Michael Linn Russell, MD

Professor Emeritus of Medicine
Campus mail 1813 Country Lane, Durham, NC 27713
Phone (919) 818-8495
Email address michael.russell@duke.edu

The primary focus of my research is reactive gas dosimetry. The main body of work has involved using O-labeled nitrogen oxide to perform dosimetric analysis on rodents. O is a radioistope with a half-life of 2.04 minutes produced in the DUMC cyclotron. This N1502 is expoed to mice, rats guinea pigs and hamsters, either free breathing or on mechanical ventilation. A number of bronchoalveolar lavage studies have been performed demonstrating the high solubility of radiolabeled N02 in the aqueous but not lipid fraction of lung tissue. the distribution of N 1502 uptake throughout the entire respiratory tract has been mapped. Similar studies will be performed using )-labeled ozone. Additional studies have been performed using phosgene, which is a highly reactive chamical intermediate used in industry. Microdissection of lung tissue at the junction between the bronchial and the alveolar region demonstrated that this gas produced a toxic thickening in the epithelium, in the most proximal regions of the alveolar regions. This effect dissipated as the gas moved distally. This indicates that the highly reactive gas was taken up in the proximal regions leaving a lower concentration in the distal regions. This affect is magnified by the fact that the surface area of the alveolar region increases moving distally. Furture work will involve looking at injury in the alveolar region induced by inhaled particles and dosimetry of inhaled particles throughout the respiratory tract

Education and Training

  • Pulmonary Fellow, Medicine, Duke University, 1988 - 1990
  • Medical Resident, Medicine, Duke University, 1985 - 1988
  • M.D., University of North Carolina at Chapel Hill, 1985

Publications

Lobach, D. F., K. Kawamoto, K. J. Anstrom, M. L. Russell, P. Woods, and D. Smith. “Development, deployment and usability of a point-of-care decision support system for chronic disease management using the recently-approved HL7 decision support service standard.” Studies in Health Technology and Informatics 129 (December 1, 2007): 861–65.

Scholars@Duke

Vlahovic, G., M. L. Russell, R. R. Mercer, and J. D. Crapo. “Cellular and connective tissue changes in alveolar septal walls in emphysema..” Am J Respir Crit Care Med 160, no. 6 (December 1999): 2086–92. https://doi.org/10.1164/ajrccm.160.6.9706031.

PMID
10588633
Full Text

Dunn, W. L., M. L. Russell, B. W. Wieland, and A. M. Yacout. “Monte Carlo analysis of multi-layer targets for production of 15O..” Appl Radiat Isot 48, no. 10–12 (October 1997): 1591–1600. https://doi.org/10.1016/s0969-8043(97)00260-1.

PMID
9463879
Full Text