Mustafa Khasraw, MD

Professor of Neurosurgery
Professor in Medicine
Member of the Duke Cancer Institute
Email address mustafa.khasraw@duke.edu

I am a medical oncologist, neuro-oncologist, and Deputy Director of the Center for Cancer Immunotherapy, Duke Cancer Institute, where are tasked to speed up clinical research and translation for scientists across all departments and all tumor types at Duke, who have made discoveries that show promise for developing new immunotherapies.

I am leading several clinical and translational programs with significant laboratory collaborations with an interest in innovative trials designed to improve the outcome of patients with cancers of the CNS. In addition, I am the principal investigator on first in human phase I immunotherapy clinical trials in solid tumors. 

I serve as an advisor and grant reviewer for several non-profits and patient advocacy groups. I am a Fellow of the Royal Australasian College of Physicians and an Elected Fellow of the Royal College of Physicians ( UK). 

Education and Training

  • M.D., Rijksuniversiteit Groningen (The Netherlands), 2001

Publications

McGrail, D. J., P. G. Pilié, N. U. Rashid, L. Voorwerk, M. Slagter, M. Kok, E. Jonasch, et al. “Reply to: 'Real-world prevalence across 159 872 patients with cancer supports the clinical utility of TMB-H to define metastatic solid tumors for treatment with pembrolizumab.' by D. Fabrizio et al.” Ann Oncol 32, no. 9 (September 2021): 1194–97. https://doi.org/10.1016/j.annonc.2021.06.017.

PMID
34166757
Full Text

Najem, Hinda, Mustafa Khasraw, and Amy B. Heimberger. “Immune Microenvironment Landscape in CNS Tumors and Role in Responses to Immunotherapy.” Cells 10, no. 8 (August 9, 2021). https://doi.org/10.3390/cells10082032.

PMID
34440802
Full Text

Lee, Eudocia Q., Wendy Selig, Clair Meehan, Jeffrey Bacha, Amy Barone, Erik Bloomquist, Susan M. Chang, et al. “Report of National Brain Tumor Society roundtable workshop on innovating brain tumor clinical trials: building on lessons learned from COVID-19 experience.” Neuro Oncol 23, no. 8 (August 2, 2021): 1252–60. https://doi.org/10.1093/neuonc/noab082.

PMID
33822177
Full Text

Isaacs, James, Aaron C. Tan, Brent A. Hanks, Xiaofei Wang, Kouros Owzar, James E. Herndon, Scott J. Antonia, Steven Piantadosi, and Mustafa Khasraw. “Clinical Trials with Biologic Primary Endpoints in Immuno-oncology: Concepts and Usage.” Clin Cancer Res, July 26, 2021. https://doi.org/10.1158/1078-0432.CCR-21-1593.

PMID
34312214
Full Text

Tan, Aaron C., Stephen J. Bagley, Patrick Y. Wen, Michael Lim, Michael Platten, Howard Colman, David M. Ashley, et al. “Systematic review of combinations of targeted or immunotherapy in advanced solid tumors.” J Immunother Cancer 9, no. 7 (July 2021). https://doi.org/10.1136/jitc-2021-002459.

PMID
34215688
Full Text

Kong, Benjamin Y., Candace Carter, Anna K. Nowak, Elizabeth Hovey, Zarnie Lwin, Neda Haghighi, Hui K. Gan, et al. “Barriers and potential solutions to international collaboration in neuro-oncology clinical trials: Challenges from the Australian perspective.” Asia Pac J Clin Oncol, June 24, 2021. https://doi.org/10.1111/ajco.13606.

PMID
34166569
Full Text

Thompson, Eric, Daniel Landi, Gerald Archer, Eric Lipp, Ashley Walter, Bridget Archambault, Bea Balajonda, et al. “EPCT-01. A NOVEL PEPTIDE VACCINE DIRECTED TO CMV PP65 FOR TREATMENT OF RECURRENT MALIGNANT GLIOMA AND MEDULLOBLASTOMA IN CHILDREN AND YOUNG ADULTS: PRELIMINARY RESULTS OF A PHASE I TRIAL.” In Neuro Oncology, 23:i46–i46. Oxford University Press (OUP), 2021. https://doi.org/10.1093/neuonc/noab090.187.

Full Text

Venugopal, Abhirami, Jessie Gillick-Walker, Agnes Michalczyk, Mustafa Khasraw, and M Leigh Ackland. “mRNA profiling of a well-differentiated G1 pancreatic NET correlates with immunohistochemistry profile: a case report.” Bmc Gastroenterol 21, no. 1 (April 27, 2021): 194. https://doi.org/10.1186/s12876-021-01705-9.

PMID
33906633
Full Text

Taylor, Amelia M., David Lok Hang Chan, Martin Tio, Sujata M. Patil, Tiffany A. Traina, Mark E. Robson, and Mustafa Khasraw. “PARP (Poly ADP-Ribose Polymerase) inhibitors for locally advanced or metastatic breast cancer.” Cochrane Database Syst Rev 4 (April 22, 2021): CD011395. https://doi.org/10.1002/14651858.CD011395.pub2.

PMID
33886122
Full Text

Srinivasan, Ethan S., Aaron C. Tan, Carey K. Anders, Ann Marie Pendergast, Dorothy A. Sipkins, David M. Ashley, Peter E. Fecci, and Mustafa Khasraw. “Salting the Soil: Targeting the Microenvironment of Brain Metastases.” Mol Cancer Ther 20, no. 3 (March 2021): 455–66. https://doi.org/10.1158/1535-7163.MCT-20-0579.

PMID
33402399
Full Text

Pages