Neil Ross MacIntyre, MD

Professor of Medicine
Campus mail 1120 Hosp North, Durham, NC 27710
Phone (919) 681-2720
Email address macin001@mc.duke.edu

1) Mechanical Ventilation and respiratory failure. Current projects involve studying patient-ventilator interactions during modes of support that require patient activity. The focus is on ventilatory muscle function during these assisted modes. Other projects include evaluating respiratory system mechanics in acute respiratory failure and the role of ECMO in the adult. Duke is also one of several institutions in the NIH ARDS Network, a consortium designed to perform multi-center trials.

2) Diffusing capacity of the lung for carbon monoxide. Current projects involve using a rapidly responding gas analyzer to measure lung diffusing capacity in discrete regions of the lung. These analyses are being extended into mechanically ventilated patients.

3) COPD. Current projects involve studying the physiology of cardio-respiratory conditioning in patients with obstructive lung disease and the role of pulmonary rehabilitation in improving COPD outcomes. Duke is also a member of two NIH sponsored multicenter programs: the COPDgene project correlating genetic profiles with physiologic/clinical phenotypes; and the NIH LOTT project evaluating the role of oxygen therapy in exercise and sleep hypoxemia.

4) Aerosol delivery systems. The current project is the development of a prototype aerosol generating catheter that can be directly inserted into the airways. Studies are being conducted in both ex vivo animal lungs and in mechanically ventilated patients.

Education and Training

  • M.D., Cornell University, 1972

Publications

Macintyre, NR, and Fink, JB. "Discussion." Respiratory Care 60, no. 6 (January 1, 2015): 771-773.

Scholars@Duke

Miller, AG, Cappiello, JL, Gentile, MA, Almond, AM, Thalman, JJ, and MacIntyre, NR. "Analysis of radial artery catheter placement by respiratory therapists using ultrasound guidance." Respiratory care 59, no. 12 (December 2014): 1813-1816.

PMID
25233385
Full Text

Holland, AE, Spruit, MA, Troosters, T, Puhan, MA, Pepin, V, Saey, D, McCormack, MC, Carlin, BW, Sciurba, FC, Pitta, F, Wanger, J, MacIntyre, N, Kaminsky, DA, Culver, BH, Revill, SM, Hernandes, NA, Andrianopoulos, V, Camillo, CA, Mitchell, KE, Lee, AL, Hill, CJ, and Singh, SJ. "An official European Respiratory Society/American Thoracic Society technical standard: field walking tests in chronic respiratory disease." The European respiratory journal 44, no. 6 (December 2014): 1428-1446. (Review)

PMID
25359355
Full Text

Singh, SJ, Puhan, MA, Andrianopoulos, V, Hernandes, NA, Mitchell, KE, Hill, CJ, Lee, AL, Camillo, CA, Troosters, T, Spruit, MA, Carlin, BW, Wanger, J, Pepin, V, Saey, D, Pitta, F, Kaminsky, DA, McCormack, MC, MacIntyre, N, Culver, BH, Sciurba, FC, Revill, SM, Delafosse, V, and Holland, AE. "An official systematic review of the European Respiratory Society/American Thoracic Society: measurement properties of field walking tests in chronic respiratory disease." The European respiratory journal 44, no. 6 (December 2014): 1447-1478. (Review)

PMID
25359356
Full Text

McDonald, M-LN, Cho, MH, Sørheim, I-C, Lutz, SM, Castaldi, PJ, Lomas, DA, Coxson, HO, Edwards, LD, MacNee, W, Vestbo, J, Yates, JC, Agusti, A, Calverley, PMA, Celli, B, Crim, C, Rennard, SI, Wouters, EFM, Bakke, P, Tal-Singer, R, Miller, BE, Gulsvik, A, Casaburi, R, Wells, JM, Regan, EA, Make, BJ, Hokanson, JE, Lange, C, Crapo, JD, Beaty, TH, Silverman, EK, Hersh, CP, and Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints and COPDGene Investigators, . "Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease." American Journal of Respiratory Cell and Molecular Biology 51, no. 5 (November 2014): 678-687.

PMID
24825563
Full Text

Hobbs, BD, Foreman, MG, Bowler, R, Jacobson, F, Make, BJ, Castaldi, PJ, San José Estépar, R, Silverman, EK, Hersh, CP, and COPDGene Investigators, . "Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease." Annals of the American Thoracic Society 11, no. 9 (November 2014): 1387-1394.

PMID
25295410
Full Text

Hersh, CP, Make, BJ, Lynch, DA, Barr, RG, Bowler, RP, Calverley, PMA, Castaldi, PJ, Cho, MH, Coxson, HO, DeMeo, DL, Foreman, MG, Han, MK, Harshfield, BJ, Hokanson, JE, Lutz, S, Ramsdell, JW, Regan, EA, Rennard, SI, Schroeder, JD, Sciurba, FC, Steiner, RM, Tal-Singer, R, van Beek, E, Silverman, EK, Crapo, JD, and COPDGene and ECLIPSE Investigators, . "Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus." Bmc Pulmonary Medicine 14 (October 24, 2014): 164-null.

PMID
25341556
Full Text

MacIntyre, NR. "Tissue hypoxia: implications for the respiratory clinician." Respiratory care 59, no. 10 (October 2014): 1590-1596. (Review)

PMID
25161296
Full Text

Bowler, RP, Kim, V, Regan, E, Williams, AAA, Santorico, SA, Make, BJ, Lynch, DA, Hokanson, JE, Washko, GR, Bercz, P, Soler, X, Marchetti, N, Criner, GJ, Ramsdell, J, Han, MK, Demeo, D, Anzueto, A, Comellas, A, Crapo, JD, Dransfield, M, Wells, JM, Hersh, CP, MacIntyre, N, Martinez, F, Nath, HP, Niewoehner, D, Sciurba, F, Sharafkhaneh, A, Silverman, EK, van Beek, EJR, Wilson, C, Wendt, C, and Wise, RA. "Prediction of acute respiratory disease in current and former smokers with and without COPD." Chest 146, no. 4 (October 2014): 941-950.

PMID
24945159
Full Text

Sottile, PD, Moss, M, Patel, JJ, Truwit, JD, Sheikh, M, Zimmerman, JL, Diwakar, A, Schmidt, GA, Means, GT, Katz, JN, Desai, AS, MacIntyre, NR, and Poston, JT. "ATS Core Curriculum 2014: Part II. Adult critical care medicine." Annals of the American Thoracic Society 11, no. 8 (October 2014): 1307-1315. (Review)

PMID
25343197
Full Text

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