Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Distinguished Research Professor
Professor in Immunology
Research Professor of Global Health
Professor in Pathology
Chief, Division of Cell Therapy in the Department of Medicine
Member of the Duke Cancer Institute
Affiliate of the Duke Regeneration Center
Campus mail 2400 Pratt St Suite 5000, DUMC Box 3961, Durham, NC 27710
Phone (919) 668-1000
Email address nelson.chao@duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Liu, Yang, Wei Huang, Chuanfeng Xiong, Yuxian Huang, Benny J. Chen, Luigi Racioppi, Nelson Chao, and Tuan Vo-Dinh. “Biodistribution and sensitive tracking of immune cells with plasmonic gold nanostars.” Int J Nanomedicine 14 (2019): 3403–11. https://doi.org/10.2147/IJN.S192189.

PMID
31190799
Full Text

Jauhari, S., and N. Chao. “Novel Cellular Therapeutic Approaches for the Prevention and Management of Graft-Versus-Host Disease.” Current Stem Cell Reports 4, no. 4 (December 1, 2018): 318–26. https://doi.org/10.1007/s40778-018-0146-4.

Full Text

Poe, Jonathan C., Wei Jia, Julie A. Di Paolo, Nancy J. Reyes, Ji Yun Kim, Hsuan Su, John S. Sundy, et al. “SYK inhibitor entospletinib prevents ocular and skin GVHD in mice.” Jci Insight 3, no. 19 (October 4, 2018). https://doi.org/10.1172/jci.insight.122430.

PMID
30282825
Full Text

Schroeder, Kristin, Anthony Saxton, Jessica McDade, Christina Chao, Nestory Masalu, Colin Chao, Daniel S. Wechsler, Beda Likonda, and Nelson Chao. “Pediatric Cancer in Northern Tanzania: Evaluation of Diagnosis, Treatment, and Outcomes.” J Glob Oncol 4 (September 2018): 1–10. https://doi.org/10.1200/JGO.2016.009027.

PMID
30241177
Full Text

Rein, Lindsay A. M., Haeyoon Yang, and Nelson J. Chao. “Applications of Gene Editing Technologies to Cellular Therapies.” Biol Blood Marrow Transplant 24, no. 8 (August 2018): 1537–45. https://doi.org/10.1016/j.bbmt.2018.03.021.

PMID
29601858
Full Text

Sivaraj, Dharshan, Michael M. Green, Yubin Kang, Gwynn D. Long, David A. Rizzieri, Zhiguo Li, Anderson H. Garrett, Jackie L. McIntyre, Nelson J. Chao, and Cristina Gasparetto. “Bendamustine, pomalidomide, and dexamethasone for relapsed and/or refractory multiple myeloma.” Blood Cancer J 8, no. 8 (July 31, 2018): 71. https://doi.org/10.1038/s41408-018-0104-5.

PMID
30065277
Full Text

Turcotte, Lucie M., Tao Wang, Michael T. Hemmer, Stephen R. Spellman, Mukta Arora, Daniel Couriel, Amin Alousi, et al. “Donor body mass index does not predict graft versus host disease following hematopoietic cell transplantation.” Bone Marrow Transplant 53, no. 7 (July 2018): 932–37. https://doi.org/10.1038/s41409-018-0100-1.

PMID
29382954
Full Text

Ai, Hui-Sheng, Mei Guo, and Nelson J. Chao. “Study Limitations in HLA-Mismatched Microtransplant in Older Patients Newly Diagnosed With Acute Myeloid Leukemia-Reply.” Jama Oncol 4, no. 6 (June 1, 2018): 891. https://doi.org/10.1001/jamaoncol.2018.0367.

PMID
29710175
Full Text

Messina, Julia A., Rohita Sinha, Kimberly Starr, Mehreen Arshad, Barbara D. Alexander, Nelson J. Chao, and Anthony D. Sung. “Clinical and Genomic Characterization of Recurrent Enterococcal Bloodstream Infection in Patients With Acute Leukemia.” Open Forum Infect Dis 5, no. 6 (June 2018): ofy107. https://doi.org/10.1093/ofid/ofy107.

PMID
29977964
Full Text

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