Megan Elizabeth Bowles Clowse, MD

Associate Professor of Medicine
Campus mail Baker House 07, Duke South, Trent Drive, Durham, NC 27710
Phone (919) 681-2045
Email address megan.clowse@duke.edu

I am a clinical researcher with a focus on the management of rheumatologic diseases in pregnancy.  Since 2007, I have collected prospective pregnancies in women with rheumatic disease in the Duke Autoimmunity in Pregnancy Registry, which currently includes over 300 pregnancies.  This registry includes clinical data, pregnancy outcomes, and a large sample repository.  In collaboration with Duke Pediatric Cardiology, we found that maternal use of hydroxychloroquine may be protective against congenital heart block from neonatal lupus.  I have also conducted studies on vasculitis and ovarian function and pregnancy and I am the director of the Vasculitis-Pregnancy Registry, through the Vasculitis Clinical Research Consortium, is an online pregnancy registry for women with these rare conditions.  I am starting a study to identify causes for the high rate of infertility among women with rheumatoid arthrits.  I am also working on several projects to better understand how psoriatic arthritis impacts pregnancy.  

In Their Words

Education and Training

  • Fellow in Rheumatology, Medicine, Johns Hopkins University, 2002 - 2005
  • Medical Residetn, Medicine, Johns Hopkins University, 1999 - 2002
  • M.D., Vanderbilt University, 1999
  • M.P.H., University of California at Los Angeles, 1994

Publications

Pedro, S, Chakravarty, E, Clowse, MEB, Schumacher, R, and Michaud, K. "The Impact Of Menopause In Rheumatoid Arthritis Activity." October 2013.

Scholars@Duke

Clowse, MEB, Houssiau, F, Petri, MA, Kilgallen, B, Kalunian, K, Strand, V, Bongardt, S, Gordon, C, and Wallace, DJ. "Epratuzumab Maintains Improvements In Disease Activity For Over 2 Years In Patients With Moderate-To-Severe Systemic Lupus Erythematosus: Results From An Open-Label Long-Term Extension Study." October 2013.

Scholars@Duke

Clowse, MEB, Chakravarty, E, Pushparajah, DS, Mertens, S, and Gordon, C. "Patient and Physician Perspectives On Family Planning and Pregnancy Issues In Systemic Inflammatory Diseases: Mind The Gap!." October 2013.

Scholars@Duke

Clowse, MEB, Grossman, JM, Merrill, JT, Askanase, A, Dvorkina, O, Lockshin, MD, and Aranow, C. "Predictors Of Damage Accrual Over a 2 Year Period In a Large Multi-Racial/Ethnic Lupus Cohort." October 2013.

Scholars@Duke

Kalunian, K, Clowse, MEB, Houssiau, F, Petri, MA, Kilgallen, B, Gordon, C, Strand, V, Bongardt, S, and Wallace, DJ. "Sustained British Isles Lupus Assessment Group-Measured Improvement In Moderately-and-Severely Affected Body Systems In Patients With Systemic Lupus Erythematosus By Epratuzumab: Results From An Open-Label Extension Study." October 2013.

Scholars@Duke

Chaudhary, P, and Clowse, MEB. "Prednisone Use Associated With Worse Outcomes In Rheumatoid Arthritis Pregnancies." October 2013.

Scholars@Duke

Clowse, MEB, Wallace, DJ, Weisman, M, James, A, Criscione-Schreiber, LG, and Pisetsky, DS. "Predictors of preterm birth in patients with mild systemic lupus erythematosus." Ann Rheum Dis 72, no. 9 (September 1, 2013): 1536-1539.

PMID
23361085
Full Text

Karol, DE, Criscione-Schreiber, LG, Lin, M, and Clowse, MEB. "Depressive symptoms and associated factors in systemic lupus erythematosus." Psychosomatics 54, no. 5 (September 2013): 443-450.

PMID
23274009
Full Text

Somers, TJ, Kurakula, PC, Criscione-Schreiber, L, Keefe, FJ, and Clowse, MEB. "Reply: To PMID 22505314." Arthritis Care Res (Hoboken) 65, no. 7 (July 2013): 1205-. (Letter)

PMID
23371927
Full Text

Tunks, RD, Clowse, MEB, Miller, SG, Brancazio, LR, and Barker, PCA. "Maternal autoantibody levels in congenital heart block and potential prophylaxis with antiinflammatory agents." Am J Obstet Gynecol 208, no. 1 (January 2013): 64.e1-64.e7.

PMID
23063019
Full Text

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