Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Research Professor
Professor in Immunology
ResearchProfessor of Global Health
Professor in Pathology
Member of the Duke Cancer Institute
Chief, Division of Cell Therapy in the Department of Medicine
Affiliate of the Regeneration Next Initiative
Campus mail 1146 N Pavilion, Durham, NC 27710
Phone (919) 668-1011
Email address chao0002@mc.duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Doan, PL, Himburg, HA, Helms, K, Russell, JL, Fixsen, E, Quarmyne, M, Harris, JR, Deoliviera, D, Sullivan, JM, Chao, NJ, Kirsch, DG, and Chute, JP. "Epidermal growth factor regulates hematopoietic regeneration after radiation injury." Nature Medicine 19, no. 3 (March 2013): 295-304.

PMID
23377280
Full Text

Held, LA, Rizzieri, D, Long, GD, Gockerman, JP, Diehl, LF, de Castro, CM, Moore, JO, Horwitz, ME, Chao, NJ, and Gasparetto, C. "A Phase I study of arsenic trioxide (Trisenox), ascorbic acid, and bortezomib (Velcade) combination therapy in patients with relapsed/refractory multiple myeloma." Cancer Investigation 31, no. 3 (March 2013): 172-176.

PMID
23406188
Full Text

Doan, PL, Russell, JL, Himburg, HA, Helms, K, Harris, JR, Lucas, J, Holshausen, KC, Meadows, SK, Daher, P, Jeffords, LB, Chao, NJ, Kirsch, DG, and Chute, JP. "Tie2(+) bone marrow endothelial cells regulate hematopoietic stem cell regeneration following radiation injury." Stem Cells (Dayton, Ohio) 31, no. 2 (February 2013): 327-337.

PMID
23132593
Full Text

Chen, BJ, Jiao, Y, Zhang, P, Sun, AY, Pitt, GS, Deoliveira, D, Drago, N, Ye, T, Liu, C, and Chao, NJ. "Long-term in vivo imaging of multiple organs at the single cell level." Plos One 8, no. 1 (January 2, 2013): e52087-null.

PMID
23300962
Full Text

Sung, AD, and Chao, NJ. "Acute graft-versus-host disease: Are we close to bringing the bench to the bedside?." Bailliere's Best Practice and Research in Clinical Haematology (2013).

Full Text

Zhou, D, Deoliveira, D, Kang, Y, Choi, SS, Li, Z, Chao, NJ, and Chen, BJ. "Insulin-like growth factor 1 mitigates hematopoietic toxicity after lethal total body irradiation." International Journal of Radiation Oncology Biology Physics 85, no. 4 (2013): 1141-1148.

Full Text

Scaradavou, A, Brunstein, CG, Eapen, M, Le-Rademacher, J, Barker, JN, Chao, N, Cutler, C, Delaney, C, Kan, F, Isola, L, Karanes, C, Laughlin, MJ, Wagner, JE, and Shpall, EJ. "Double unit grafts successfully extend the application of umbilical cord blood transplantation in adults with acute leukemia." Blood 121, no. 5 (2013): 752-758.

PMID
23223509
Full Text

Sung, AD, and Chao, NJ. "Concise review: acute graft-versus-host disease: immunobiology, prevention, and treatment." Stem Cells Translational Medicine 2, no. 1 (January 2013): 25-32. (Review)

PMID
23283494
Full Text

Forman, SJ, Negrin, R, and Chao, N. "Karl Georg Blume, MD." Biology of Blood and Marrow Transplantation 19, no. 6 (2013): 845-846.

Full Text

Chao, N. "Blazing a new TRAIL in hematopoietic cell transplantation." Journal of Clinical Investigation 123, no. 6 (2013): 2362-2363.

PMID
23676458
Full Text

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