Megan Elizabeth Bowles Clowse, MD

Associate Professor of Medicine
Campus mail Baker House 07, Duke South, Trent Drive, Durham, NC 27710
Phone (919) 681-2045
Email address megan.clowse@duke.edu

I am a clinical researcher with a focus on the management of rheumatologic diseases in pregnancy.  Since 2007, I have collected prospective pregnancies in women with rheumatic disease in the Duke Autoimmunity in Pregnancy Registry, which currently includes over 300 pregnancies.  This registry includes clinical data, pregnancy outcomes, and a large sample repository.  In collaboration with Duke Pediatric Cardiology, we found that maternal use of hydroxychloroquine may be protective against congenital heart block from neonatal lupus.  I have also conducted studies on vasculitis and ovarian function and pregnancy and I am the director of the Vasculitis-Pregnancy Registry, through the Vasculitis Clinical Research Consortium, is an online pregnancy registry for women with these rare conditions.  I am starting a study to identify causes for the high rate of infertility among women with rheumatoid arthrits.  I am also working on several projects to better understand how psoriatic arthritis impacts pregnancy.  

In Their Words

Education and Training

  • Fellow in Rheumatology, Medicine, Johns Hopkins University, 2002 - 2005
  • Medical Residetn, Medicine, Johns Hopkins University, 1999 - 2002
  • M.D., Vanderbilt University, 1999
  • M.P.H., University of California at Los Angeles, 1994

Publications

Mariette, X, Clowse, M, Förger, F, Hwang, C, Thorp, J, Dolhain, R, Van Tubergen, A, Shaughnessy, L, Simpson, J, Teil, M, Toublanc, N, Wang, M, and Hale, T. "Évaluation du passage du certolizumab pegol dans le lait maternel: résultats d’une étude de pharmacocinétique post-AMM, prospective, multicentrique." Revue du Rhumatisme 83 (November 2016): A100-A102.

Full Text

Clowse, MEB, and Grotegut, C. "Racial and Ethnic Disparities in the Pregnancies of Women With Systemic Lupus Erythematosus." Arthritis care & research 68, no. 10 (October 2016): 1567-1572.

PMID
26815791
Full Text

Noviani, M, Wasserman, S, and Clowse, MEB. "Breastfeeding in mothers with systemic lupus erythematosus." Lupus 25, no. 9 (August 2016): 973-979.

PMID
26888577
Full Text

Clowse, MEB, Feldman, SR, Isaacs, JD, Kimball, AB, Strand, V, Warren, RB, Xibillé, D, Chen, Y, Frazier, D, Geier, J, Proulx, J, and Marren, A. "Pregnancy Outcomes in the Tofacitinib Safety Databases for Rheumatoid Arthritis and Psoriasis." Drug safety 39, no. 8 (August 2016): 755-762.

PMID
27282428
Full Text

Duan-Porter, W, Goldstein, KM, McDuffie, JR, Hughes, JM, Clowse, MEB, Klap, RS, Masilamani, V, Allen LaPointe, NM, Nagi, A, Gierisch, JM, and Williams, JW. "Reporting of Sex Effects by Systematic Reviews on Interventions for Depression, Diabetes, and Chronic Pain." Annals of internal medicine 165, no. 3 (August 2016): 184-193.

PMID
27111355
Full Text

Cohen, S, Clowse, M, Pardo, P, Bhattacharya, I, Menon, S, Gourley, I, and Diehl, A. "Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Properties of SBI-087, a CD20-Directed B-cell Depleting Agent: Phase 1 Dose Escalating Studies in Patients With Either Mild Rheumatoid Arthritis or Systemic Lupus." Clinical therapeutics 38, no. 6 (June 2016): 1417-1434.e2.

PMID
27112532
Full Text

Wallace, DJ, Hobbs, K, Clowse, MEB, Petri, M, Strand, V, Pike, M, Merrill, JT, Leszczyński, P, Neuwelt, CM, Jeka, S, Houssiau, F, Keiserman, M, Ordi-Ros, J, Bongardt, S, Kilgallen, B, Galateanu, C, Kalunian, K, Furie, R, and Gordon, C. "Long-Term Safety and Efficacy of Epratuzumab in the Treatment of Moderate-to- Severe Systemic Lupus Erythematosus: Results From an Open-Label Extension Study." Arthritis care & research 68, no. 4 (April 2016): 534-543.

PMID
26316325
Full Text

Clowse, MEB, Wolf, DC, Förger, F, Cush, JJ, Golembesky, A, Shaughnessy, L, De Cuyper, D, and Mahadevan, U. "Pregnancy Outcomes in Subjects Exposed to Certolizumab Pegol." The Journal of rheumatology 42, no. 12 (December 2015): 2270-2278.

PMID
26523031
Full Text

Aranow, C, Kamen, DL, Dall'Era, M, Massarotti, EM, Mackay, MC, Koumpouras, F, Coca, A, Chatham, WW, Clowse, MEB, Criscione-Schreiber, LG, Callahan, S, Goldmuntz, EA, Keyes-Elstein, L, Oswald, M, Gregersen, PK, and Diamond, B. "Randomized, Double-Blind, Placebo-Controlled Trial of the Effect of Vitamin D-3 on the Interferon Signature in Patients With Systemic Lupus Erythematosus." ARTHRITIS & RHEUMATOLOGY 67, no. 7 (July 2015): 1848-1857.

Full Text

Østensen, M, Andreoli, L, Brucato, A, Cetin, I, Chambers, C, Clowse, MEB, Costedoat-Chalumeau, N, Cutolo, M, Dolhain, R, Fenstad, MH, Förger, F, Wahren-Herlenius, M, Ruiz-Irastorza, G, Koksvik, H, Nelson-Piercy, C, Shoenfeld, Y, Tincani, A, Villiger, PM, Wallenius, M, and von Wolff, M. "State of the art: Reproduction and pregnancy in rheumatic diseases." Autoimmunity reviews 14, no. 5 (May 2015): 376-386. (Review)

PMID
25555818
Full Text

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