Megan Elizabeth Bowles Clowse, MD

Associate Professor of Medicine
Campus mail Baker House 07, Duke South, Trent Drive, Durham, NC 27710
Phone (919) 681-2045
Email address megan.clowse@duke.edu

I am a clinical researcher with a focus on the management of rheumatologic diseases in pregnancy.  Since 2007, I have collected prospective pregnancies in women with rheumatic disease in the Duke Autoimmunity in Pregnancy Registry, which currently includes over 300 pregnancies.  This registry includes clinical data, pregnancy outcomes, and a large sample repository.  In collaboration with Duke Pediatric Cardiology, we found that maternal use of hydroxychloroquine may be protective against congenital heart block from neonatal lupus.  I have also conducted studies on vasculitis and ovarian function and pregnancy and I am the director of the Vasculitis-Pregnancy Registry, through the Vasculitis Clinical Research Consortium, is an online pregnancy registry for women with these rare conditions.  I am starting a study to identify causes for the high rate of infertility among women with rheumatoid arthrits.  I am also working on several projects to better understand how psoriatic arthritis impacts pregnancy.  

Education and Training

  • Fellow In Rheumatology, Medicine, Johns Hopkins University, 2002 - 2005
  • Medical Residetn, Medicine, Johns Hopkins University, 1999 - 2002
  • M.D., Vanderbilt University, 1999
  • M.P.H., University of California at Los Angeles, 1994

Publications

Aranow, C, Kamen, DL, Dall'Era, M, Massarotti, EM, Mackay, MC, Koumpouras, F, Coca, A, Chatham, WW, Clowse, MEB, Criscione-Schreiber, LG, Callahan, S, Goldmuntz, EA, Keyes-Elstein, L, Oswald, M, Gregersen, PK, and Diamond, B. "Randomized, Double-Blind, Placebo-Controlled Trial of the Effect of Vitamin D-3 on the Interferon Signature in Patients With Systemic Lupus Erythematosus." ARTHRITIS & RHEUMATOLOGY 67, no. 7 (July 2015): 1848-1857.

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Østensen, M, Andreoli, L, Brucato, A, Cetin, I, Chambers, C, Clowse, ME, Costedoat-Chalumeau, N, Cutolo, M, Dolhain, R, Fenstad, MH, Förger, F, Wahren-Herlenius, M, Ruiz-Irastorza, G, Koksvik, H, Nelson-Piercy, C, Shoenfeld, Y, Tincani, A, Villiger, PM, Wallenius, M, and von Wolff, M. "State of the art: Reproduction and pregnancy in rheumatic diseases." Autoimmunity reviews 14, no. 5 (May 2015): 376-386. (Review)

PMID
25555818
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Kavanaugh, A, Cush, JJ, Ahmed, MS, Bermas, BL, Chakravarty, E, Chambers, C, Clowse, M, Curtis, JR, Dao, K, Hankins, GD, Koren, G, Kim, SC, Lapteva, L, Mahadevan, U, Moore, T, Nolan, M, Ren, Z, Sammaritano, LR, Seymour, S, and Weisman, MH. "Proceedings from the American College of Rheumatology Reproductive Health Summit: the management of fertility, pregnancy, and lactation in women with autoimmune and systemic inflammatory diseases." Arthritis care & research 67, no. 3 (March 2015): 313-325.

PMID
25385050
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Noviani, M, Wasserman, S, Achneck, HE, and Clowse, MEB. "Breastfeeding Practice in Patients with Systemic Lupus Erythematosus." CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 33, no. 3 (2015): S49-S49.

Scholars@Duke

Wasserman, S, and Clowse, MEB. "Systemic Lupus Erythematosus and Lactation: Factors Affecting Infant Feeding Choices in Women with SLE." ARTHRITIS & RHEUMATOLOGY 66 (October 2014): S1168-S1168.

Scholars@Duke

Grossman, JM, Clowse, MEB, Izmirly, PM, Kamen, DL, Levine, AK, Mackey, M, McCune, WJ, McGwin, J, Pisetsky, DS, Utset, T, and Yazdany, J. "Hydroxychloroquine Dosing and Disease Activity in a Large Multi-Racial Lupus Cohort." ARTHRITIS & RHEUMATOLOGY 66 (October 2014): S296-S297.

Scholars@Duke

Clowse, MEB. "Comparison of Rheumatoid Arthritis, Ankylosing Spondylitis, and Psoriatic Arthritis Pregnancies: Disease Activity, Treatment, and Outcomes." ARTHRITIS & RHEUMATOLOGY 66 (October 2014): S706-S707.

Scholars@Duke

Clowse, MEB, Wolf, DC, Foerger, F, Cush, JJ, Golembesky, A, Shaughnessy, L, De Cuyper, D, Luijtens, K, Abbas, S, and Mahadevan, U. "Pregnancy Outcomes after Exposure to Certolizumab Pegol: Updated Results from Safety Surveillance." ARTHRITIS & RHEUMATOLOGY 66 (October 2014): S621-S622.

Scholars@Duke

Clowse, MEB, Khamashta, M, Pushparajah, DS, and Chakravarty, E. "Care of Women with Rheumatological Conditions during Family Planning and Pregnancy." ARTHRITIS & RHEUMATOLOGY 66 (October 2014): S598-S598.

Scholars@Duke

Gordon, C, Chakravarty, E, Pushparajah, DS, Dewulf, L, and Clowse, MEB. "THU0430 A Survey on Patient and Physician Perspectives on Family Planning and Pregnancy Issues – Does Condition Matter?." June 2014.

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