Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Research Professor
Professor in Immunology
ResearchProfessor of Global Health
Professor in Pathology
Member of the Duke Cancer Institute
Chief, Division of Cell Therapy in the Department of Medicine
Affiliate of the Regeneration Next Initiative
Campus mail 1146 N Pavilion, Durham, NC 27710
Phone (919) 668-1011
Email address chao0002@mc.duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Chen, D-F, Prasad, VK, Broadwater, G, Reinsmoen, NL, DeOliveira, A, Clark, A, Sullivan, KM, Chute, JP, Horwitz, ME, Gasparetto, C, Long, GD, Yang, Y, Chao, NJ, and Rizzieri, DA. "Differential impact of inhibitory and activating Killer Ig-Like Receptors (KIR) on high-risk patients with myeloid and lymphoid malignancies undergoing reduced intensity transplantation from haploidentical related donors." Bone Marrow Transplant 47, no. 6 (June 2012): 817-823.

PMID
22139069
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Kanda, J, Horwitz, ME, Long, GD, Gasparetto, C, Sullivan, KM, Chute, JP, Morris, A, Hennig, T, Li, Z, Chao, NJ, and Rizzieri, DA. "Outcomes of a 1-day nonmyeloablative salvage regimen for patients with primary graft failure after allogeneic hematopoietic cell transplantation." Bone Marrow Transplant 47, no. 5 (May 2012): 700-705.

PMID
21804612
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Jagasia, M, Arora, M, Flowers, MED, Chao, NJ, McCarthy, PL, Cutler, CS, Urbano-Ispizua, A, Pavletic, SZ, Haagenson, MD, Zhang, M-J, Antin, JH, Bolwell, BJ, Bredeson, C, Cahn, J-Y, Cairo, M, Gale, RP, Gupta, V, Lee, SJ, Litzow, M, Weisdorf, DJ, Horowitz, MM, and Hahn, T. "Risk factors for acute GVHD and survival after hematopoietic cell transplantation." Blood 119, no. 1 (January 2012): 296-307.

PMID
22010102
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Chao, N. "You Cannot Improve What You Do Not Measure." Biology of Blood and Marrow Transplantation 18, no. 10 (2012): 1467-1468.

PMID
22771840
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Chao, N. "Control of GVHD: It's in our DNA!." Blood 119, no. 5 (2012): 1102-1103.

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Tuchman, SA, Chao, NJ, and Gasparetto, CG. "Lenalidomide before and after Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma." Adv Hematol 2012 (2012): 712613-.

PMID
22690220
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Confer, DL, Weisdorf, D, Weinstock, D, Case, C, and Chao, N. "Radiation Disasters: Role of the BMT Team." Biology of Blood and Marrow Transplantation 18, no. 1 SUPPL. (2012): S189-S192.

PMID
22226106
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Lee, HR, Park, JS, Shin, S, Roh, EY, Yoon, JH, Han, KS, Kim, BJ, Storms, RW, and Chao, NJ. "Increased numbers of total nucleated and CD34+ cells in blood group O cord blood: An analysis of neonatal innate factors in the Korean population." Transfusion 52, no. 1 (2012): 76-81.

PMID
21790633
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Coleman, CN, Adams, S, Adrianopoli, C, Ansari, A, Bader, JL, Buddemeier, B, Caro, JJ, Casagrande, R, Case, C, Caspary, K, Chang, AS, Chang, HF, Chao, N, Cliffer, KD, Confer, D, Deitchman, S, Derenzo, EG, Dobbs, A, Dodgen, D, Donnelly, EH, Gorman, S, Grace, MB, Hatchett, R, Hick, JL, Hrdina, C, Jones, R, Kane, E, Knebel, A, Koerner, JF, Laffan, AM, Larson, L, Livinski, A, MacKinney, J, Maidment, BW, Manning, R, Marinissen, MJ, Martin, C, Michael, G, Murrain-Hill, P, Nemhauser, JB, and Norwood, AE et al. "Medical planning and response for a nuclear detonation: A practical guide." Biosecurity and Bioterrorism 10, no. 4 (2012): 346-371.

PMID
23244500
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Kang, Y, and Chao, NJ. "Strategies to enhance hematopoietic stem cell engraftment following transplantation." In Novel Developments in Stem Cell Mobilization: Focus on CXCR4, 439-456. January 1, 2012.

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