Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Research Professor
Professor in Immunology
Professor in Pathology
Member of the Duke Cancer Institute
Chief, Division of Cell Therapy in the Department of Medicine
Affiliate of the Regeneration Next Initiative
Campus mail 2400 Pratt St Suite 5000, DUMC Box 3961, Durham, NC 27710
Phone (919) 668-1000
Email address nelson.chao@duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Alvarnas, JC, Negrin, RS, Horning, SJ, Hu, WW, Long, GD, Schriber, JR, Stockerl-Goldstein, K, Tierney, K, Wong, R, Blume, KG, and Chao, NJ. "High-Dose Therapy with Hematopoietic Cell Transplantation for Patients with Central Nervous System Involvement by Non-Hodgkin's Lymphoma." Biology of Blood and Marrow Transplantation 6, no. 3 A (January 1, 2000): 352-358.

Full Text

Bhalla, KS, Wilczynski, SW, Abushamaa, AM, Petros, WP, McDonald, CS, Loftis, JS, Chao, NJ, Vredenburgh, JJ, and Folz, RJ. "Pulmonary toxicity of induction chemotherapy prior to standard or high-dose chemotherapy with autologous hematopoietic support." American Journal of Respiratory and Critical Care Medicine 161, no. 1 (January 2000): 17-25.

PMID
10619792
Full Text

Chao, NJ, Snyder, DS, Jain, M, Wong, RM, Niland, JC, Negrin, RS, Long, GD, Hu, WW, Stockerl-Goldstein, KE, Johnston, LJ, Amylon, MD, Tierney, DK, O'Donnell, MR, Nademanee, AP, Parker, P, Stein, A, Molina, A, Fung, H, Kashyap, A, Kohler, S, Spielberger, R, Krishnan, A, Rodriguez, R, Forman, SJ, and Bluzme, KG. "Equivalence of 2 effective graft-versus-host disease prophylaxis regimens: results of a prospective double-blind randomized trial." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 6, no. 3 (January 2000): 254-261.

PMID
10871150
Full Text

Nieto, Y, Cagnoni, PJ, Shpall, EJ, Xu, X, Murphy, J, Vredenburgh, J, Chao, NJ, Bearman, SI, and Jones, RB. "A predictive model for relapse in high-risk primary breast cancer patients treated with high-dose chemotherapy and autologous stem-cell transplant." Clin Cancer Res 5, no. 11 (November 1999): 3425-3431.

PMID
10589754
Scholars@Duke

Hu, WW, Long, GD, Stockerl-Goldstein, KE, Johnston, LJ, Chao, NJ, Negrin, RS, and Blume, KG. "A feasibility study of multiple cycle therapy with melphalan, thiotepa, and paclitaxel followed by mitoxantrone, thiotepa, and paclitaxel with autologous hematopoietic cell support for metastatic breast cancer." Clin Cancer Res 5, no. 11 (November 1999): 3411-3418.

PMID
10589752
Scholars@Duke

Rizzieri, DA, Vredenburgh, JJ, Jones, R, Ross, M, Shpall, EJ, Hussein, A, Broadwater, G, Berry, D, Petros, WP, Gilbert, C, Affronti, ML, Coniglio, D, Rubin, P, Elkordy, M, Long, GD, Chao, NJ, and Peters, WP. "Prognostic and predictive factors for patients with metastatic breast cancer undergoing aggressive induction therapy followed by high-dose chemotherapy with autologous stem-cell support." J Clin Oncol 17, no. 10 (October 1999): 3064-3074.

PMID
10506601
Full Text

Ross, M, Schmidt, GM, Niland, JC, Amylon, MD, Dagis, AC, Long, GD, Nademanee, AP, Negrin, RS, O'Donnell, MR, Parker, PM, Smith, EP, Snyder, DS, Stein, AS, Wong, RM, Forman, SJ, Blume, KG, and Chao, NJ. "Cyclosporine, methotrexate, and prednisone compared with cyclosporine and prednisone for prevention of acute graft-vs.-host disease: effect on chronic graft-vs.-host disease and long-term survival." Biol Blood Marrow Transplant 5, no. 5 (1999): 285-291.

PMID
10534058
Scholars@Duke

Ferrara, JL, Levy, R, and Chao, NJ. "Pathophysiologic mechanisms of acute graft-vs.-host disease." Biol Blood Marrow Transplant 5, no. 6 (1999): 347-356. (Review)

PMID
10595812
Scholars@Duke

Laughlin, MJ, McGaughey, DS, Crews, JR, Chao, NJ, Rizzieri, D, Ross, M, Gockerman, J, Cirrincione, C, Berry, D, Mills, L, Defusco, P, LeGrand, S, Peters, WP, and Vredenburgh, JJ. "Secondary myelodysplasia and acute leukemia in breast cancer patients after autologous bone marrow transplant." J Clin Oncol 16, no. 3 (March 1998): 1008-1012.

PMID
9508184
Full Text

Long, GD, Amylon, MD, Stockerl-Goldstein, KE, Negrin, RS, Chao, NJ, Hu, WW, Nademanee, AP, Snyder, DS, Hoppe, RT, Vora, N, Wong, R, Niland, J, Reichardt, VL, Forman, SJ, and Blume, KG. "Fractionated total-body irradiation, etoposide, and cyclophosphamide followed by allogeneic bone marrow transplantation for patients with high-risk or advanced-stage hematological malignancies." Biol Blood Marrow Transplant 3, no. 6 (December 1997): 324-330.

PMID
9502300
Scholars@Duke

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