Nancy Bates Allen, MD

Professor of Medicine
Campus mail 4140 Purple Zone Hosp South, 201 Trent Dr., Durham, NC 27710
Phone (919) 684-2965
Email address nancy.allen@duke.edu

My clinical research interests include systemic vasculitis (Wegener's granulomatosis, microscopic polyangiitis, giant cell arteritis, Takayasu arteritis) and multi-disciplinary efforts in the areas of systemic lupus erythematosus and anti-phospholipid syndrome. Dr. E. William St. Clair and I represented Duke in both the RAVE trial, a multi-center, double-blind, controlled trial comparing rituximab with cyclophosphamide in patients with ANCA-associated vasculitis and previously the Wegener's granulomatosis etanercept trial (WGET), a multi-center effort to assess the addition of etanercept to traditional therapy in limited and severe forms of this type of vasculitis.

My area of clinical expertise is in the care of patients with all types of vasculitis, particularly Granulomatosis with Polyangiitis (formerly called Wegener's granulomatosis), Micropscopic Polyangiitis, other ANCA-associated vasculitides, giant cell arteritis, and Takayasu's arteritis. I also care for patients with systemic lupus erythematosus, anti-phospholipid syndrome, and women's health-related rheumatologic diseases. In addition I see all patients and educate trainees about all types of rheumatologic and arthritis conditions. Key words: vasculitis, systemic vasculitis, Wegener's granulomatosis, giant cell (temporal) arteritis, Takayasu arteritis, anti-phospholipid antibody syndrome.

Education and Training

  • Rheumatology Fellow, Medicine, Duke University, 1981 - 1983
  • Medical Resident, Medicine, Duke University, 1978 - 1979
  • M.D., Tufts University, 1978

Publications

Stone, JH, Holbrook, JT, Marriott, MA, Tibbs, AK, Sejismundo, LP, Min, Y-I, Specks, U, Merkel, PA, Spiera, R, Davis, JC, St Clair, EW, McCune, WJ, Ytterberg, SR, Allen, NB, Hoffman, GS, and Wegener's Granulomatosis Etanercept Trial Research Group, . "Solid malignancies among patients in the Wegener's Granulomatosis Etanercept Trial." Arthritis Rheum 54, no. 5 (May 2006): 1608-1618.

PMID
16646004
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Wung, PK, Holbrook, JT, Hoffman, GS, Tibbs, AK, Specks, U, Min, Y-I, Merkel, PA, Spiera, R, Davis, JC, St Clair, EW, McCune, J, Ytterberg, SR, Allen, NB, Stone, JH, and WGET Research Group, . "Herpes zoster in immunocompromised patients: incidence, timing, and risk factors." Am J Med 118, no. 12 (December 2005): 1416-.

PMID
16378799
Full Text

Wung, PK, Holbrook, JT, Hoffman, GS, Tibbs, AK, Specks, U, Min, YI, Merkel, PA, Spiera, R, Davis, JC, St Clair, W, McCune, J, Ytterberg, SR, Allen, NB, Stone, JH, and Grp, WGETR. "Risk factors for herpes zoster in immunocompromised patients: Experience from the Wegener's granulomatosis etanercept trial." September 2005.

Scholars@Duke

Stone, JH, Holbrook, JT, Marriott, MA, Tibbs, AK, Sejismundo, LP, Min, YI, Specks, U, Merkel, PA, Spiera, R, Davis, JC, St Clair, EW, McCune, J, Ytterberg, SR, Allen, NB, Hoffman, GS, and Grp, WGETR. "Solid malignancies among Wegener's granulomatosis patients treated with etanercept: Potential interaction with cyclophosphamide." September 2005.

Scholars@Duke

Seo, P, Min, Y-I, Holbrook, JT, Hoffman, GS, Merkel, PA, Spiera, R, Davis, JC, Ytterberg, SR, St Clair, EW, McCune, WJ, Specks, U, Allen, NB, Luqmani, RA, Stone, JH, and WGET Research Group, . "Damage caused by Wegener's granulomatosis and its treatment: prospective data from the Wegener's Granulomatosis Etanercept Trial (WGET)." Arthritis and Rheumatism 52, no. 7 (July 2005): 2168-2178.

PMID
15986348
Full Text

Merkel, PA, Lo, GH, Holbrook, JT, Tibbs, AK, Allen, NB, Davis, JC, Hoffman, GS, McCune, WJ, St Clair, EW, Specks, U, Spiera, R, Petri, M, and Stone, JH. "Brief Communication: High Incidence of Venous Thrombotic Events among Patients with Wegener Granulomatosis: The Wegener's Clinical Occurrence of Thrombosis (WeCLOT) Study." Annals of internal medicine 142, no. 8 (April 2005): 620-626.

PMID
28501887
Full Text

Merkel, PA, Lo, GH, Holbrook, JT, Tibbs, AK, Allen, NB, Davis, JC, Hoffman, GS, McCune, WJ, St Clair, EW, Specks, U, Spiera, R, Petri, M, Stone, JH, and Wegener's Granulomatosis Etanercept Trial Research Group, . "Brief communication: high incidence of venous thrombotic events among patients with Wegener granulomatosis: the Wegener's Clinical Occurrence of Thrombosis (WeCLOT) Study." Annals of Internal Medicine 142, no. 8 (April 2005): 620-626.

PMID
15838068
Full Text

Stone, JH, Hoffman, GS, Holbrook, JT, Meinert, CL, Dodge, J, Donithan, J, Min, N, Murrow, L, Oziemkowska, M, Smith, J, Tibbs, AK, Van Natta, M, Spiera, R, Abeynayake, I, Berman, R, Enuha, S, Merkel, PA, Gelbard, R, Nuite, M, Schiller, A, Hoffman, GS, Blumenthal, D, Bork, D, Clark, T, Crook, SL, Calabrese, LH, Farkas, S, Sridharan, S, Strom, K, Wilke, W, St Clair, EW, Allen, NB, Rodin, K, Scarlett, E, Stone, JH, Hellmann, DB, Marriott, MA, Moore, AM, Pinachos, L, Regan, MJ, and Uhlfelder, ML et al. "Etanercept plus standard therapy for Wegener's granulomatosis." NEW ENGLAND JOURNAL OF MEDICINE 352, no. 4 (January 27, 2005): 351-361.

Scholars@Duke

Lamprecht, P, and Gross, WL. "A brief history of Wegener's granulomatosis: on limited, localized, and generalized forms of the disease: comment on the article by the Wegener's Granulomatosis Etanercept Trial Research Group." Arthritis and rheumatism 50, no. 1 (January 2004): 334-335. (Letter)

PMID
14730635
Full Text

Stone, JH, Holbrook, JT, Tibbs, A, Hoffman, GS, Allen, NB, St Clair, EW, Davis, JC, Merkel, PA, Specks, U, Spiera, RF, and Grp, WGETR. "Validation of a computer version of the American College of Rheumatology Patient Assessment questionnaire for the autonomous self-entry of self-report data in an urban rheumatology clinic - Reply." ARTHRITIS AND RHEUMATISM 50, no. 1 (January 2004): 335-336.

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