Lan Mao, MD

Assistant Professor in Medicine
Campus mail 231 Clin Res Lab Bldg, Durham, NC 27710
Phone (919) 668-2530
Email address mao00004@mc.duke.edu

I. Research:
As the director of mouse physiology laboratory, in charge for the all events related with Dr. Howard Rockman's molecular biology laboratory studies needs.
Participate in research in rodents model:
Perform surgery and serve as co-investigator in studies on transgenic mice with heart failure. Develop models of hypertrophy in small animal using micro-surgical techniques (aortic constriction, left ventricular infarction and abdominal aortocaval fistula) and perform a variety physiological studies, obtain and analysis data on hemodynamic study and prepare tissue specimens for father molecular biological study.
Develop and apply surgical techniques for in vivo myocardial function study on small animal, such as, using new developed devices study in vivo mice cardiac function (pressure-volume lop), instrumented mice for conscious blood pressure measure or administration of medicine---carotid artery or gull duck catheterization, and conscious mice echocardiography.
Develop techniques for micro-injection of proteins and vectors in to mouse left ventricle, coronary artery and portal vein.

II. Teaching
10% of time allocated/spent---
Train postdoctoral fellows, visiting scientists and students from all over the world in laboratory procedure involving, including endotracheal intubations, cardiac catheterization, coronary occlusion and intrathoracic/intra-abdominal surgical procedures.
Teach methods of data recording and analysis using laboratory equipments and computer programs, echocardiography apply and measurement.

III. Consultant
Consult and teach microsurgical techniques related on small animals such as, rabbits, rat, hamsters and mice, like mice heart-lung transplantation, portal vein injection and mini-pump implant.
Co-laboratory with large range of Universities and Research Institutes from United States an other countries.

Education and Training

  • M.D., Beijing Medical University (China), 1979

Publications

Badea, Cristian T., Laurence W. Hedlund, Julie F Boslego Mackel, Lan Mao, Howard A. Rockman, and G Allan Johnson. “Cardiac micro-computed tomography for morphological and functional phenotyping of muscle LIM protein null mice.” Mol Imaging 6, no. 4 (July 2007): 261–68.

PMID
17711781
Scholars@Duke

Li, Ping, Richard E. Waters, Shelley I. Redfern, Mei Zhang, Lan Mao, Brian H. Annex, and Zhen Yan. “Oxidative phenotype protects myofibers from pathological insults induced by chronic heart failure in mice.” Am J Pathol 170, no. 2 (February 2007): 599–608. https://doi.org/10.2353/ajpath.2007.060505.

PMID
17255328
Full Text

Curcio, Antonio, Takahisa Noma, Sathyamangla V. Naga Prasad, Matthew J. Wolf, Anthony Lemaire, Cinzia Perrino, Lan Mao, and Howard A. Rockman. “Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling.” Am J Physiol Heart Circ Physiol 291, no. 4 (October 2006): H1754–60. https://doi.org/10.1152/ajpheart.01199.2005.

PMID
16699071
Full Text

Gurley, Susan B., Alicia Allred, Thu H. Le, Robert Griffiths, Lan Mao, Nisha Philip, Timothy A. Haystead, et al. “Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice.” J Clin Invest 116, no. 8 (August 2006): 2218–25. https://doi.org/10.1172/JCI16980.

PMID
16878172
Full Text

Perrino, Cinzia, Sathyamangla V. Naga Prasad, Lan Mao, Takahisa Noma, Zhen Yan, Hyung-Suk Kim, Oliver Smithies, and Howard A. Rockman. “Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction.” J Clin Invest 116, no. 6 (June 2006): 1547–60. https://doi.org/10.1172/JCI25397.

PMID
16741575
Full Text

Francois, H., K. Athirakul, D. Howell, R. Dash, L. Mao, H. S. Kim, H. A. Rockman, G. A. FitzGerald, B. H. Koller, and T. M. Coffman. “NSAIDs and cardiovascular risk - Reply [2].” Cell Metabolism 2, no. 6 (December 1, 2005): 339–40. https://doi.org/10.1016/j.cmet.2005.11.009.

Full Text

Francois, Helene, Krairerk Athirakul, David Howell, Rajesh Dash, Lan Mao, Hyung-Suk Kim, Howard A. Rockman, Garret A. Fitzgerald, Beverly H. Koller, and Thomas M. Coffman. “Prostacyclin protects against elevated blood pressure and cardiac fibrosis.” Cell Metab 2, no. 3 (September 2005): 201–7. https://doi.org/10.1016/j.cmet.2005.08.005.

PMID
16154102
Full Text

Chen, Zhiqiang, Matthew W. Foster, Jian Zhang, Lan Mao, Howard A. Rockman, Toshihiro Kawamoto, Kyoko Kitagawa, Keiichi I. Nakayama, Douglas T. Hess, and Jonathan S. Stamler. “An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation.” Proc Natl Acad Sci U S A 102, no. 34 (August 23, 2005): 12159–64. https://doi.org/10.1073/pnas.0503723102.

PMID
16103363
Full Text

Nassar, Rashid, Nadia N. Malouf, Lan Mao, Howard A. Rockman, Annette E. Oakeley, James R. Frye, J René Herlong, Stephen P. Sanders, and Page A. W. Anderson. “cTnT1, a cardiac troponin T isoform, decreases myofilament tension and affects the left ventricular pressure waveform.” Am J Physiol Heart Circ Physiol 288, no. 3 (March 2005): H1147–56. https://doi.org/10.1152/ajpheart.00140.2004.

PMID
15513965
Full Text

Skavdahl, Maryanne, Charles Steenbergen, James Clark, Page Myers, Tracy Demianenko, Lan Mao, Howard A. Rockman, Kenneth S. Korach, and Elizabeth Murphy. “Estrogen receptor-beta mediates male-female differences in the development of pressure overload hypertrophy.” Am J Physiol Heart Circ Physiol 288, no. 2 (February 2005): H469–76. https://doi.org/10.1152/ajpheart.00723.2004.

PMID
15374829
Full Text

Pages