Michael Arthur Hauser, PhD

Professor in Medicine
Associate Research Professor in Molecular Genetics and Microbiology
Member of Duke Molecular Physiology Institute
Campus mail 2016 Genome Science Research Bldg I, Durham, NC 27710
Phone (919) 684-3508
Email address mike.hauser@duke.edu

Dr. Hauser has a strong interest in ocular genetics. Genomic studies at the Center for Human Genetics have identified multiple linkage peaks and susceptibility genes in primary open angle glaucoma (POAG) and age related macular degeneration (AMD). Dr. Hauser has recently accepted a 20% appointment at the Singapore Eye Research INstitute and the Duke/National University of Singapore.  In collaboration with multiple collaborators in Singapore, and Dr. Rand Allingham at the Duke Eye Center, Dr. Hauser is currently conducting a genome wide association study for glaucoma in individuals of African ancestry. These investigations include large datasets collected in Ghana, Nigeria, and South Africa.  
 
Dr. Hauser is also involved in collaborative investigations into the genetics of post-tramatic stress disorder in US veterans from Iraq and Afghanistan.   Major collaborators include Dr. Allison Ashley Koch, Dr. Jean Beckham, Dr. Christine Marx and the MIRECC Collaborative group at the Durham Veteran's Administration.  We have published a genome wide association study, as well as numerous investigations into candidate genes.  Epigenomic DNA methylation analysis and gene expression analysis of 3500 individuals is currently ongoing. 

Education and Training

  • Ph.D., Johns Hopkins University, 1990

Publications

Geisert, Eldon E., Felix L. Struebing, Rebecca King, Louis R. Pasquale, Allison E. Ashley-Koch, Michael A. Hauser, R Rand Allingham, and Janey L. Wiggs. “GENOMIC LOCI MODULATING GANGLION CELL DEATH FOLLOWING ELEVATED IOP IN THE MOUSE.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.

Scholars@Duke

Hauser, Michael A., Ching-Yu Cheng, R Rand Allingham, Tin Aung, Yih-Chung Tham, Eranga Nishanthie Vithana, Chiea Chuen Khor, and Tien Yin Wong. “A common, protein-coding variant of SIX6 is associated with reduced retinal nerve fiber layer thickness.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.

Scholars@Duke

Aboobakar, Inas F., Jin Liang, Michael A. Hauser, R Rand Allingham, and W Daniel Stamer. “Cyclic mechanical stress alters LOXL1 gene expression in trabecular meshwork and Schlemm's canal cells.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.

Scholars@Duke

Kang, Jae H., Hugues Aschard, Michael A. Hauser, Jonathan L. Haines, William Gerard Christen, Peter Kraft, Daniel Ian Chasman, Jessica Cooke Bailey, Janey L. Wiggs, and Louis R. Pasquale. “Age at menopause genetic risk score in relation to primary open-angle glaucoma in the Augmented GLAUGEN study.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.

Scholars@Duke

Aung, Tin, Mineo Ozaki, Takanori Mizoguchi, R Rand Allingham, Zheng Li, Aravind Haripriya, Satoko Nakano, et al. “Corrigendum: a common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.” Nat Genet, June 2015. https://doi.org/10.1038/ng0615-689c.

PMID
26018902
Full Text

King, Rebecca, Michael A. Hauser, Louis R. Pasquale, Janey L. Wiggs, Allison E. Ashley-Koch, R Rand Allingham, and Eldon E. Geisert. “Mouse Genomic Loci Modulating Corneal Thickness.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.

Scholars@Duke

Liu, Yutao, Khaled Abu-Amero, Yelena Bykhovskaya, Arthur Zimmerman, Abdulrahman Al-Muammar, Xiaohui Li, Jerome I. Rotter, R Rand Allingham, Michael A. Hauser, and Yaron S. Rabinowitz. “The Role of Rare Coding Variants in Keratoconus-associated Candidate Genes using Exome Sequencing.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.

Scholars@Duke

Helwa, Inas, Khaled Abu-Amero, Abdulrahman Al-Muammar, Shelby Strickland, Michael A. Hauser, R Rand Allingham Allingham, and Yutao Liu. “Association between CCT-associated variants and keratoconus in a Saudi Arabian population.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.

Scholars@Duke

Reddy, Varun, Sharon Freedman, Shelby Strickland, Yu Chen-Hsin, Rachel W. Kuchtey, John Kuchtey, R Rand Allingham, and Michael A. Hauser. “In search of novel CYP1B1 mutations that cause primary congenital glaucoma.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.

Scholars@Duke

Struebing, Felix L., Rebecca King, Allison Ashley-Koch, Michael A. Hauser, R Rand Allingham, and Eldon E. Geisert. “Interval mapping reveals a quantitative trait locus controlling retinal ganglion cell number in mice.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.

Scholars@Duke

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