Nathan Maclyn Thielman, MD

Professor of Medicine
Research Professor of Global Health
Professor of Pathology
Campus mail 310 Trent Drive, Room 201, Trent Hall, Durham, NC 27710
Phone (919) 668-7174

Broadly, my research focuses on a range of clinical and social issues that affect persons living with or at risk for HIV infection in resource-poor settings. In Tanzania, our group is applying novel methods to optimize HIV testing uptake among high-risk groups. We recently demonstrated that the Discrete Choice Experiment (DCE), a form of stated preference survey research, is a robust tool for identifying (a) which characteristics of HIV testing options are most preferred by different populations and (b) which tradeoffs individuals make in evaluating testing options. Building on more than a decade of productive HIV testing research in the Kilimanjaro Region, the next phase of our NIMH funded project will test the hypothesis that DCE-derived HIV testing options significantly increases rates of testing among groups at high risk for HIV infection. This work holds promise not only for optimizing HIV testing uptake in the Kilimanjaro Region, but also for applying novel tools in the service of translational epidemiology and implementation research.

Education and Training

  • Fellow in Infectious Diseases, Medicine, University of Virginia, 1993 - 1996
  • Medical Resident, Medicine, Duke University, 1990 - 1993
  • M.D., Duke University, 1990
  • M.P.H., University of North Carolina - Chapel Hill, 1989

Publications

Adaken, Charlene, Janet T. Scott, Raman Sharma, Robin Gopal, Steven Dicks, Saidia Niazi, Samreen Ijaz, et al. “Ebola virus antibody decay-stimulation in a high proportion of survivors.” Nature 590, no. 7846 (February 2021): 468–72. https://doi.org/10.1038/s41586-020-03146-y.

PMID
33505020
Full Text

Madut, Deng B., Preeti Manavalan, Antipas Mtalo, Timothy A. Peter, Jan Ostermann, Bernard Njau, and Nathan M. Thielman. “Increasing the Uptake of HIV Testing among Men in Tanzania: A Novel Intervention for Bar Patrons.” Aids Behav, January 3, 2021. https://doi.org/10.1007/s10461-020-03131-6.

PMID
33389376
Full Text

Ostermann, Jan, Bernard Njau, Amy Hobbie, Tara Mtuy, Martha L. Masaki, Aisa Shayo, Marco van Zwetselaar, et al. “Using discrete choice experiments to design interventions for heterogeneous preferences: protocol for a pragmatic randomised controlled trial of a preference-informed, heterogeneity-focused, HIV testing offer for high-risk populations.” Bmj Open 10, no. 11 (November 6, 2020): e039313. https://doi.org/10.1136/bmjopen-2020-039313.

PMID
33158826
Full Text

Hertz, Julian T., Francis M. Sakita, Godfrey L. Kweka, Gerald S. Bloomfield, John A. Bartlett, Tumsifu G. Tarimo, Gloria Temu, Janet P. Bettger, and Nathan M. Thielman. “Effect of a Triage-Based Screening Protocol on Diagnosis and Treatment of Acute Coronary Syndrome in a Tanzanian Emergency Department: A Prospective Pre-Post Study.” J Am Heart Assoc 9, no. 16 (August 18, 2020): e016501. https://doi.org/10.1161/JAHA.120.016501.

PMID
32772764
Full Text

Hertz, Julian T., Francis M. Sakita, Godfrey L. Kweka, Alexander T. Limkakeng, Sophie W. Galson, Jinny J. Ye, Tumsifu G. Tarimo, et al. “Acute myocardial infarction under-diagnosis and mortality in a Tanzanian emergency department: A prospective observational study.” Am Heart J 226 (August 2020): 214–21. https://doi.org/10.1016/j.ahj.2020.05.017.

PMID
32619815
Full Text

Manavalan, Preeti, Deng B. Madut, Julian T. Hertz, Nathan M. Thielman, Nwora Lance Okeke, Blandina T. Mmbaga, and Melissa H. Watt. “Hypertension burden and challenges across the hypertension treatment cascade among adults enrolled in HIV care in northern Tanzania.” J Clin Hypertens (Greenwich) 22, no. 8 (August 2020): 1518–22. https://doi.org/10.1111/jch.13929.

PMID
32652868
Full Text

Ostermann, Jan, Axel Mühlbacher, Derek S. Brown, Dean A. Regier, Amy Hobbie, Andrew Weinhold, Noor Alshareef, Caroline Derrick, and Nathan M. Thielman. “Heterogeneous Patient Preferences for Modern Antiretroviral Therapy: Results of a Discrete Choice Experiment.” Value Health 23, no. 7 (July 2020): 851–61. https://doi.org/10.1016/j.jval.2020.03.007.

PMID
32762986
Full Text

McCrary, Andrew W., Winstone M. Nyandiko, Alicia M. Ellis, Hrishikesh Chakraborty, Michael J. Muehlbauer, Myra M. Koech, Ibrahim Daud, et al. “Early cardiac dysfunction in children and young adults with perinatally acquired HIV.” Aids 34, no. 4 (March 15, 2020): 539–48. https://doi.org/10.1097/QAD.0000000000002445.

PMID
31794518
Full Text

Madut, Deng B., Lawrence P. Park, Jia Yao, Elizabeth A. Reddy, Bernard Njau, Jan Ostermann, Kathryn Whetten, and Nathan M. Thielman. “Predictors of mortality in treatment experienced HIV-infected patients in northern Tanzania.” Plos One 15, no. 10 (2020): e0240293. https://doi.org/10.1371/journal.pone.0240293.

PMID
33031434
Full Text

Manavalan, Preeti, Linda Minja, Lisa Wanda, Julian T. Hertz, Nathan M. Thielman, Nwora Lance Okeke, Blandina T. Mmbaga, and Melissa H. Watt. “"It's because I think too much": Perspectives and experiences of adults with hypertension engaged in HIV care in northern Tanzania.” Plos One 15, no. 12 (2020): e0243059. https://doi.org/10.1371/journal.pone.0243059.

PMID
33270765
Full Text

Pages