Megan Elizabeth Bowles Clowse, MD

Associate Professor of Medicine
Campus mail Baker House 07, Duke South, Trent Drive, Durham, NC 27710
Phone (919) 681-2045
Email address megan.clowse@duke.edu

Dr. Megan Clowse is an Associate Professor of Medicine in the Division of Rheumatology and Immunology.  Her clinical research focuses on the management of rheumatic diseases in pregnancy. She has cared for over 600 pregnancies in women with rheumatic disease, collecting information on these pregnancies initially in the Duke Autoimmunity in Pregnancy Registry and Repository, and now the MADRA (Maternal Autoimmune Disease Research Alliance) registry and repository.  She served on the Core Leadership Team for the inaugural American College of Rheumatology's Reproductive Health Guidelines, published January 2020.  Dr. Clowse created www.LupusPregnancy.org, a website dedicated to improving lupus pregnancy planning and management for patients and rheumatologists.  

Dr. Clowse was the founding director of the Duke Lupus Clinic, where she continues to see patients each week and mentor junior faculty researchers.  The team has developed a new approach to lupus classification and management and is currently collecting and analyzing patient- and physician-reported measures to  better clarify this construct.  

As the Co-Director of Duke Forge, Dr. Clowse has shepherding multiple Department of Medicine-funded studies to identify and build innovative approaches to using health data to improve patient care. 

In Their Words

Education and Training

  • Fellow in Rheumatology, Medicine, Johns Hopkins University, 2002 - 2005
  • Medical Residetn, Medicine, Johns Hopkins University, 1999 - 2002
  • M.D., Vanderbilt University, 1999
  • M.P.H., University of California - Los Angeles, 1994

Publications

Barnado, April, Amanda M. Eudy, Ashley Blaske, Lee Wheless, Katie Kirchoff, Jim C. Oates, and Megan E. B. Clowse. “Developing and Validating Methods to Assemble Systemic Lupus Erythematosus Births in the Electronic Health Record.” Arthritis Care Res (Hoboken) 74, no. 5 (May 2022): 849–57. https://doi.org/10.1002/acr.24522.

PMID
33253488
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Eudy, Amanda M., Bryce B. Reeve, Theresa Coles, Li Lin, Jennifer L. Rogers, David S. Pisetsky, Lisa G. Criscione-Schreiber, et al. “The use of patient-reported outcome measures to classify type 1 and 2 systemic lupus erythematosus activity.” Lupus 31, no. 6 (May 2022): 697–705. https://doi.org/10.1177/09612033221090885.

PMID
35343853
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Clowse, M., R. Fischer-Betz, C. Nelson-Piercy, A. E. Scheuerle, B. Stephan, M. Dubinsky, T. Kumke, R. Kasliwal, B. Lauwerys, and F. Förger. “Pharmacovigilance pregnancy data in a large population of patients with chronic inflammatory disease exposed to certolizumab pegol.” Therapeutic Advances in Musculoskeletal Disease 14 (April 1, 2022). https://doi.org/10.1177/1759720X221087650.

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Maheswaranathan, Mithu, Philip Chu, Andrew Johannemann, Lisa Criscione-Schreiber, Megan Clowse, and David L. Leverenz. “The Impact of the COVID-19 Pandemic and Telemedicine Implementation on Practice Patterns and Electronic Health Record Utilization in an Academic Rheumatology Practice.” J Clin Rheumatol 28, no. 2 (March 1, 2022): e612–15. https://doi.org/10.1097/RHU.0000000000001751.

PMID
33843775
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Aringer, M., M. E. Alarcón-Riquelme, M. Clowse, G. J. Pons-Estel, E. M. Vital, and M. Dall’Era. “A glimpse into the future of systemic lupus erythematosus.” Therapeutic Advances in Musculoskeletal Disease 14 (March 1, 2022). https://doi.org/10.1177/1759720X221086719.

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Clowse, Megan E. B., Amanda M. Eudy, Stephen Balevic, Gillian Sanders-Schmidler, Andrzej Kosinski, Rebecca Fischer-Betz, Dafna D. Gladman, et al. “Hydroxychloroquine in the pregnancies of women with lupus: a meta-analysis of individual participant data.” Lupus Sci Med 9, no. 1 (March 2022). https://doi.org/10.1136/lupus-2021-000651.

PMID
35318256
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Bermas, B. L., M. Gianfrancesco, H. L. Tanner, A. M. Seet, M. C. Aguiar, N. K. Al Adhoubi, S. Al Emadi, et al. “COVID-19 in Pregnant Women With Rheumatic Disease: Data From the COVID-19 Global Rheumatology Alliance.” In Journal of Rheumatology, 49:110–14, 2022. https://doi.org/10.3899/jrheum.210480.

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Balevic, Stephen J., Daniel Weiner, Megan E. B. Clowse, Amanda M. Eudy, Anil R. Maharaj, Christoph P. Hornik, Michael Cohen-Wolkowiez, and Daniel Gonzalez. “Hydroxychloroquine PK and exposure-response in pregnancies with lupus: the importance of adherence for neonatal outcomes.” Lupus Sci Med 9, no. 1 (January 2022). https://doi.org/10.1136/lupus-2021-000602.

PMID
34996856
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Pagidipati, Neha J., Matthew Phelan, Courtney Page, Megan Clowse, Ricardo Henao, Eric D. Peterson, and Benjamin A. Goldstein. “The importance of weight stabilization amongst those with overweight or obesity: Results from a large health care system.” Prev Med Rep 24 (December 2021): 101615. https://doi.org/10.1016/j.pmedr.2021.101615.

PMID
34976671
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Birru Talabi, Mehret, Katherine P. Himes, and Megan E. B. Clowse. “Optimizing reproductive health management in lupus and Sjogren's syndrome.” Curr Opin Rheumatol 33, no. 6 (November 1, 2021): 570–78. https://doi.org/10.1097/BOR.0000000000000839.

PMID
34519280
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