Lan Mao, MD

Assistant Professor in Medicine
Campus mail 231 Clin Res Lab Bldg, Durham, NC 27710
Phone (919) 668-2530
Email address mao00004@mc.duke.edu

I. Research:
As the director of mouse physiology laboratory, in charge for the all events related with Dr. Howard Rockman's molecular biology laboratory studies needs.
Participate in research in rodents model:
Perform surgery and serve as co-investigator in studies on transgenic mice with heart failure. Develop models of hypertrophy in small animal using micro-surgical techniques (aortic constriction, left ventricular infarction and abdominal aortocaval fistula) and perform a variety physiological studies, obtain and analysis data on hemodynamic study and prepare tissue specimens for father molecular biological study.
Develop and apply surgical techniques for in vivo myocardial function study on small animal, such as, using new developed devices study in vivo mice cardiac function (pressure-volume lop), instrumented mice for conscious blood pressure measure or administration of medicine---carotid artery or gull duck catheterization, and conscious mice echocardiography.
Develop techniques for micro-injection of proteins and vectors in to mouse left ventricle, coronary artery and portal vein.

II. Teaching
10% of time allocated/spent---
Train postdoctoral fellows, visiting scientists and students from all over the world in laboratory procedure involving, including endotracheal intubations, cardiac catheterization, coronary occlusion and intrathoracic/intra-abdominal surgical procedures.
Teach methods of data recording and analysis using laboratory equipments and computer programs, echocardiography apply and measurement.

III. Consultant
Consult and teach microsurgical techniques related on small animals such as, rabbits, rat, hamsters and mice, like mice heart-lung transplantation, portal vein injection and mini-pump implant.
Co-laboratory with large range of Universities and Research Institutes from United States an other countries.

Education and Training

  • M.D., Beijing Medical University (China), 1979

Publications

Seubert, John, Baichun Yang, J Alyce Bradbury, Joan Graves, Laura M. Degraff, Scott Gabel, Rebecca Gooch, et al. “Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway.” Circ Res 95, no. 5 (September 3, 2004): 506–14. https://doi.org/10.1161/01.RES.0000139436.89654.c8.

PMID
15256482
Full Text

Caron, Kathleen M. I., Leighton R. James, Hyung-Suk Kim, Josh Knowles, Rick Uhlir, Lan Mao, John R. Hagaman, Wayne Cascio, Howard Rockman, and Oliver Smithies. “Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene.” Proc Natl Acad Sci U S A 101, no. 9 (March 2, 2004): 3106–11. https://doi.org/10.1073/pnas.0307333101.

PMID
14978280
Full Text

Nienaber, Jeffrey J., Hideo Tachibana, Sathyamangla V. Naga Prasad, Giovanni Esposito, Dianqing Wu, Lan Mao, and Howard A. Rockman. “Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure.” J Clin Invest 112, no. 7 (October 2003): 1067–79. https://doi.org/10.1172/JCI18213.

PMID
14523044
Full Text

Most, Patrick, Andrew Remppis, Sven T. Pleger, Eva Löffler, Philipp Ehlermann, Juliane Bernotat, Christiane Kleuss, et al. “Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance.” J Biol Chem 278, no. 36 (September 5, 2003): 33809–17. https://doi.org/10.1074/jbc.M301788200.

PMID
12777394
Full Text

Colomer, Josep M., Lan Mao, Howard A. Rockman, and Anthony R. Means. “Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivo.” Mol Endocrinol 17, no. 2 (February 2003): 183–92. https://doi.org/10.1210/me.2002-0350.

PMID
12554746
Full Text

Takaoka, Hideyuki, Giovanni Esposito, Lan Mao, Hiroyuki Suga, and Howard A. Rockman. “Heart size-independent analysis of myocardial function in murine pressure overload hypertrophy.” Am J Physiol Heart Circ Physiol 282, no. 6 (June 2002): H2190–97. https://doi.org/10.1152/ajpheart.00759.2001.

PMID
12003828
Full Text

Kohout, T. A., H. Takaoka, P. H. McDonald, S. J. Perry, L. Mao, R. J. Lefkowitz, and H. A. Rockman. “Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice.” Circulation 104, no. 20 (November 13, 2001): 2485–91. https://doi.org/10.1161/hc4501.098933.

PMID
11705829
Full Text

Rapacciuolo, A., G. Esposito, K. Caron, L. Mao, S. A. Thomas, and H. A. Rockman. “Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure-overload cardiac hypertrophy.” J Am Coll Cardiol 38, no. 3 (September 2001): 876–82. https://doi.org/10.1016/s0735-1097(01)01433-4.

PMID
11527648
Full Text

Knowles, J. W., G. Esposito, L. Mao, J. R. Hagaman, J. E. Fox, O. Smithies, H. A. Rockman, and N. Maeda. “Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice.” J Clin Invest 107, no. 8 (April 2001): 975–84. https://doi.org/10.1172/JCI11273.

PMID
11306601
Full Text

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