Megan Elizabeth Bowles Clowse, MD

Associate Professor of Medicine
Campus mail Baker House 07, Duke South, Trent Drive, Durham, NC 27710
Phone (919) 681-2045
Email address megan.clowse@duke.edu

I am a clinical researcher with a focus on the management of rheumatologic diseases in pregnancy.  Since 2007, I have collected prospective pregnancies in women with rheumatic disease in the Duke Autoimmunity in Pregnancy Registry, which currently includes over 300 pregnancies.  This registry includes clinical data, pregnancy outcomes, and a large sample repository.  In collaboration with Duke Pediatric Cardiology, we found that maternal use of hydroxychloroquine may be protective against congenital heart block from neonatal lupus.  I have also conducted studies on vasculitis and ovarian function and pregnancy and I am the director of the Vasculitis-Pregnancy Registry, through the Vasculitis Clinical Research Consortium, is an online pregnancy registry for women with these rare conditions.  I am starting a study to identify causes for the high rate of infertility among women with rheumatoid arthrits.  I am also working on several projects to better understand how psoriatic arthritis impacts pregnancy.  

In Their Words

Education and Training

  • Fellow in Rheumatology, Medicine, Johns Hopkins University, 2002 - 2005
  • Medical Residetn, Medicine, Johns Hopkins University, 1999 - 2002
  • M.D., Vanderbilt University, 1999
  • M.P.H., University of California at Los Angeles, 1994

Publications

Kimball, AB, Clowse, MEB, Scheuerle, AE, Chambers, C, Afzali, A, Cush, JJ, Cooney, M, Shauhnessy, L, Vanderkelen, M, and Forger, F. "Characteristics and outcomes of pregnancies exposed to certolizumab pegol prospectively reported to a safety database." Annual Meeting of the American-Academy-of-Dermatology (AAD). San Diego, CA. February 16, 2018 - February 20, 2018.: MOSBY-ELSEVIER, September 1, 2018.

Scholars@Duke

Kimball, AB, Clowse, MEB, Scheuerle, AE, Chambers, C, Afzali, A, Cush, JJ, Cooney, M, Shauhnessy, L, Vanderkelen, M, and Forger, F. "Characteristics and outcomes of pregnancies exposed to certolizumab pegol prospectively reported to a safety database." Annual Meeting of the American-Academy-of-Dermatology (AAD). San Diego, CA. February 16, 2018 - February 20, 2018.: MOSBY-ELSEVIER, September 1, 2018.

Scholars@Duke

Clowse, MEB, Scheuerle, AE, Chambers, C, Afzali, A, Kimball, AB, Cush, JJ, Cooney, M, Shaughnessy, L, Vanderkelen, M, and Förger, F. "Pregnancy Outcomes After Exposure to Certolizumab Pegol: Updated Results From a Pharmacovigilance Safety Database." Arthritis & Rheumatology (Hoboken, N.J.) 70, no. 9 (September 2018): 1399-1407.

PMID
29623679
Full Text

Birru Talabi, M, Clowse, MEB, Blalock, SJ, Moreland, L, Siripong, N, and Borrero, S. "Contraception Use Among Reproductive-Age Women with Rheumatic Diseases." Arthritis Care & Research (August 14, 2018).

PMID
30106516
Full Text

Eudy, AM, Siega-Riz, AM, Engel, SM, Franceschini, N, Howard, AG, Clowse, MEB, and Petri, M. "Preconceptional Cardiovascular Health and Pregnancy Outcomes in Women with Systemic Lupus Erythematosus." The Journal of Rheumatology (July 15, 2018).

PMID
30008449
Full Text

Mahadevan, U, Dubinsky, MC, Su, C, Lawendy, N, Jones, TV, Marren, A, Zhang, H, Graham, D, Clowse, MEB, Feldman, SR, and Baumgart, DC. "Outcomes of Pregnancies With Maternal/Paternal Exposure in the Tofacitinib Safety Databases for Ulcerative Colitis." Inflammatory Bowel Diseases (July 2, 2018).

PMID
29982686
Full Text

Clowse, MEB, Eudy, AM, Kiernan, E, Williams, MR, Bermas, B, Chakravarty, E, Sammaritano, LR, Chambers, CD, and Buyon, J. "The prevention, screening and treatment of congenital heart block from neonatal lupus: a survey of provider practices." July 2018.

PMID
30137589
Full Text

Vinet, E, Chakravarty, EF, and Clowse, MEB. "Power in numbers." Rheumatology (Oxford, England) 57, no. suppl_5 (July 2018): v40-v47.

PMID
30137590
Full Text

Bermas, BL, Tassinari, M, Clowse, M, and Chakravarty, E. "The new FDA labeling rule: impact on prescribing rheumatological medications during pregnancy." Rheumatology (Oxford, England) 57, no. suppl_5 (July 2018): v2-v8. (Review)

PMID
30137587
Full Text

Harris, N, Eudy, A, and Clowse, M. "Patient-Reported Disease Activity and Adverse Pregnancy Outcomes in Systemic Lupus Erythematosus and Rheumatoid Arthritis." June 15, 2018.

PMID
29908013
Full Text

Pages