Matthew A. Sparks, MD

Assistant Professor of Medicine
Campus mail 2 Genome Court, Msrb2 Room 1013, Box 103015, Durham, NC 27710
Phone (919) 684-9737
Email address matthew.sparks@duke.edu

My lab is interested in understanding how both the renin angiotensin and prostanoid systems regulate blood pressure by altering blood flow to the kidney. My lab utilizes a combination of physiologic and molecular techniques in genetically modified mice to probe questions about how changes in the micro circulation in the kidney alter sodium excretion. The overarching goal of this research is to identify novel mechanisms to target drug therapy for patients with hypertension. My research has been funded by the Department of Veterans Affairs Office of Research and Development and the American Heart Association. In my role as Director of Medical Student Research in the Department of Medicine I help promote research in the Department of Medicine during the 3rd year of medical school at Duke University. I serve as the Associate Program Director for the Nephrology Fellowship Program.

I'm also interested finding ways to promote medical education. My focus is on leveraging social media to enhance learning in nephrology. I am a faculty member of the Nephrology Social Media Collective (NSMC) and member of the board of directors of nephrology journal club (NephJC), a non-profit organization dedicated to enhancing free online medical education in nephrology. I am also co-founder and advisory board member of the first nephrology blog associated with a journal- AJKD blog, the official blog of the American Journal of Kidney Diseases. Co-creator of the popular educational project NephMadness. Past deputy editor of Renal Fellow Network where I continue to remain as faculty lead. I am currently a member of the Communications and Media Committee of the American Society of Nephrology, the American Heart Association and am a fellow of the American Society of Nephrology, the American Heart Association, and the National Kidney Foundation.

I serve as Education Director for KIDNEYcon- a yearly hands-on conference dedicated to advances in nephrology held in Little Rock, AR each April.

@Nephro_Sparks on Twitter

Nephrology Fellowship Program

Education and Training

  • Fellow in Nephrology, Medicine, Duke University School of Medicine, 2007 - 2011
  • Chief Resident, Medicine, University of Arkansas for Medical Sciences College of Medicine, 2006 - 2007
  • Resident, Medicine, University of Arkansas for Medical Sciences College of Medicine, 2003 - 2006
  • M.D., University of Arkansas for Medical Sciences College of Medicine, 2003

Publications

Sparks, Matthew A., Andrew South, Paul Welling, J Matt Luther, Jordana Cohen, James Brian Byrd, Louise M. Burrell, et al. “Sound Science before Quick Judgement Regarding RAS Blockade in COVID-19.” Clin J Am Soc Nephrol, March 27, 2020. https://doi.org/10.2215/CJN.03530320.

PMID
32220930
Full Text

Farouk, Samira, and Matthew A. Sparks. “Editorial commentary: The public physician in cardiology: The solution to information pollution.” Trends Cardiovasc Med 30, no. 1 (January 2020): 36–38. https://doi.org/10.1016/j.tcm.2019.02.002.

PMID
30797695
Full Text

Lu, Xiaohan, Nathan P. Rudemiller, Yi Wen, Jiafa Ren, Gianna E. Hammer, Robert Griffiths, Jamie R. Privratsky, Bo Yang, Matthew A. Sparks, and Steven D. Crowley. “A20 in Myeloid Cells Protects Against Hypertension by Inhibiting Dendritic Cell-Mediated T-Cell Activation.” Circ Res 125, no. 12 (December 6, 2019): 1055–66. https://doi.org/10.1161/CIRCRESAHA.119.315343.

PMID
31630621
Full Text

Edmonston, Daniel L., Kishan S. Parikh, Sudarshan Rajagopal, Linda K. Shaw, Dennis Abraham, Alexander Grabner, Matthew A. Sparks, and Myles Wolf. “Pulmonary Hypertension Subtypes and Mortality in CKD.” Am J Kidney Dis, November 12, 2019. https://doi.org/10.1053/j.ajkd.2019.08.027.

PMID
31732231
Full Text

Prince, Lisa K., Robert Nee, Christina M. Yuan, and Christina M. Nephrology Education Research and Development Consortium (NERDC). “The Acute Dialysis Orders Objective Structured Clinical Examination (OSCE): Fellow Performance on a Formative Assessment of Acute Kidney Replacement Therapy Competence.” Clin J Am Soc Nephrol 14, no. 9 (September 6, 2019): 1346–54. https://doi.org/10.2215/CJN.02900319.

PMID
31409597
Full Text

Provenzano, Anthony M., and Matthew A. Sparks. “The renin-angiotensin-aldosterone system update: full-court press.” Nephrol Dial Transplant, July 11, 2019. https://doi.org/10.1093/ndt/gfz123.

PMID
31665432
Full Text

Panigrahy, Dipak, Allison Gartung, Jun Yang, Haixia Yang, Molly M. Gilligan, Megan L. Sulciner, Swati S. Bhasin, et al. “Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases.” J Clin Invest 129, no. 7 (June 17, 2019): 2964–79. https://doi.org/10.1172/JCI127282.

PMID
31205032
Full Text

Shah, Roopa, and Matthew A. Sparks. “Renin-angiotensin system inhibition in advanced chronic kidney disease: how low can the kidney function go?” Current Opinion in Nephrology and Hypertension 28, no. 2 (March 2019): 171–77. https://doi.org/10.1097/mnh.0000000000000484.

PMID
30585852
Full Text

Herrera, Marcela, Ting Yang, Matthew A. Sparks, Michael W. Manning, Beverly H. Koller, and Thomas M. Coffman. “Complex Role for E-Prostanoid 4 Receptors in Hypertension.” J Am Heart Assoc 8, no. 4 (February 19, 2019): e010745. https://doi.org/10.1161/JAHA.118.010745.

PMID
30764697
Full Text

Pages