Matthew A. Sparks, MD

Assistant Professor of Medicine
Campus mail 2 Genome Court, Msrb2 Room 1013, Box 103015, Durham, NC 27710
Phone (919) 684-9737
Email address matthew.sparks@duke.edu

I serve as the Associate Program Director for the Nephrology Fellowship Program. My goal is to work with each fellow to ensure they develop a successful career in whatever direction they choose. In my role as Director of Medical Student Research in the Department of Medicine I help promote research in the Department of Medicine during the 3rd year of medical school at Duke University.

Nephrology Fellowship Program

My laboratory is interested in understanding how both the renin angiotensin and prostanoid systems regulate blood pressure by altering blood flow to the kidney. We use a combination of physiologic and molecular techniques in genetically modified mice to probe questions about how changes in the micro circulation in the kidney alter sodium excretion. The overarching goal of this research is to identify novel mechanisms to target drug therapy for patients with hypertension. My research has been funded by the Department of Veterans Affairs Office of Research and Development and the American Heart Association. We also explore the link between pulmonary hypertension and CKD. Recently, we are investigating the link between SARS-CoV-2 and the Renin Angiotensin System.

Sparks Laboratory Website

I'm also interested finding ways to promote medical education. My focus is on leveraging social media to enhance learning in nephrology. I serve as the co-program director of the Nephrology Social Media Collective (NSMC) and member of the board of directors of nephrology journal club (NephJC), a non-profit organization dedicated to enhancing free online medical education in nephrology. I am also co-founder and advisory board member of the first nephrology blog associated with a journal- AJKD blog, the official blog of the American Journal of Kidney Diseases. Co-creator of the popular educational project NephMadness. Past deputy editor of Renal Fellow Network where I continue to remain as faculty lead. I am currently a member of the Communications and Media Committee of the American Society of Nephrology, the American Heart Association and am a fellow of the American Society of Nephrology, the American Heart Association, and the National Kidney Foundation.

I serve as Education Director for KIDNEYcon- a yearly hands-on conference dedicated to advances in nephrology held in Little Rock, AR each April. Listen to the Freely Filtered Podcast.

@Nephro_Sparks on Twitter

Education and Training

  • Fellow in Nephrology, Medicine, Duke University School of Medicine, 2007 - 2011
  • Chief Resident, Medicine, University of Arkansas for Medical Sciences, College of Medicine, 2006 - 2007
  • Resident, Medicine, University of Arkansas for Medical Sciences, College of Medicine, 2003 - 2006
  • M.D., University of Arkansas for Medical Sciences, College of Medicine, 2003

Publications

Rein, Joshua L., Matthew A. Sparks, Rachel Hilburg, and Samira S. Farouk. “Tackling acid-base disorders, one Twitter poll at a time.” Adv Physiol Educ 44, no. 4 (December 1, 2020): 706–8. https://doi.org/10.1152/advan.00099.2020.

PMID
33079564
Full Text

Sparks, Matthew A., Andrew M. South, Andrew D. Badley, Carissa M. Baker-Smith, Daniel Batlle, Biykem Bozkurt, Roberto Cattaneo, et al. “Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19, and the Renin-Angiotensin System: Pressing Needs and Best Research Practices.” Hypertension 76, no. 5 (November 2020): 1350–67. https://doi.org/10.1161/HYPERTENSIONAHA.120.15948.

PMID
32981369
Full Text

Tio, Maria Clarissa, Matthew A. Sparks, and Javier A. Neyra. “The International Biomedical Workforce is Critical to Our Response to COVID-19 in the United States.” Mayo Clin Proc 95, no. 11 (November 2020): 2336–38. https://doi.org/10.1016/j.mayocp.2020.09.012.

PMID
33153624
Full Text

Ng, Jia H., Vanesa Bijol, Matthew A. Sparks, Meghan E. Sise, Hassane Izzedine, and Kenar D. Jhaveri. “Pathophysiology of Acute Kidney Injury in Patients with COVID-19.” Advances in Chronic Kidney Disease, October 2020. https://doi.org/10.1053/j.ackd.2020.09.003.

Full Text

Provenzano, Anthony M., and Matthew A. Sparks. “The renin-angiotensin-aldosterone system update: full-court press.” Nephrol Dial Transplant 35, no. 9 (September 1, 2020): 1488–90. https://doi.org/10.1093/ndt/gfz123.

PMID
31665432
Full Text

Edmonston, Daniel L., and Matthew A. Sparks. “Therapeutic options for chronic kidney disease-associated pulmonary hypertension.” Curr Opin Nephrol Hypertens 29, no. 5 (September 2020): 497–507. https://doi.org/10.1097/MNH.0000000000000624.

PMID
32657794
Full Text

Hindi, Judy, Nicholas Fuca, Matthew A. Sparks, Joshua L. Rein, and Samira S. Farouk. “Severe Acidemia in a Patient With Waldenström Macroglobulinemia.” Kidney Int Rep 5, no. 9 (September 2020): 1586–89. https://doi.org/10.1016/j.ekir.2020.06.023.

PMID
32954085
Full Text

Batlle, Daniel, Maria Jose Soler, Matthew A. Sparks, Swapnil Hiremath, Andrew M. South, Paul A. Welling, Sundararaman Swaminathan, and Sundararaman COVID-19 and ACE2 in Cardiovascular, Lung, and Kidney Working Group. “Acute Kidney Injury in COVID-19: Emerging Evidence of a Distinct Pathophysiology.” Journal of the American Society of Nephrology : Jasn 31, no. 7 (July 2020): 1380–83. https://doi.org/10.1681/asn.2020040419.

PMID
32366514
Full Text

Pages