Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Distinguished Research Professor
Professor in Immunology
Research Professor of Global Health
Professor in Pathology
Chief, Division of Cell Therapy in the Department of Medicine
Member of the Duke Cancer Institute
Affiliate of the Duke Regeneration Center
Campus mail 2400 Pratt St Suite 5000, DUMC Box 3961, Durham, NC 27710
Phone (919) 668-1000
Email address nelson.chao@duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Himburg, Heather A., Xiao Yan, Phuong L. Doan, Mamle Quarmyne, Eva Micewicz, William McBride, Nelson J. Chao, Dennis J. Slamon, and John P. Chute. “Pleiotrophin mediates hematopoietic regeneration via activation of RAS.” J Clin Invest 124, no. 11 (November 2014): 4753–58. https://doi.org/10.1172/JCI76838.

PMID
25250571
Full Text

Wang, Chu, Matthew D. Belley, Nelson J. Chao, Mark W. Dewhirst, and Terry Yoshizumi. “Verification of a novel method for tube voltage constancy measurement of orthovoltage x-ray irradiators.” Med Phys 41, no. 8 (August 2014): 084101. https://doi.org/10.1118/1.4889778.

PMID
25086562
Full Text

McClune, Brian L., Kwang Woo Ahn, Hai-Lin Wang, Joseph H. Antin, Andrew S. Artz, Jean-Yves Cahn, Abhinav Deol, et al. “Allotransplantation for patients age ≥40 years with non-Hodgkin lymphoma: encouraging progression-free survival.” Biol Blood Marrow Transplant 20, no. 7 (July 2014): 960–68. https://doi.org/10.1016/j.bbmt.2014.03.013.

PMID
24641829
Full Text

Horwitz, Mitchell E., Nelson J. Chao, David A. Rizzieri, Gwynn D. Long, Keith M. Sullivan, Cristina Gasparetto, John P. Chute, et al. “Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment.” J Clin Invest 124, no. 7 (July 2014): 3121–28. https://doi.org/10.1172/JCI74556.

PMID
24911148
Full Text

Lento, William, Takahiro Ito, Chen Zhao, Jeffrey R. Harris, Wei Huang, Chen Jiang, Kouros Owzar, et al. “Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration.” Genes Dev 28, no. 9 (May 1, 2014): 995–1004. https://doi.org/10.1101/gad.231944.113.

PMID
24788518
Full Text

Lee, Chang-Lung, William E. Lento, Katherine D. Castle, Nelson J. Chao, and David G. Kirsch. “Inhibiting glycogen synthase kinase-3 mitigates the hematopoietic acute radiation syndrome in mice.” Radiat Res 181, no. 5 (May 2014): 445–51. https://doi.org/10.1667/RR13692.1.

PMID
24720754
Full Text

Allen, Jessica L., Prasanthi V. Tata, Matthew S. Fore, Jenna Wooten, Sharmistha Rudra, Allison M. Deal, Andrew Sharf, et al. “Increased BCR responsiveness in B cells from patients with chronic GVHD.” Blood 123, no. 13 (March 27, 2014): 2108–15. https://doi.org/10.1182/blood-2013-10-533562.

PMID
24532806
Full Text

Belley, Matthew D., Chu Wang, Giao Nguyen, Rathnayaka Gunasingha, Nelson J. Chao, Benny J. Chen, Mark W. Dewhirst, and Terry T. Yoshizumi. “Toward an organ based dose prescription method for the improved accuracy of murine dose in orthovoltage x-ray irradiators.” Med Phys 41, no. 3 (March 2014): 034101. https://doi.org/10.1118/1.4864237.

PMID
24593746
Full Text

Rein, Lindsay A. M., and Nelson J. Chao. “WT1 vaccination in acute myeloid leukemia: new methods of implementing adoptive immunotherapy.” Expert Opin Investig Drugs 23, no. 3 (March 2014): 417–26. https://doi.org/10.1517/13543784.2014.889114.

PMID
24521058
Full Text

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