Marilyn Jo Telen, MD

Professor of Medicine
Wellcome Clinical Professor of Medicine in Honor of R. Wayne Rundles, M.D., in the School of Medicine
Associate Professor of Pathology
Member of the Duke Cancer Institute
Affiliate, Duke Global Health Institute
Campus mail 333 Med Sci Res Bldg, Durham, NC 27710
Phone (919) 684-5378
Email address marilyn.telen@duke.edu

Dr. Telen is recognized as an expert in the biochemistry and molecular genetics of blood group antigens and the pathophysiological mechanisms of vaso-occlusion in sickle cell disease. She is the Director of the Duke Comprehensive Sickle Cell Center.

Dr. Telen's laboratory focuses on structure/function analysis of membrane proteins expressed by erythroid cells, as well as the role of these proteins in non-erythroid cells. Proteins are also studied in transfectant systems, and research focuses especially on adhesion receptors. The goals of this work are (1) to understand the mechanism and role of red cell adhesion to leukocytes and endothelium in sickle cell disease; (2) to understand the signaling mechanisms leading to activation (and inactivation) of red cell adhesion molecules; (3) to understand the molecular basis of blood group antigen expression, and (4) to understand the interactions of erythroid membrane proteins with other cells and with extracellular matrix..

Recent investigations have focused on the role of signaling pathways in the upregulation of sickle red cell adhesion. Present studies include (1) investigation of beta-adrenergic signaling pathway responsible for activation of B-CAM/LU and LW adhesion receptors; (2) understanding how nitric oxide and ATP downregulate sickle red cell adhesion; (3) studying the effect of these processes in animal models.

Dr. Telen is also involved in a large multicenter study looking for genetic polymorphisms that affect clinical outcomes in sickle cell disease, as well as a multi-center study investigating the mechanisms and treatment of pulmonary hypertension in sickle cell disease.

Key Words:

Adhesion molecules
Erythrocyte membrane
Sickle cell disease
Transfusion medicine
Immunohematology
CD44
B-CAM/LU
Genetic polymorphisms

Education and Training

  • Fellowship, Hematology/ Oncology, Duke University School of Medicine, 1980 - 1983
  • Resident, Medicine, State University of New York at Buffalo, 1977 - 1980
  • Intern, Medicine, State University of New York at Buffalo, 1977 - 1978
  • M.D., New York University, 1977

Publications

Ilboudo, Y, Bartolucci, P, Garrett, ME, Ashley-Koch, A, Telen, M, Brugnara, C, Galactéros, F, and Lettre, G. "A common functional PIEZO1 deletion allele associates with red blood cell density in sickle cell disease patients." American Journal of Hematology 93, no. 11 (November 2018): E362-E365. (Letter)

PMID
30105803
Full Text

Xu, JZ, Garrett, ME, Soldano, KL, Chen, ST, Clish, CB, Ashley-Koch, AE, and Telen, MJ. "Clinical and metabolomic risk factors associated with rapid renal function decline in sickle cell disease." American Journal of Hematology (August 24, 2018).

PMID
30144150
Full Text

Zekavat, SM, Ruotsalainen, S, Handsaker, RE, Alver, M, Bloom, J, Poterba, T, Seed, C, Ernst, J, Chaffin, M, Engreitz, J, Peloso, GM, Manichaikul, A, Yang, C, Ryan, KA, Fu, M, Johnson, WC, Tsai, M, Budoff, M, Vasan, RS, Cupples, LA, Rotter, JI, Rich, SS, Post, W, Mitchell, BD, Correa, A, Metspalu, A, Wilson, JG, Salomaa, V, Kellis, M, Daly, MJ, Neale, BM, McCarroll, S, Surakka, I, Esko, T, Ganna, A, Ripatti, S, Kathiresan, S, Natarajan, P, and NHLBI TOPMed Lipids Working Group, . "Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries." Nature Communications 9, no. 1 (August 23, 2018): 3493-null.

