Dr. Telen is recognized as an expert in the biochemistry and molecular genetics of blood group antigens and the pathophysiological mechanisms of vaso-occlusion in sickle cell disease. She is the Director of the Duke Comprehensive Sickle Cell Center.
Dr. Telen's laboratory focuses on structure/function analysis of membrane proteins expressed by erythroid cells, as well as the role of these proteins in non-erythroid cells. Proteins are also studied in transfectant systems, and research focuses especially on adhesion receptors. The goals of this work are (1) to understand the mechanism and role of red cell adhesion to leukocytes and endothelium in sickle cell disease; (2) to understand the signaling mechanisms leading to activation (and inactivation) of red cell adhesion molecules; (3) to understand the molecular basis of blood group antigen expression, and (4) to understand the interactions of erythroid membrane proteins with other cells and with extracellular matrix..
Recent investigations have focused on the role of signaling pathways in the upregulation of sickle red cell adhesion. Present studies include (1) investigation of beta-adrenergic signaling pathway responsible for activation of B-CAM/LU and LW adhesion receptors; (2) understanding how nitric oxide and ATP downregulate sickle red cell adhesion; (3) studying the effect of these processes in animal models.
Dr. Telen is also involved in a large multicenter study looking for genetic polymorphisms that affect clinical outcomes in sickle cell disease, as well as a multi-center study investigating the mechanisms and treatment of pulmonary hypertension in sickle cell disease.
Sickle cell disease
Education and Training
- Fellowship, Hematology/ Oncology, Duke University School of Medicine, 1980 - 1983
- Resident, Medicine, State University of New York at Buffalo, 1977 - 1980
- Intern, Medicine, State University of New York at Buffalo, 1977 - 1978
- M.D., New York University, 1977
- Randomized double-blind study of FT-4202 in sickle cell disease
- Duke CTSA (TL1)
- Transfusion Medicine and Hematology
- Role of RBC Reactive Oxygen Species and Their Vicious Cycle in Sickle Vasculopathy
- Multi-site Clinical Laboratory Testing for SickleScan
- Patient Preference Information: Bridging Regulatory Decisions and Clinical Practice
- AN OPEN-LABEL EXTENSION STUDY TO EVALUATE THE SAFETY OF RIVIPANSEL (GMI-1070) IN THE TREATMENT OF ONE OR MORE VASOOCCLUSIVE CRISES IN HOSPITALIZED SUBJECTS WITH SICKLE CELL DISEASE.
- CSA - Pfizer 212511 B5201002 Phase 3 Randomized Multicenter Trial
- Sharing Comprehensive 'Omics in Sickle Cell Disease Through the NHLBI TOPMed Network
- Transcriptomic, therapeutic and genetic investigations of sickle cell nephropathy
- FORMA Therapeutics FT-4202
- High-throughput Metabolite Profiling and Genetic Analyses