Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Distinguished Research Professor
Professor in Immunology
Research Professor of Global Health
Professor in Pathology
Member of the Duke Cancer Institute
Chief, Division of Cell Therapy in the Department of Medicine
Affiliate of the Regeneration Next Initiative
Campus mail 2400 Pratt St Suite 5000, DUMC Box 3961, Durham, NC 27710
Phone (919) 668-1000
Email address nelson.chao@duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Allewelt, Heather, Paul L. Martin, Paul Szabolcs, Nelson Chao, Rebecca Buckley, and Suhag Parikh. “Hematopoietic Stem Cell Transplantation for CD40 Ligand Deficiency: Single Institution Experience.” Pediatr Blood Cancer 62, no. 12 (December 2015): 2216–22. https://doi.org/10.1002/pbc.25711.

PMID
26291959
Full Text

Zhang, Baojun, Jianxuan Wu, Yiqun Jiao, Cheryl Bock, Meifang Dai, Benny Chen, Nelson Chao, Weiguo Zhang, and Yuan Zhuang. “Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells.” J Immunol 195, no. 9 (November 1, 2015): 4282–91. https://doi.org/10.4049/jimmunol.1501220.

PMID
26408667
Full Text

Olson, Adam C., C Norman Coleman, Stephen M. Hahn, Theodore L. DeWeese, Lawrence N. Shulman, Bruce A. Chabner, Nelson Chao, Yehoda M. Martei, Arno J. Mundt, and Surbhi Grover. “A Roadmap for a New Academic Pathway for Global Radiation Oncology.” Int J Radiat Oncol Biol Phys 93, no. 3 (November 1, 2015): 493–96. https://doi.org/10.1016/j.ijrobp.2015.06.023.

PMID
26460990
Full Text

Inamoto, Yoshihiro, Mary E. D. Flowers, Tao Wang, Alvaro Urbano-Ispizua, Michael T. Hemmer, Corey S. Cutler, Daniel R. Couriel, et al. “Tacrolimus versus Cyclosporine after Hematopoietic Cell Transplantation for Acquired Aplastic Anemia.” Biol Blood Marrow Transplant 21, no. 10 (October 2015): 1776–82. https://doi.org/10.1016/j.bbmt.2015.05.023.

PMID
26033280
Full Text

Brenner, David J., Nelson J. Chao, Joel S. Greenberger, Chandan Guha, William H. McBride, Harold M. Swartz, and Jacqueline P. Williams. “Are We Ready for a Radiological Terrorist Attack Yet? Report From the Centers for Medical Countermeasures Against Radiation Network.” Int J Radiat Oncol Biol Phys 92, no. 3 (July 1, 2015): 504–5. https://doi.org/10.1016/j.ijrobp.2015.02.042.

PMID
26068482
Full Text

Flynn, Ryan, Jessica L. Allen, Leo Luznik, Kelli P. MacDonald, Katelyn Paz, Kylie A. Alexander, Ante Vulic, et al. “Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease.” Blood 125, no. 26 (June 25, 2015): 4085–94. https://doi.org/10.1182/blood-2014-08-595470.

PMID
25852057
Full Text

Tuchman, Sascha A., Wendi A. Bacon, Li-Wen Huang, Gwynn Long, David Rizzieri, Mitchell Horwitz, John P. Chute, et al. “Cyclophosphamide-based hematopoietic stem cell mobilization before autologous stem cell transplantation in newly diagnosed multiple myeloma.” J Clin Apher 30, no. 3 (June 2015): 176–82. https://doi.org/10.1002/jca.21360.

PMID
25293363
Full Text

DeBo, Ryne J., Thomas C. Register, David L. Caudell, Gregory D. Sempowski, Gregory Dugan, Shauna Gray, Kouros Owzar, et al. “Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques.” Int J Radiat Biol 91, no. 6 (June 2015): 510–18. https://doi.org/10.3109/09553002.2015.1028597.

PMID
25786585
Full Text

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