Marilyn Jo Telen, MD

Professor of Medicine
Wellcome Clinical Distinguished Professor of Medicine in Honor of R. Wayne Rundles, M.D.
Associate Professor of Pathology
Member of the Duke Cancer Institute
Affiliate, Duke Global Health Institute
Campus mail 333 Med Sci Res Bldg, Durham, NC 27710
Phone (919) 684-5378
Email address marilyn.telen@duke.edu

Dr. Telen is recognized as an expert in the biochemistry and molecular genetics of blood group antigens and the pathophysiological mechanisms of vaso-occlusion in sickle cell disease. She is the Director of the Duke Comprehensive Sickle Cell Center.

Dr. Telen's laboratory focuses on structure/function analysis of membrane proteins expressed by erythroid cells, as well as the role of these proteins in non-erythroid cells. Proteins are also studied in transfectant systems, and research focuses especially on adhesion receptors. The goals of this work are (1) to understand the mechanism and role of red cell adhesion to leukocytes and endothelium in sickle cell disease; (2) to understand the signaling mechanisms leading to activation (and inactivation) of red cell adhesion molecules; (3) to understand the molecular basis of blood group antigen expression, and (4) to understand the interactions of erythroid membrane proteins with other cells and with extracellular matrix..

Recent investigations have focused on the role of signaling pathways in the upregulation of sickle red cell adhesion. Present studies include (1) investigation of beta-adrenergic signaling pathway responsible for activation of B-CAM/LU and LW adhesion receptors; (2) understanding how nitric oxide and ATP downregulate sickle red cell adhesion; (3) studying the effect of these processes in animal models.

Dr. Telen is also involved in a large multicenter study looking for genetic polymorphisms that affect clinical outcomes in sickle cell disease, as well as a multi-center study investigating the mechanisms and treatment of pulmonary hypertension in sickle cell disease.

Key Words:

Adhesion molecules
Erythrocyte membrane
Sickle cell disease
Transfusion medicine
Immunohematology
CD44
B-CAM/LU
Genetic polymorphisms

Education and Training

  • Fellowship, Hematology/ Oncology, Duke University School of Medicine, 1980 - 1983
  • Resident, Medicine, State University of New York - Buffalo, 1977 - 1980
  • Intern, Medicine, State University of New York - Buffalo, 1977 - 1978
  • M.D., New York University, 1977

Publications

Ataga, Kenneth I., Qingning Zhou, Santosh L. Saraf, Jane S. Hankins, Emily J. Ciccone, Laura R. Loehr, Allison E. Ashley-Koch, et al. “Longitudinal Study of Glomerular Hyperfiltration in Adults with Sickle Cell Anemia: A Multicenter Pooled Analysis.” Blood Adv, June 13, 2022. https://doi.org/10.1182/bloodadvances.2022007693.

PMID
35696734
Full Text

Kalfa, Theodosia A., Marilyn J. Telen, Santosh L. Saraf, R Clark Brown, Katie Giger Seu, Sandra K. Larkin, Eric Soupene, et al. “Etavopivat, an investigational, once-daily, selective pyruvate kinase-R activator, improves sickle red blood cell health and survival in patients with sickle cell disease: an analysis of exploratory studies in a phase 1 trial.” In British Journal of Haematology, 197:12–13, 2022.

Scholars@Duke

Liggett, L Alexander, Liam D. Cato, Joshua S. Weinstock, Yingze Zhang, S Mehdi Nouraie, Mark T. Gladwin, Melanie E. Garrett, et al. “Clonal hematopoiesis in sickle cell disease.” J Clin Invest 132, no. 4 (February 15, 2022). https://doi.org/10.1172/JCI156060.

PMID
34990411
Full Text

Taub, Margaret A., Matthew P. Conomos, Rebecca Keener, Kruthika R. Iyer, Joshua S. Weinstock, Lisa R. Yanek, John Lane, et al. “Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed.” Cell Genom 2, no. 1 (January 12, 2022). https://doi.org/10.1016/j.xgen.2021.100084.

PMID
35530816
Full Text

Luo, Yang, Masahiro Kanai, Wanson Choi, Xinyi Li, Saori Sakaue, Kenichi Yamamoto, Kotaro Ogawa, et al. “Author Correction: A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.” Nat Genet 53, no. 12 (December 2021): 1722. https://doi.org/10.1038/s41588-021-00979-9.

PMID
34728834
Full Text

Xu, Julia Z., Meghan Foe, Wilaslak Tanongsaksakul, Thidarat Suksangpleng, Supachai Ekwattanakit, Suchada Riolueang, Marilyn J. Telen, Bonnie N. Kaiser, and Vip Viprakasit. “Identification of optimal thalassemia screening strategies for migrant populations in Thailand using a qualitative approach.” Bmc Public Health 21, no. 1 (October 6, 2021): 1796. https://doi.org/10.1186/s12889-021-11831-4.

PMID
34615515
Full Text

Luo, Yang, Masahiro Kanai, Wanson Choi, Xinyi Li, Saori Sakaue, Kenichi Yamamoto, Kotaro Ogawa, et al. “A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.” Nat Genet 53, no. 10 (October 2021): 1504–16. https://doi.org/10.1038/s41588-021-00935-7.

PMID
34611364
Full Text

Cade, Brian E., Jiwon Lee, Tamar Sofer, Heming Wang, Man Zhang, Han Chen, Sina A. Gharib, et al. “Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.” Genome Med 13, no. 1 (August 26, 2021): 136. https://doi.org/10.1186/s13073-021-00917-8.

PMID
34446064
Full Text

Xu, Julia Z., Wilaslak Tanongsaksakul, Thidarat Suksangpleng, Supachai Ekwattanakit, Suchada Riolueang, Marilyn J. Telen, and Vip Viprakasit. “Feasibility of and barriers to thalassemia screening in migrant populations: a cross-sectional study of Myanmar and Cambodian migrants in Thailand.” Bmc Public Health 21, no. 1 (June 21, 2021): 1177. https://doi.org/10.1186/s12889-021-11059-2.

PMID
34154562
Full Text

Keramati, Ali R., Ming-Huei Chen, Benjamin A. T. Rodriguez, Lisa R. Yanek, Arunoday Bhan, Brady J. Gaynor, Kathleen Ryan, et al. “Genome sequencing unveils a regulatory landscape of platelet reactivity.” Nat Commun 12, no. 1 (June 15, 2021): 3626. https://doi.org/10.1038/s41467-021-23470-9.

PMID
34131117
Full Text

Pages