novel Stem Cell Paracrine Factor.” In Circulation, Vol. 122. LIPPINCOTT WILLIAMS & WILKINS, 2010.


Piacentino, Valentino, Michael Bolanos, Jacob Schroder, Emily Messina, Edward Jones, Ava Krol, Nenad Bursac, et al. “X-Linked Inhibitor of Apoptosis Protein (XIAP)-Mediated Attenuation of Apoptosis Using a Novel Cardiac Enhanced Adeno-Associated Viral Vector.” Circulation 122, no. 21 (November 23, 2010).


McNamara, Erin R., Lan Mao, Susan Poulton, Howard A. Rockman, Trinity J. Bivalacqua, Stephen J. Freedland, and Craig F. Donatucci. “889 EFFECT OF EXERCISE ON ERECTILE FUNCTION AFTER BILATERAL NERVE CRUSH INJURY IN A RAT MODEL.” Journal of Urology 183, no. 4S (April 2010).

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McNamara, Erin, Lan Mao, Susan Poulton, Trinity Bivalacqua, Stephen J. Freedland, and Craig F. Donatucci. “EFFECT OF EXERCISE ON ERECTILE FUNCTION AFTER BILATERAL NERVE CRUSH INJURY IN A RAT MODEL.” Journal of Sexual Medicine 7 (March 1, 2010): 24–24.


Seth, Malini, Zhu-Shan Zhang, Lan Mao, Victoria Graham, Jarrett Burch, Jonathan Stiber, Leonidas Tsiokas, et al. “TRPC1 channels are critical for hypertrophic signaling in the heart.” Circ Res 105, no. 10 (November 6, 2009): 1023–30.

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Gupta, Manveen K., Afshan Hussain, Lan Mao, and Sathyamangla V Naga Prasad. “Regulation of Novel Micrornas Identified in End-stage Human Heart Failure.” In Circulation, 120:S857–58. LIPPINCOTT WILLIAMS & WILKINS, 2009.