Nancy Bates Allen, MD

Professor Emeritus of Medicine
Campus mail 4010 Purple Zone Hosp South, 201 Trent Dr., Durham, NC 27710
Phone (919) 684-2965
Email address nancy.allen@duke.edu

My clinical research interests include systemic vasculitis (Wegener's granulomatosis, microscopic polyangiitis, giant cell arteritis, Takayasu arteritis) and multi-disciplinary efforts in the areas of systemic lupus erythematosus and anti-phospholipid syndrome. Dr. E. William St. Clair and I represented Duke in both the RAVE trial, a multi-center, double-blind, controlled trial comparing rituximab with cyclophosphamide in patients with ANCA-associated vasculitis and previously the Wegener's granulomatosis etanercept trial (WGET), a multi-center effort to assess the addition of etanercept to traditional therapy in limited and severe forms of this type of vasculitis.

My area of clinical expertise is in the care of patients with all types of vasculitis, particularly Granulomatosis with Polyangiitis (formerly called Wegener's granulomatosis), Micropscopic Polyangiitis, other ANCA-associated vasculitides, giant cell arteritis, and Takayasu's arteritis. I also care for patients with systemic lupus erythematosus, anti-phospholipid syndrome, and women's health-related rheumatologic diseases. In addition I see all patients and educate trainees about all types of rheumatologic and arthritis conditions. Key words: vasculitis, systemic vasculitis, Wegener's granulomatosis, giant cell (temporal) arteritis, Takayasu arteritis, anti-phospholipid antibody syndrome.

Education and Training

  • Rheumatology Fellow, Medicine, Duke University, 1981 - 1983
  • Medical Resident, Medicine, Duke University, 1978 - 1979
  • M.D., Tufts University, 1978

Publications

Sebastian, J. K., B. Voetsch, J. H. Stone, Z. Romay-Penabad, G. H. Lo, N. B. Allen, J. C. Davis, et al. “The frequency of anticardiolipin antibodies and genetic hypercoagulable factors among patients with Wegener's granulomatosis with and without a history of a thrombotic event.” In Arthritis and Rheumatism, 54:S496–97. WILEY-LISS, 2006.

Scholars@Duke

Stone, John H., Janet T. Holbrook, Matthew A. Marriott, Andrea K. Tibbs, Lourdes P. Sejismundo, Y. -. I. Min, Ulrich Specks, et al. “Solid malignancies among patients in the Wegener's Granulomatosis Etanercept Trial.” Arthritis Rheum 54, no. 5 (May 2006): 1608–18. https://doi.org/10.1002/art.21869.

PMID
16646004
Full Text

Wung, Peter K., Janet T. Holbrook, Gary S. Hoffman, Andrea K. Tibbs, Ulrich Specks, Y. -. I. Min, Peter A. Merkel, et al. “Herpes zoster in immunocompromised patients: incidence, timing, and risk factors.” Am J Med 118, no. 12 (December 2005): 1416. https://doi.org/10.1016/j.amjmed.2005.06.012.

PMID
16378799
Full Text

Wung, P. K., J. T. Holbrook, G. S. Hoffman, A. K. Tibbs, U. Specks, Y. I. Min, P. A. Merkel, et al. “Risk factors for herpes zoster in immunocompromised patients: Experience from the Wegener's granulomatosis etanercept trial.” In Arthritis and Rheumatism, 52:S648–49. WILEY-BLACKWELL, 2005.

Scholars@Duke

Stone, J. H., J. T. Holbrook, M. A. Marriott, A. K. Tibbs, L. P. Sejismundo, Y. I. Min, U. Specks, et al. “Solid malignancies among Wegener's granulomatosis patients treated with etanercept: Potential interaction with cyclophosphamide.” In Arthritis and Rheumatism, 52:S272–73. WILEY-BLACKWELL, 2005.

Scholars@Duke

Seo, Philip, Yuan-I Min, Janet T. Holbrook, Gary S. Hoffman, Peter A. Merkel, Robert Spiera, John C. Davis, et al. “Damage caused by Wegener's granulomatosis and its treatment: prospective data from the Wegener's Granulomatosis Etanercept Trial (WGET).” Arthritis Rheum 52, no. 7 (July 2005): 2168–78. https://doi.org/10.1002/art.21117.

PMID
15986348
Full Text

Merkel, Peter A., Grace H. Lo, Janet T. Holbrook, Andrea K. Tibbs, Nancy B. Allen, John C. Davis, Gary S. Hoffman, et al. “Brief communication: high incidence of venous thrombotic events among patients with Wegener granulomatosis: the Wegener's Clinical Occurrence of Thrombosis (WeCLOT) Study.” Ann Intern Med 142, no. 8 (April 19, 2005): 620–26. https://doi.org/10.7326/0003-4819-142-8-200505030-00011.

PMID
15838068
Full Text

Merkel, Peter A., Grace H. Lo, Janet T. Holbrook, Andrea K. Tibbs, Nancy B. Allen, John C. Davis, Gary S. Hoffman, et al. “Brief Communication: High Incidence of Venous Thrombotic Events among Patients with Wegener Granulomatosis: The Wegener's Clinical Occurrence of Thrombosis (WeCLOT) Study.” Ann Intern Med 142, no. 8 (April 19, 2005): 620–26. https://doi.org/10.7326/0003-4819-142-8-200504190-00010.

PMID
28501887
Full Text

Wegener’s Granulomatosis Etanercept Trial (WGET) Research Group, Sean M. “Etanercept plus standard therapy for Wegener's granulomatosis.” N Engl J Med 352, no. 4 (January 27, 2005): 351–61. https://doi.org/10.1056/NEJMoa041884.

PMID
15673801
Full Text

Lamprecht, Peter, and Wolfgang L. Gross. “A brief history of Wegener's granulomatosis: on limited, localized, and generalized forms of the disease: comment on the article by the Wegener's Granulomatosis Etanercept Trial Research Group.” Arthritis Rheum 50, no. 1 (January 2004): 334–35. https://doi.org/10.1002/art.11475.

PMID
14730635
Full Text

Pages