Matthias Gromeier, MD

Professor of Neurosurgery
Professor in Molecular Genetics and Microbiology
Professor in Medicine
Member of the Duke Cancer Institute
Campus mail Box 3020 Med Ctr, Durham, NC 27710
Phone (919) 668-6205
Email address grome001@mc.duke.edu

I am a classically trained virologist with a focus on molecular mechanisms of RNA virus pathogenesis. My career is dedicated to unraveling RNA virus:host relations and devising methods of exploiting them for cancer immunotherapy and vaccine design. My background is in translation regulation and mRNA metabolism, viral RNA sensing and innate immunity, and cancer immunology and immunotherapy. Basic mechanistic research in my laboratory is supporting an ambitious clinical translational research program with active multi-center clinical trials in several cancer indications. 

Education and Training

  • Postdoctoral Associate, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1996 - 1999
  • Postdoctoral fellow, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1993 - 1996
  • M.D., University of Hamburg (Germany), 1992

Publications

Desjardins, Annick, John Howard Sampson, Katherine B. Peters, Tulika Ranjan, Gordana Vlahovic, Stevie Threatt, James Emmett Herndon, et al. “Dose-finding and safety study of an oncolytic polio/rhinovirus recombinant against recurrent glioblastoma.” In Journal of Clinical Oncology, Vol. 31, 2013.

Scholars@Duke

Chandramohan, V., D. A. Mitchell, M. Gromeier, J. H. Sampson, and D. D. Bigner. “Current immunotherapeutic targets in gliomas,” May 1, 2013, 287–305.

Scholars@Duke

Gromeier, Matthias, Annick Desjardins, John H. Sampson, Stevie J. E. Threatt, James E. Herndon, Allan Friedman, Henry S. Friedman, and Darell D. Bigner. “ONCOLYTIC POLIOVIRUS IMMUNOTHERAPY OF PRIMARY CNS TUMORS.” In Neuro Oncology, 15:20–20. OXFORD UNIV PRESS INC, 2013.

Scholars@Duke

Dobrikov, Mikhail I., Elena Y. Dobrikova, and Matthias Gromeier. “Dynamic regulation of the translation initiation helicase complex by mitogenic signal transduction to eukaryotic translation initiation factor 4G.” Mol Cell Biol 33, no. 5 (March 2013): 937–46. https://doi.org/10.1128/MCB.01441-12.

PMID
23263986
Full Text

Barton, Kelly L., Katherine Misuraca, Francisco Cordero, Elena Dobrikova, Hooney D. Min, Matthias Gromeier, David G. Kirsch, and Oren J. Becher. “PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma.” Plos One 8, no. 10 (2013): e77639. https://doi.org/10.1371/journal.pone.0077639.

PMID
24098593
Full Text

Lawson, Sarah K., Elena Y. Dobrikova, Mayya Shveygert, and Matthias Gromeier. “p38α mitogen-activated protein kinase depletion and repression of signal transduction to translation machinery by miR-124 and -128 in neurons.” Mol Cell Biol 33, no. 1 (January 2013): 127–35. https://doi.org/10.1128/MCB.00695-12.

PMID
23109423
Full Text

Dobrikova, Elena Y., Christian Goetz, Robert W. Walters, Sarah K. Lawson, James O. Peggins, Karen Muszynski, Sheryl Ruppel, et al. “Attenuation of neurovirulence, biodistribution, and shedding of a poliovirus:rhinovirus chimera after intrathalamic inoculation in Macaca fascicularis.” J Virol 86, no. 5 (March 2012): 2750–59. https://doi.org/10.1128/JVI.06427-11.

PMID
22171271
Full Text

Goetz, Christian, Elena Dobrikova, Mayya Shveygert, Mikhail Dobrikov, and Matthias Gromeier. “Oncolytic poliovirus against malignant glioma.” Future Virol 6, no. 9 (September 2011): 1045–58. https://doi.org/10.2217/fvl.11.76.

PMID
21984883
Full Text

Dobrikov, Mikhail, Elena Dobrikova, Mayya Shveygert, and Matthias Gromeier. “Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1.” Molecular and Cellular Biology 31, no. 14 (July 2011): 2947–59. https://doi.org/10.1128/mcb.05589-11.

PMID
21576361
Full Text

Wang, Eric S., Elena Dobrikova, Christian Goetz, Andrew T. Dufresne, and Matthias Gromeier. “Adaptation of an ICAM-1-tropic enterovirus to the mouse respiratory tract.” Journal of Virology 85, no. 11 (June 2011): 5606–17. https://doi.org/10.1128/jvi.01502-10.

PMID
21450825
Full Text

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