Marilyn Jo Telen, MD

Professor of Medicine
Wellcome Clinical Distinguished Professor of Medicine in Honor of R. Wayne Rundles, M.D.
Associate Professor of Pathology
Member of the Duke Cancer Institute
Affiliate, Duke Global Health Institute
Campus mail 333 Med Sci Res Bldg, Durham, NC 27710
Phone (919) 684-5378
Email address marilyn.telen@duke.edu

Dr. Telen is recognized as an expert in the biochemistry and molecular genetics of blood group antigens and the pathophysiological mechanisms of vaso-occlusion in sickle cell disease. She is the Director of the Duke Comprehensive Sickle Cell Center.

Dr. Telen's laboratory focuses on structure/function analysis of membrane proteins expressed by erythroid cells, as well as the role of these proteins in non-erythroid cells. Proteins are also studied in transfectant systems, and research focuses especially on adhesion receptors. The goals of this work are (1) to understand the mechanism and role of red cell adhesion to leukocytes and endothelium in sickle cell disease; (2) to understand the signaling mechanisms leading to activation (and inactivation) of red cell adhesion molecules; (3) to understand the molecular basis of blood group antigen expression, and (4) to understand the interactions of erythroid membrane proteins with other cells and with extracellular matrix..

Recent investigations have focused on the role of signaling pathways in the upregulation of sickle red cell adhesion. Present studies include (1) investigation of beta-adrenergic signaling pathway responsible for activation of B-CAM/LU and LW adhesion receptors; (2) understanding how nitric oxide and ATP downregulate sickle red cell adhesion; (3) studying the effect of these processes in animal models.

Dr. Telen is also involved in a large multicenter study looking for genetic polymorphisms that affect clinical outcomes in sickle cell disease, as well as a multi-center study investigating the mechanisms and treatment of pulmonary hypertension in sickle cell disease.

Key Words:

Adhesion molecules
Erythrocyte membrane
Sickle cell disease
Transfusion medicine
Immunohematology
CD44
B-CAM/LU
Genetic polymorphisms

Education and Training

  • Fellowship, Hematology/ Oncology, Duke University School of Medicine, 1980 - 1983
  • Resident, Medicine, State University of New York - Buffalo, 1977 - 1980
  • Intern, Medicine, State University of New York - Buffalo, 1977 - 1978
  • M.D., New York University, 1977

Publications

Xu, Julia Z., Wilaslak Tanongsaksakul, Thidarat Suksangpleng, Supachai Ekwattanakit, Suchada Riolueang, Marilyn J. Telen, and Vip Viprakasit. “Feasibility of and barriers to thalassemia screening in migrant populations: a cross-sectional study of Myanmar and Cambodian migrants in Thailand.” Bmc Public Health 21, no. 1 (June 21, 2021): 1177. https://doi.org/10.1186/s12889-021-11059-2.

PMID
34154562
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Ataga, Kenneth I., Qingning Zhou, Vimal K. Derebail, Santosh L. Saraf, Jane S. Hankins, Laura R. Loehr, Melanie E. Garrett, Allison E. Ashley-Koch, Jianwen Cai, and Marilyn J. Telen. “Rapid decline in estimated glomerular filtration rate in sickle cell anemia: results of a multicenter pooled analysis.” Haematologica 106, no. 6 (June 1, 2021): 1749–53. https://doi.org/10.3324/haematol.2020.267419.

PMID
33179474
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Natarajan, Pradeep, Akhil Pampana, Sarah E. Graham, Sanni E. Ruotsalainen, James A. Perry, Paul S. de Vries, Jai G. Broome, et al. “Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices.” Nat Commun 12, no. 1 (April 12, 2021): 2182. https://doi.org/10.1038/s41467-021-22339-1.

PMID
33846329
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Brown, R Clark, Kimberly Cruz, Theodosia A. Kalfa, Frans A. Kuypers, Santosh L. Saraf, Jeremie H. Estepp, Luke R. Smart, et al. “FT-4202, an allosteric activator of pyruvate kinase-R, demonstrates proof of mechanism and proof of concept after multiple daily doses in a phase 1 study of patients with sickle cell disease.” In British Journal of Haematology, 193:23–24, 2021.

Scholars@Duke

Bick, Alexander G., Joshua S. Weinstock, Satish K. Nandakumar, Charles P. Fulco, Erik L. Bao, Seyedeh M. Zekavat, Mindy D. Szeto, et al. “Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes.” Nature 591, no. 7851 (March 2021): E27. https://doi.org/10.1038/s41586-021-03280-1.

PMID
33707633
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Ilboudo, Yann, Melanie E. Garrett, Pablo Bartolucci, Carlo Brugnara, Clary B. Clish, Joel N. Hirschhorn, Frédéric Galactéros, Allison E. Ashley-Koch, Marilyn J. Telen, and Guillaume Lettre. “Potential causal role of l-glutamine in sickle cell disease painful crises: A Mendelian randomization analysis.” Blood Cells Mol Dis 86 (February 2021): 102504. https://doi.org/10.1016/j.bcmd.2020.102504.

PMID
32949984
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Dinardo, Carla L., Theo G. M. Oliveira, Shannon Kelly, Allison Ashley-Koch, Marilyn Telen, Luciana C. Schmidt, Shirley Castilho, et al. “Diversity of variant alleles encoding Kidd, Duffy, and Kell antigens in individuals with sickle cell disease using whole genome sequencing data from the NHLBI TOPMed Program.” Transfusion 61, no. 2 (February 2021): 603–16. https://doi.org/10.1111/trf.16204.

PMID
33231305
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Taliun, Daniel, Daniel N. Harris, Michael D. Kessler, Jedidiah Carlson, Zachary A. Szpiech, Raul Torres, Sarah A Gagliano Taliun, et al. “Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program.” Nature 590, no. 7845 (February 2021): 290–99. https://doi.org/10.1038/s41586-021-03205-y.

PMID
33568819
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Nielsen, Jonas B., Oren Rom, Ida Surakka, Sarah E. Graham, Wei Zhou, Tanmoy Roychowdhury, Lars G. Fritsche, et al. “Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease.” Nat Commun 11, no. 1 (December 18, 2020): 6417. https://doi.org/10.1038/s41467-020-20086-3.

PMID
33339817
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Wen, Fayuan, Angela Rock, Juan Salomon-Andonie, Gulriz Kurban, Xiaomei Niu, Songping Wang, Xu Zhang, et al. “Genome Wide Association Analysis of Iron Overload in the Trans-Omics for Precision Medicine (TOPMed) Sickle Cell Disease Cohorts.” In Blood, 136:52–52. American Society of Hematology, 2020. https://doi.org/10.1182/blood-2020-142809.

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