Matthias Gromeier, MD

Professor of Neurosurgery
Professor in Molecular Genetics and Microbiology
Professor in Medicine
Member of the Duke Cancer Institute
Campus mail Box 3020 Med Ctr, Durham, NC 27710
Phone (919) 668-6205
Email address grome001@mc.duke.edu

I am a classically trained virologist with a focus on molecular mechanisms of RNA virus pathogenesis. My career is dedicated to unraveling RNA virus:host relations and devising methods of exploiting them for cancer immunotherapy and vaccine design. My background is in translation regulation and mRNA metabolism, viral RNA sensing and innate immunity, and cancer immunology and immunotherapy. Basic mechanistic research in my laboratory is supporting an ambitious clinical translational research program with active multi-center clinical trials in several cancer indications. 

Education and Training

  • Postdoctoral Associate, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1996 - 1999
  • Postdoctoral fellow, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1993 - 1996
  • M.D., University of Hamburg (Germany), 1992

Publications

Bradrick, Shelton S., Robert W. Walters, and Matthias Gromeier. “The hepatitis C virus 3'-untranslated region or a poly(A) tract promote efficient translation subsequent to the initiation phase.” Nucleic Acids Res 34, no. 4 (2006): 1293–1303. https://doi.org/10.1093/nar/gkl019.

PMID
16510853
Full Text

Gromeier, M., E. Y. Dobrikova, M. K. Merrill, S. A. Moore, C. Kaiser, R. Grisham, and L. Selznick. “Non-pathogenic poliovirus recombinants for the treatment of malignant glioma.” In Neuro Oncology, 7:382–382. DUKE UNIV PRESS, 2005.

Scholars@Duke

Florez, Paola M., October M. Sessions, Eric J. Wagner, Matthias Gromeier, and Mariano A. Garcia-Blanco. “The polypyrimidine tract binding protein is required for efficient picornavirus gene expression and propagation.” J Virol 79, no. 10 (May 2005): 6172–79. https://doi.org/10.1128/JVI.79.10.6172-6179.2005.

PMID
15858002
Full Text

Campbell, Stephanie A., Jennifer Lin, Elena Y. Dobrikova, and Matthias Gromeier. “Genetic determinants of cell type-specific poliovirus propagation in HEK 293 cells.” J Virol 79, no. 10 (May 2005): 6281–90. https://doi.org/10.1128/JVI.79.10.6281-6290.2005.

PMID
15858012
Full Text

Campbell, Stephanie A., and Matthias Gromeier. “Oncolytic viruses for cancer therapy II. Cell-internal factors for conditional growth in neoplastic cells.” Onkologie 28, no. 4 (April 2005): 209–15. https://doi.org/10.1159/000084010.

PMID
15840970
Full Text

Campbell, Stephanie A., and Matthias Gromeier. “Oncolytic viruses for cancer therapy I. Cell-external factors: virus entry and receptor interaction.” Onkologie 28, no. 3 (March 2005): 144–49. https://doi.org/10.1159/000083659.

PMID
15772465
Full Text

Dufresne, Andrew T., and Matthias Gromeier. “A nonpolio enterovirus with respiratory tropism causes poliomyelitis in intercellular adhesion molecule 1 transgenic mice.” Proc Natl Acad Sci U S A 101, no. 37 (September 14, 2004): 13636–41. https://doi.org/10.1073/pnas.0403998101.

PMID
15353596
Full Text

Ochiai, Hidenobu, Stephanie A. Moore, Gary E. Archer, Tatsunori Okamura, Tracy A. Chewning, Jeffrey R. Marks, John H. Sampson, and Matthias Gromeier. “Treatment of intracerebral neoplasia and neoplastic meningitis with regional delivery of oncolytic recombinant poliovirus.” Clin Cancer Res 10, no. 14 (July 15, 2004): 4831–38. https://doi.org/10.1158/1078-0432.CCR-03-0694.

PMID
15269159
Full Text

Merrill, Melinda K., Guenter Bernhardt, John H. Sampson, Carol J. Wikstrand, Darell D. Bigner, and Matthias Gromeier. “Poliovirus receptor CD155-targeted oncolysis of glioma.” Neuro Oncol 6, no. 3 (July 2004): 208–17. https://doi.org/10.1215/S1152851703000577.

PMID
15279713
Full Text

Pages