PMID
30140049
Full Text

Natarajan, P, Peloso, GM, Zekavat, SM, Montasser, M, Ganna, A, Chaffin, M, Khera, AV, Zhou, W, Bloom, JM, Engreitz, JM, Ernst, J, O'Connell, JR, Ruotsalainen, SE, Alver, M, Manichaikul, A, Johnson, WC, Perry, JA, Poterba, T, Seed, C, Surakka, IL, Esko, T, Ripatti, S, Salomaa, V, Correa, A, Vasan, RS, Kellis, M, Neale, BM, Lander, ES, Abecasis, G, Mitchell, B, Rich, SS, Wilson, JG, Cupples, LA, Rotter, JI, Willer, CJ, Kathiresan, S, and NHLBI TOPMed Lipids Working Group, . "Deep-coverage whole genome sequences and blood lipids among 16,324 individuals." Nature Communications 9, no. 1 (August 23, 2018): 3391-null.

PMID
30140000
Full Text

Zekavat, SM, Ruotsalainen, S, Handsaker, RE, Alver, M, Bloom, J, Poterba, T, Seed, C, Ernst, J, Chaffin, M, Engreitz, J, Peloso, GM, Manichaikul, A, Yang, C, Ryan, KA, Fu, M, Johnson, WC, Tsai, M, Budoff, M, Vasan, RS, Cupples, LA, Rotter, JI, Rich, SS, Post, W, Mitchell, BD, Correa, A, Metspalu, A, Wilson, JG, Salomaa, V, Kellis, M, Daly, MJ, Neale, BM, McCarroll, S, Surakka, I, Esko, T, Ganna, A, Ripatti, S, Kathiresan, S, Natarajan, P, and NHLBI TOPMed Lipids Working Group, . "Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries." Nature Communications 9, no. 1 (July 4, 2018): 2606-null.

PMID
29973585
Full Text

Bundy, JL, Anderson, BR, Francescatto, L, Garrett, ME, Soldano, KL, Telen, MJ, Davis, EE, and Ashley-Koch, AE. "RNA-Sequencing of Isolated Cell Populations Expressing Human APOL1 Risk Variants Reveals Molecular Correlates of Sickle Cell Nephropathy in Zebrafish Podocytes." 59th Annual Meeting of the American-Society-of-Hematology (ASH). Atlanta, GA. December 9, 2017 - December 12, 2017.: AMER SOC HEMATOLOGY, December 7, 2017.

Scholars@Duke

Adam, SS, Flahiff, CM, Kamble, S, Telen, MJ, Reed, SD, and De Castro, LM. "Depression, quality of life, and medical resource utilization in sickle cell disease." Blood Advances 1, no. 23 (October 12, 2017): 1983-1992.

PMID
29296845
Full Text

Jacob, SA, Novelli, EM, Isenberg, JS, Garrett, ME, Chu, Y, Soldano, K, Ataga, KI, Telen, MJ, Ashley-Koch, A, Gladwin, MT, Zhang, Y, and Kato, GJ. "Thrombospondin-1 gene polymorphism is associated with estimated pulmonary artery pressure in patients with sickle cell anemia." American journal of hematology 92, no. 3 (March 2017): E31-E34. (Letter)

PMID
28033687
Full Text

Telen, MJ. "Developing new pharmacotherapeutic approaches to treating sickle-cell disease." ISBT science series 12, no. 1 (February 2017): 239-247.

PMID
28484512
Full Text

Jacob, SA, Novelli, EM, Isenberg, JS, Garrett, ME, Chu, Y, Soldano, KL, Ataga, KI, Telen, MJ, Ashley-Koch, AE, Zhang, Y, and Kato, GJ. "Thrombospondin-1 Polymorphisms Are Associated with Chronic Kidney Disease in Sickle Cell Anemia." December 2, 2016.

Scholars@Duke

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