Matthew A. Sparks, MD

Assistant Professor of Medicine
Campus mail 2 Genome Court, Msrb2 Room 1013, Box 103015, Durham, NC 27710
Phone (919) 684-9737
Email address matthew.sparks@duke.edu

My lab is interested in understanding how both the renin angiotensin and prostanoid systems regulate blood pressure by altering blood flow to the kidney. My lab utilizes a combination of physiologic and molecular techniques in genetically modified mice to probe questions about how changes in the micro circulation in the kidney alter sodium excretion. The overarching goal of this research is to identify novel mechanisms to target drug therapy for patients with hypertension. My research has been funded by the Department of Veterans Affairs Office of Research and Development and the American Heart Association. In my role as Director of Medical Student Research in the Department of Medicine I help promote research in the Department of Medicine during the 3rd year of medical school at Duke University. I serve as the Associate Program Director for the Nephrology Fellowship Program.

I'm also interested finding ways to promote medical education. My focus is on leveraging social media to enhance learning in nephrology. I am a faculty member of the Nephrology Social Media Collective (NSMC) and member of the board of directors of nephrology journal club (NephJC), a non-profit organization dedicated to enhancing free online medical education in nephrology. I am also co-founder and advisory board member of the first nephrology blog associated with a journal- AJKD blog, the official blog of the American Journal of Kidney Diseases. Co-creator of the popular educational project NephMadness. Past deputy editor of Renal Fellow Network where I continue to remain as faculty lead. I am currently a member of the Communications and Media Committee of the American Society of Nephrology, the American Heart Association and am a fellow of the American Society of Nephrology, the American Heart Association, and the National Kidney Foundation.

I serve as Education Director for KIDNEYcon- a yearly hands-on conference dedicated to advances in nephrology held in Little Rock, AR each April.

@Nephro_Sparks on Twitter

Nephrology Fellowship Program

Education and Training

  • Fellow in Nephrology, Medicine, Duke University School of Medicine, 2007 - 2011
  • Chief Resident, Medicine, University of Arkansas for Medical Sciences, College of Medicine, 2006 - 2007
  • Resident, Medicine, University of Arkansas for Medical Sciences, College of Medicine, 2003 - 2006
  • M.D., University of Arkansas for Medical Sciences, College of Medicine, 2003

Publications

Batlle, Daniel, Maria Jose Soler, Matthew A. Sparks, Swapnil Hiremath, Andrew M. South, Paul A. Welling, Sundararaman Swaminathan, and Sundararaman COVID-19 and ACE2 in Cardiovascular, Lung, and Kidney Working Group. “Acute Kidney Injury in COVID-19: Emerging Evidence of a Distinct Pathophysiology.” J Am Soc Nephrol 31, no. 7 (July 2020): 1380–83. https://doi.org/10.1681/ASN.2020040419.

PMID
32366514
Full Text

Cohen, Jordana B., Thomas C. Hanff, Andrew M. South, Matthew A. Sparks, Swapnil Hiremath, Adam P. Bress, J Brian Byrd, and Julio A. Chirinos. “Response by Cohen et al to Letter Regarding Article, "Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19".” Circ Res 126, no. 12 (June 5, 2020): e140–41. https://doi.org/10.1161/CIRCRESAHA.120.317205.

PMID
32496917
Full Text

South, Andrew M., Laurie Tomlinson, Daniel Edmonston, Swapnil Hiremath, and Matthew A. Sparks. “Controversies of renin-angiotensin system inhibition during the COVID-19 pandemic.” Nat Rev Nephrol 16, no. 6 (June 2020): 305–7. https://doi.org/10.1038/s41581-020-0279-4.

PMID
32246101
Full Text

Sparks, Matthew A., Andrew South, Paul Welling, J Matt Luther, Jordana Cohen, James Brian Byrd, Louise M. Burrell, et al. “Sound Science before Quick Judgement Regarding RAS Blockade in COVID-19.” Clin J Am Soc Nephrol 15, no. 5 (May 7, 2020): 714–16. https://doi.org/10.2215/CJN.03530320.

PMID
32220930
Full Text

Welling, Paul A., Daniel Batlle, James Brian Byrd, Louise M. Burrell, Andrew M. South, and Matthew A. Sparks. “Rigor before speculation in COVID-19 therapy.” Am J Physiol Lung Cell Mol Physiol 318, no. 5 (May 1, 2020): L1027–28. https://doi.org/10.1152/ajplung.00152.2020.

PMID
32364442
Full Text

Edmonston, Daniel L., Kishan S. Parikh, Sudarshan Rajagopal, Linda K. Shaw, Dennis Abraham, Alexander Grabner, Matthew A. Sparks, and Myles Wolf. “Pulmonary Hypertension Subtypes and Mortality in CKD.” Am J Kidney Dis 75, no. 5 (May 2020): 713–24. https://doi.org/10.1053/j.ajkd.2019.08.027.

PMID
31732231
Full Text

Tignanelli, Christopher J., Nicholas E. Ingraham, Matthew A. Sparks, Ronald Reilkoff, Tamara Bezdicek, Bradley Benson, Timothy Schacker, Jeffrey G. Chipman, and Michael A. Puskarich. “Antihypertensive drugs and risk of COVID-19?” Lancet Respir Med 8, no. 5 (May 2020): e30–31. https://doi.org/10.1016/S2213-2600(20)30153-3.

PMID
32222166
Full Text

Ingraham, Nicholas E., David Boulware, Matthew A. Sparks, Timothy Schacker, Bradley Benson, Jeffrey A. Sparks, Thomas Murray, et al. “Shining a light on the evidence for hydroxychloroquine in SARS-CoV-2.” Crit Care 24, no. 1 (April 28, 2020): 182. https://doi.org/10.1186/s13054-020-02894-7.

PMID
32345336
Full Text

Pages