Neil Ross MacIntyre, MD

Professor of Medicine
Campus mail 1120 Hosp North, Durham, NC 27710
Phone (919) 681-2720
Email address macin001@mc.duke.edu

1) Mechanical Ventilation and respiratory failure. Current projects involve studying patient-ventilator interactions during modes of support that require patient activity. The focus is on ventilatory muscle function during these assisted modes. Other projects include evaluating respiratory system mechanics in acute respiratory failure and the role of ECMO in the adult. Duke is also one of several institutions in the NIH ARDS Network, a consortium designed to perform multi-center trials.

2) Diffusing capacity of the lung for carbon monoxide. Current projects involve using a rapidly responding gas analyzer to measure lung diffusing capacity in discrete regions of the lung. These analyses are being extended into mechanically ventilated patients.

3) COPD. Current projects involve studying the physiology of cardio-respiratory conditioning in patients with obstructive lung disease and the role of pulmonary rehabilitation in improving COPD outcomes. Duke is also a member of two NIH sponsored multicenter programs: the COPDgene project correlating genetic profiles with physiologic/clinical phenotypes; and the NIH LOTT project evaluating the role of oxygen therapy in exercise and sleep hypoxemia.

4) Aerosol delivery systems. The current project is the development of a prototype aerosol generating catheter that can be directly inserted into the airways. Studies are being conducted in both ex vivo animal lungs and in mechanically ventilated patients.

Education and Training

  • M.D., Cornell University, 1972

Publications

Miller, RR, MacIntyre, NR, Hite, RD, Truwit, JD, Brower, RG, and Morris, AH. "Point: should positive end-expiratory pressure in patients with ARDS be set on oxygenation? Yes." Chest 141, no. 6 (June 2012): 1379-1382.

PMID
22670017
Full Text

Martinez, CH, Chen, Y-H, Westgate, PM, Liu, LX, Murray, S, Curtis, JL, Make, BJ, Kazerooni, EA, Lynch, DA, Marchetti, N, Washko, GR, Martinez, FJ, Han, MK, and COPDGene Investigators, . "Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease." Thorax 67, no. 5 (May 2012): 399-406.

PMID
22514236
Full Text

Rambod, M, Porszasz, J, Make, BJ, Crapo, JD, Casaburi, R, and COPDGene Investigators, . "Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort." Chest 141, no. 4 (April 2012): 867-875.

PMID
21960696
Full Text

Hegewald, MJ, Jensen, RL, Teeter, JG, Wise, RA, Riese, RJ, England, RD, Ahrens, RC, Crapo, RO, and MacIntyre, NR. "Long-term intersession variability for single-breath diffusing capacity." Respiration; International Review of Thoracic Diseases 84, no. 5 (January 2012): 377-384.

PMID
22213782
Full Text

MacIntyre, NR. "The future of pulmonary function testing." Respir Care 57, no. 1 (January 2012): 154-161.

PMID
22222134
Full Text

MacIntyre, NR. "Mechanical ventilation in the context of a "bag-in-box" respiratory system." Critical Care Medicine 40, no. 6 (2012): 1988-1989.

PMID
22610217
Full Text

Dunne, PJ, MacIntyre, NR, Schmidt, UH, Haas, CF, Rye, KJ-B, Kauffman, GW, and Hess, DR. "Respiratory care year in review 2011: Long-term oxygen therapy, pulmonary rehabilitation, airway management, acute lung injury, education, and management." Respiratory Care 57, no. 4 (2012): 590-606.

PMID
22472499
Full Text

Lau, R, Shih, TK, Li, F, and Yen, NY. "Foreword." Mm'11 Proceedings of the 2011 Acm Multimedia Conference and Co Located Workshops Acm International Workshop on Multimedia Technologies for Distance Learning, Mtdl'11 (December 1, 2011).

Scholars@Duke

Siedlinski, M, Cho, MH, Bakke, P, Gulsvik, A, Lomas, DA, Anderson, W, Kong, X, Rennard, SI, Beaty, TH, Hokanson, JE, Crapo, JD, Silverman, EK, COPDGene Investigators, , and ECLIPSE Investigators, . "Genome-wide association study of smoking behaviours in patients with COPD." Thorax 66, no. 10 (October 2011): 894-902.

PMID
21685187
Full Text

National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, , Matthay, MA, Brower, RG, Carson, S, Douglas, IS, Eisner, M, Hite, D, Holets, S, Kallet, RH, Liu, KD, MacIntyre, N, Moss, M, Schoenfeld, D, Steingrub, J, and Thompson, BT. "Randomized, placebo-controlled clinical trial of an aerosolized β₂-agonist for treatment of acute lung injury." American Journal of Respiratory and Critical Care Medicine 184, no. 5 (September 2011): 561-568.

PMID
21562125
Full Text

Pages