Neil Ross MacIntyre, MD

Professor of Medicine
Campus mail 1120 Hosp North, Durham, NC 27710
Phone (919) 681-2720
Email address macin001@mc.duke.edu

1) Mechanical Ventilation and respiratory failure. Current projects involve studying patient-ventilator interactions during modes of support that require patient activity. The focus is on ventilatory muscle function during these assisted modes. Other projects include evaluating respiratory system mechanics in acute respiratory failure and the role of ECMO in the adult. Duke is also one of several institutions in the NIH ARDS Network, a consortium designed to perform multi-center trials.

2) Diffusing capacity of the lung for carbon monoxide. Current projects involve using a rapidly responding gas analyzer to measure lung diffusing capacity in discrete regions of the lung. These analyses are being extended into mechanically ventilated patients.

3) COPD. Current projects involve studying the physiology of cardio-respiratory conditioning in patients with obstructive lung disease and the role of pulmonary rehabilitation in improving COPD outcomes. Duke is also a member of two NIH sponsored multicenter programs: the COPDgene project correlating genetic profiles with physiologic/clinical phenotypes; and the NIH LOTT project evaluating the role of oxygen therapy in exercise and sleep hypoxemia.

4) Aerosol delivery systems. The current project is the development of a prototype aerosol generating catheter that can be directly inserted into the airways. Studies are being conducted in both ex vivo animal lungs and in mechanically ventilated patients.

Education and Training

  • M.D., Cornell University, 1972

Publications

Lee, Jin Hwa, Michael H. Cho, Craig P. Hersh, Merry-Lynn N. McDonald, James D. Crapo, Per S. Bakke, Amund Gulsvik, et al. “Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease..” Respiratory Research 15 (September 21, 2014). https://doi.org/10.1186/s12931-014-0113-2.

PMID
25241909
Full Text

Lee, Jin Hwa, Merry-Lynn N. McDonald, Michael H. Cho, Emily S. Wan, Peter J. Castaldi, Gary M. Hunninghake, Nathaniel Marchetti, et al. “DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease..” Respiratory Research 15 (August 20, 2014). https://doi.org/10.1186/s12931-014-0097-y.

PMID
25134640
Full Text

Wan, E. S., P. J. Castaldi, M. H. Cho, J. E. Hokanson, E. A. Regan, B. J. Make, T. H. Beaty, et al. “Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene.” Respiratory Research 15, no. 1 (August 6, 2014). https://doi.org/10.1186/s12931-014-0089-y.

Full Text

Wan, Emily S., Peter J. Castaldi, Michael H. Cho, John E. Hokanson, Elizabeth A. Regan, Barry J. Make, Terri H. Beaty, et al. “Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene..” Respiratory Research 15 (August 6, 2014). https://doi.org/10.1186/s12931-014-0089-y.

PMID
25096860
Full Text

Pathak, Vikas, Ian Welsby, Kamran Mahmood, Momen Wahidi, Neil MacIntyre, and Scott Shofer. “Ventilation and anesthetic approaches for rigid bronchoscopy..” Annals of the American Thoracic Society 11, no. 4 (May 2014): 628–34. https://doi.org/10.1513/annalsats.201309-302fr.

PMID
24635585
Full Text

Kim, Victor, Adam Davey, Alejandro P. Comellas, Meilan K. Han, George Washko, Carlos H. Martinez, David Lynch, et al. “Clinical and computed tomographic predictors of chronic bronchitis in COPD: a cross sectional analysis of the COPDGene study..” Respiratory Research 15 (April 27, 2014). https://doi.org/10.1186/1465-9921-15-52.

PMID
24766722
Full Text

Kim, V., A. Davey, A. P. Comellas, M. K. Han, G. Washko, C. H. Martinez, D. Lynch, et al. “Clinical and computed tomographic predictors of chronic bronchitis in COPD: A cross sectional analysis of the COPDGene study.” Respiratory Research 15, no. 1 (April 27, 2014). https://doi.org/10.1186/1465-9921-15-52.

Full Text

Cho, Michael H., Merry-Lynn N. McDonald, Xiaobo Zhou, Manuel Mattheisen, Peter J. Castaldi, Craig P. Hersh, Dawn L. Demeo, et al. “Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis..” The Lancet. Respiratory Medicine 2, no. 3 (March 2014): 214–25. https://doi.org/10.1016/S2213-2600(14)70002-5.

PMID
24621683
Full Text

Swigris, Jeffrey J., David L. Streiner, Kevin K. Brown, Amanda Belkin, Kathy E. Green, Frederick S. Wamboldt, and Frederick S. IPFnet Investigators. “Assessing exertional dyspnea in patients with idiopathic pulmonary fibrosis..” Respiratory Medicine 108, no. 1 (January 2014): 181–88. https://doi.org/10.1016/j.rmed.2013.12.009.

PMID
24388667
Full Text

Matthay, M. A., R. G. Brower, S. Carson, I. S. Douglas, M. Eisner, D. Hite, S. Holets, R. H. Kallet, K. D. Liu, and N. MacIntyre. “Erratum: Randomized, placebo-controlled clinical trial of an aerosolized β2-agonist for treatment of acute lung injury (American Journal of Respiratory and Critical Care Medicine (2011) 184 (561-568)).” American Journal of Respiratory and Critical Care Medicine 188, no. 11 (December 1, 2013).

Scholars@Duke

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