Matthew A. Sparks, MD

Assistant Professor of Medicine
Campus mail 2 Genome Court, Msrb2 Room 1013, Box_103015, Durham, NC 27710
Phone (919) 684-9737
Email address matthew.sparks@duke.edu

My lab is interested in understanding how both the renin angiotensin and prostanoid systems regulate blood pressure by altering blood flow to the kidney. My lab utilizes a combination of physiologic and molecular techniques in genetically modified mice to probe questions about how changes in the micro circulation in the kidney alter sodium excretion. The overarching goal of this research is to identify novel mechanisms to target drug therapy for patients with hypertension. My research is funded by a career development award from the Department of Veterans Affairs Office of Research and Development (IK2BX002240) and a Scientist Development Grant from the American Heart Association. In my role as Director of Undergraduate Medical Research in the Department of Medicine I help promote research in the Department of Medicine during the 3rd year of medical school at Duke University. I also serve as the Associate Program Director for the Nephrology Fellowship Program.

I'm also interested finding ways to promote medical education. My focus is on leveraging social media to enhance learning in nephrology. I am a faculty member of the Nephrology Social Media Collective (NSMC) and member of the online nephrology journal club (NephJC). I am also co-founder and advisory board member of the first nephrology blog associated with a journal- AJKD blog, the official blog of the American Journal of Kidney Diseases. Co-creator of the popular edutainment project NephMadness. Past deputy editor of Renal Fellow Network where I continue to remain an advocate for the site and author the yearly “Top Nephrology Stories of the Year”. I am currently a member of the Communications and Media Committee of the American Society of Nephrology, the American Heart Association and am a fellow of the American Society of Nephrology and the National Kidney Foundation.

I serve as Education Director for KIDNEYcon- a yearly hands-on conference dedicated to advances in nephrology held in Little Rock, AR each April.

@Nephro_Sparks on Twitter

Nephrology Fellowship Program

Education and Training

  • Fellow in Nephrology, Medicine, Duke University School of Medicine, 2007 - 2011
  • Chief Resident, Medicine, University of Arkansas for Medical Sciences College of Medicine, 2006 - 2007
  • Resident, Medicine, University of Arkansas for Medical Sciences College of Medicine, 2003 - 2006
  • M.D., University of Arkansas for Medical Sciences College of Medicine, 2003

Publications

Wolf, E, Kothari, NR, Roberts, JK, and Sparks, MA. "Baclofen Toxicity in Kidney Disease." American journal of kidney diseases : the official journal of the National Kidney Foundation (September 9, 2017).

PMID
28899601
Full Text

Wang, L, Sha, Y, Bai, J, Eisner, W, Sparks, MA, Buckley, AF, and Spurney, RF. "Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease." American journal of physiology. Renal physiology 313, no. 2 (August 2017): F430-F439.

PMID
28490532
Full Text

Topf, JM, Sparks, MA, Phelan, PJ, Shah, N, Lerma, EV, Graham-Brown, MPM, Madariaga, H, Iannuzzella, F, Rheault, MN, Oates, T, Jhaveri, KD, and Hiremath, S. "The Evolution of the Journal Club: From Osler to Twitter." American journal of kidney diseases : the official journal of the National Kidney Foundation 69, no. 6 (June 2017): 827-836. (Review)

PMID
28233653
Full Text

Stegbauer, J, Chen, D, Herrera, M, Sparks, MA, Yang, T, Königshausen, E, Gurley, SB, and Coffman, TM. "Resistance to hypertension mediated by intercalated cells of the collecting duct." JCI insight 2, no. 7 (April 6, 2017): e92720-.

PMID
28405625
Full Text

Roberts, JK, Sparks, MA, and Lehrich, RW. "Medical student attitudes toward kidney physiology and nephrology: a qualitative study." Renal failure 38, no. 10 (November 2016): 1683-1693.

PMID
27758129
Full Text

Zhang, J, Rudemiller, NP, Patel, MB, Wei, Q, Karlovich, NS, Jeffs, AD, Wu, M, Sparks, MA, Privratsky, JR, Herrera, M, Gurley, SB, Nedospasov, SA, and Crowley, SD. "Competing Actions of Type 1 Angiotensin II Receptors Expressed on T Lymphocytes and Kidney Epithelium during Cisplatin-Induced AKI." Journal of the American Society of Nephrology : JASN 27, no. 8 (August 2016): 2257-2264.

PMID
26744488
Full Text

Cameron, CB, Nair, V, Varma, M, Adams, M, Jhaveri, KD, and Sparks, MA. "Does Academic Blogging Enhance Promotion and Tenure? A Survey of US and Canadian Medicine and Pediatric Department Chairs." JMIR medical education 2, no. 1 (June 23, 2016): e10-.

PMID
27731858
Scholars@Duke

Chen, D, Stegbauer, J, Sparks, MA, Kohan, D, Griffiths, R, Herrera, M, Gurley, SB, and Coffman, TM. "Impact of Angiotensin Type 1A Receptors in Principal Cells of the Collecting Duct on Blood Pressure and Hypertension." Hypertension (Dallas, Tex. : 1979) 67, no. 6 (June 2016): 1291-1297.

PMID
27141055
Full Text

Zhang, J, Rudemiller, NP, Patel, MB, Karlovich, NS, Wu, M, McDonough, AA, Griffiths, R, Sparks, MA, Jeffs, AD, and Crowley, SD. "Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron." Cell metabolism 23, no. 2 (February 2016): 360-368.

PMID
26712462
Full Text

Sparks, MA, Stegbauer, J, Chen, D, Gomez, JA, Griffiths, RC, Azad, HA, Herrera, M, Gurley, SB, and Coffman, TM. "Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion." Journal of the American Society of Nephrology : JASN 26, no. 12 (December 2015): 2953-2962.

PMID
25855778
Full Text

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