Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Research Professor
Professor in Immunology
Research Professor of Global Health
Professor in Pathology
Member of the Duke Cancer Institute
Chief, Division of Cell Therapy in the Department of Medicine
Affiliate of the Regeneration Next Initiative
Campus mail 2400 Pratt St Suite 5000, DUMC Box 3961, Durham, NC 27710
Phone (919) 668-1000
Email address nelson.chao@duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Negrin, R. S., C. R. Kusnierz-Glaz, B. J. Still, J. R. Schriber, N. J. Chao, G. D. Long, C. Hoyle, W. W. Hu, S. J. Horning, and B. W. Brown. “Transplantation of enriched and purged peripheral blood progenitor cells from a single apheresis product in patients with non-Hodgkin's lymphoma..” Blood 85, no. 11 (June 1, 1995): 3334–41.

PMID
7538824
Scholars@Duke

Chao, N. J., H. Kastrissios, G. D. Long, R. S. Negrin, S. J. Horning, R. M. Wong, T. F. Blaschke, and K. G. Blume. “A new preparatory regimen for autologous bone marrow transplantation for patients with lymphoma..” Cancer 75, no. 6 (March 15, 1995): 1354–59. https://doi.org/10.1002/1097-0142(19950315)75:6<1354::aid-cncr2820750618>3.0.co;2-m.

PMID
7882286
Full Text

Chao, N. J., P. G. Schlegel, A. P. Nademanee, K. G. Blume, and S. J. Forman. “Drug prophylaxis for acute graft-versus-host disease.” Bone Marrow Transplantation 15, no. SUPPL. 1 (January 1, 1995).

Scholars@Duke

Fernandez, L. P., P. G. Schlegel, J. Baker, Y. Chen, and N. J. Chao. “Erratum: Does thalidomide affect IL-2 response and production? (Experimental Hematology, 23, 9 (1995), 978-987).” Experimental Hematology 23, no. 12 (January 1, 1995).

Scholars@Duke

Horning, S. J., R. S. Negrin, J. C. Chao, G. D. Long, R. T. Hoppe, and K. G. Blume. “Fractionated total-body irradiation, etoposide, and cyclophosphamide plus autografting in Hodgkin's disease and non-Hodgkin's lymphoma..” J Clin Oncol 12, no. 12 (December 1994): 2552–58. https://doi.org/10.1200/JCO.1994.12.12.2552.

PMID
7989928
Full Text

Schlegel, P. G., R. Aharoni, D. E. Smilek, L. P. Fernandez, H. O. McDevitt, N. Tran, M. Vaysburd, and N. J. Chao. “Prevention of graft-versus-host disease by peptides binding to class II major histocompatibility complex molecules..” Blood 84, no. 8 (October 15, 1994): 2802–10.

PMID
7522644
Scholars@Duke

Snyder, D. S., R. S. Negrin, M. R. O’Donnell, N. J. Chao, M. D. Amylon, G. D. Long, A. P. Nademanee, et al. “Fractionated total-body irradiation and high-dose etoposide as a preparatory regimen for bone marrow transplantation for 94 patients with chronic myelogenous leukemia in chronic phase.” Blood 84, no. 5 (September 1, 1994): 1672–79.

Scholars@Duke

Schriber, J. R., N. J. Chao, G. D. Long, R. S. Negrin, D. K. Tierney, C. Kusnierz-Glaz, K. S. Lucas, and K. G. Blume. “Granulocyte colony-stimulating factor after allogeneic bone marrow transplantation..” Blood 84, no. 5 (September 1, 1994): 1680–84.

PMID
7520782
Scholars@Duke

Snyder, D. S., R. S. Negrin, M. R. O’Donnell, N. J. Chao, M. D. Amylon, G. D. Long, A. P. Nademanee, A. S. Stein, P. M. Parker, and E. P. Smith. “Fractionated total-body irradiation and high-dose etoposide as a preparatory regimen for bone marrow transplantation for 94 patients with chronic myelogenous leukemia in chronic phase..” Blood 84, no. 5 (September 1, 1994): 1672–79.

PMID
8068956
Scholars@Duke

Chao, N. J., J. R. Schriber, G. D. Long, R. S. Negrin, M. Catolico, B. W. Brown, L. L. Miller, and K. G. Blume. “A randomized study of erythropoietin and granulocyte colony-stimulating factor (G-CSF) versus placebo and G-CSF for patients with Hodgkin's and non-Hodgkin's lymphoma undergoing autologous bone marrow transplantation..” Blood 83, no. 10 (May 15, 1994): 2823–28.

PMID
7514046
Scholars@Duke

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