Neil Ross MacIntyre, MD

Professor of Medicine
Campus mail 1120 Hosp North, Durham, NC 27710
Phone (919) 681-2720
Email address macin001@mc.duke.edu

1) Mechanical Ventilation and respiratory failure. Current projects involve studying patient-ventilator interactions during modes of support that require patient activity. The focus is on ventilatory muscle function during these assisted modes. Other projects include evaluating respiratory system mechanics in acute respiratory failure and the role of ECMO in the adult. Duke is also one of several institutions in the NIH ARDS Network, a consortium designed to perform multi-center trials.

2) Diffusing capacity of the lung for carbon monoxide. Current projects involve using a rapidly responding gas analyzer to measure lung diffusing capacity in discrete regions of the lung. These analyses are being extended into mechanically ventilated patients.

3) COPD. Current projects involve studying the physiology of cardio-respiratory conditioning in patients with obstructive lung disease and the role of pulmonary rehabilitation in improving COPD outcomes. Duke is also a member of two NIH sponsored multicenter programs: the COPDgene project correlating genetic profiles with physiologic/clinical phenotypes; and the NIH LOTT project evaluating the role of oxygen therapy in exercise and sleep hypoxemia.

4) Aerosol delivery systems. The current project is the development of a prototype aerosol generating catheter that can be directly inserted into the airways. Studies are being conducted in both ex vivo animal lungs and in mechanically ventilated patients.

Education and Training

  • M.D., Cornell University, 1972

Publications

Macintyre, N. R., and J. B. Fink. “Discussion.” Respiratory Care 60, no. 6 (January 1, 2015): 847–49.

Scholars@Duke

Schell-Chaple, Hildy M., Kathleen A. Puntillo, Michael A. Matthay, Kathleen D. Liu, and Kathleen D. National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network. “Body temperature and mortality in patients with acute respiratory distress syndrome..” Am J Crit Care 24, no. 1 (January 2015): 15–23. https://doi.org/10.4037/ajcc2015320.

PMID
25554550
Full Text

Fink, J. B., and N. R. Macintyre. “Discussion.” Respiratory Care 60, no. 6 (January 1, 2015): 874–79.

Scholars@Duke

Suggett, J. A., J. B. Fink, and N. R. Macintyre. “Discussion.” Respiratory Care 60, no. 6 (January 1, 2015): 830–32.

Scholars@Duke

Miller, Andrew G., Jhaymie L. Cappiello, Michael A. Gentile, Andrew M. Almond, Janice J. Thalman, and Neil R. MacIntyre. “Analysis of radial artery catheter placement by respiratory therapists using ultrasound guidance..” Respir Care 59, no. 12 (December 2014): 1813–16. https://doi.org/10.4187/respcare.02905.

PMID
25233385
Full Text

Holland, Anne E., Martijn A. Spruit, Thierry Troosters, Milo A. Puhan, Véronique Pepin, Didier Saey, Meredith C. McCormack, et al. “An official European Respiratory Society/American Thoracic Society technical standard: field walking tests in chronic respiratory disease..” Eur Respir J 44, no. 6 (December 2014): 1428–46. https://doi.org/10.1183/09031936.00150314.

PMID
25359355
Full Text

Singh, Sally J., Milo A. Puhan, Vasileios Andrianopoulos, Nidia A. Hernandes, Katy E. Mitchell, Catherine J. Hill, Annemarie L. Lee, et al. “An official systematic review of the European Respiratory Society/American Thoracic Society: measurement properties of field walking tests in chronic respiratory disease..” Eur Respir J 44, no. 6 (December 2014): 1447–78. https://doi.org/10.1183/09031936.00150414.

PMID
25359356
Full Text

McDonald, Merry-Lynn N., Michael H. Cho, Inga-Cecilie Sørheim, Sharon M. Lutz, Peter J. Castaldi, David A. Lomas, Harvey O. Coxson, et al. “Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease..” Am J Respir Cell Mol Biol 51, no. 5 (November 2014): 678–87. https://doi.org/10.1165/rcmb.2014-0135OC.

PMID
24825563
Full Text

Hobbs, Brian D., Marilyn G. Foreman, Russell Bowler, Francine Jacobson, Barry J. Make, Peter J. Castaldi, Raúl San José Estépar, Edwin K. Silverman, Craig P. Hersh, and Craig P. COPDGene Investigators. “Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease..” Ann Am Thorac Soc 11, no. 9 (November 2014): 1387–94. https://doi.org/10.1513/AnnalsATS.201405-224OC.

PMID
25295410
Full Text

Hersh, Craig P., Barry J. Make, David A. Lynch, R Graham Barr, Russell P. Bowler, Peter M. A. Calverley, Peter J. Castaldi, et al. “Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus..” Bmc Pulm Med 14 (October 24, 2014). https://doi.org/10.1186/1471-2466-14-164.

PMID
25341556
Full Text

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