Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Research Professor
Professor in Immunology
ResearchProfessor of Global Health
Professor in Pathology
Member of the Duke Cancer Institute
Chief, Division of Cell Therapy in the Department of Medicine
Affiliate of the Regeneration Next Initiative
Campus mail 1146 N Pavilion, Durham, NC 27710
Phone (919) 668-1011
Email address chao0002@mc.duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Deoliveira, D, Jiao, Y, Ross, JR, Corbin, K, Xiao, Q, Toncheva, G, Anderson-Evans, C, Yoshizumi, TT, Chen, BJ, and Chao, NJ. "An ear punch model for studying the effect of radiation on wound healing." Int J Radiat Biol 87, no. 8 (August 2011): 869-877.

PMID
21480768
Full Text

Kanda, J, Rizzieri, DA, Gasparetto, C, Long, GD, Chute, JP, Sullivan, KM, Morris, A, Smith, CA, Hogge, DE, Nitta, J, Song, K, Niedzwiecki, D, Chao, NJ, and Horwitz, ME. "Adult dual umbilical cord blood transplantation using myeloablative total body irradiation (1350 cGy) and fludarabine conditioning." Biol Blood Marrow Transplant 17, no. 6 (June 2011): 867-874.

PMID
20868761
Full Text

Zhang, P, Chen, BJ, and Chao, NJ. "Prevention of GVHD without losing GVL effect: windows of opportunity." Immunol Res 49, no. 1-3 (April 2011): 49-55. (Review)

PMID
21136200
Full Text

Craciunescu, OI, Steffey, BA, Kelsey, CR, Larrier, NA, Paarz-Largay, CJ, Prosnitz, RG, Chao, N, Chute, J, Gasparetto, C, Horwitz, M, Long, G, Rizzieri, D, and Sullivan, KM. "Renal shielding and dosimetry for patients with severe systemic sclerosis receiving immunoablation with total body irradiation in the scleroderma: cyclophosphamide or transplantation trial." Int J Radiat Oncol Biol Phys 79, no. 4 (March 15, 2011): 1248-1255.

PMID
20800376
Full Text

Rizzieri, DA, Crout, C, Storms, R, Golob, J, Long, GD, Gasparetto, C, Sullivan, KM, Horwitz, M, Chute, J, Lagoo, AS, Morris, A, Beaven, A, Yang, Y, Peterson, B, Li, Z, and Chao, NJ. "Feasibility of low-dose interleukin-2 therapy following T-cell-depleted nonmyeloablative allogeneic hematopoietic stem cell transplantation from HLA-matched or -mismatched family member donors." Cancer Invest 29, no. 1 (January 2011): 56-61.

PMID
21166499
Full Text

Palmer, J, Goggins, T, Broadwater, G, Chao, N, Horwitz, M, Beaven, A, Sullivan, K, Coleman, RE, and Rizzieri, D. "Early post transplant (F-18) 2-fluoro-2-deoxyglucose positron emission tomography does not predict outcome for patients undergoing auto-SCT in non-Hodgkin and Hodgkin lymphoma." Bone Marrow Transplantation 46, no. 6 (2011): 847-851.

PMID
20856212
Full Text

Dainiak, N, Gent, RN, Carr, Z, Schneider, R, Bader, J, Buglova, E, Chao, N, Coleman, CN, Ganser, A, Gorin, C, Hauer-Jensen, M, Huff, LA, Lillis-Hearne, P, Maekawa, K, Nemhauser, J, Powles, R, Schunemann, H, Shapiro, A, Stenke, L, Valverde, N, Weinstock, D, White, D, Albanese, J, and Meineke, V. "Literature review and global consensus on management of acute radiation syndrome affecting nonhematopoietic organ systems." Disaster Medicine and Public Health Preparedness 5, no. 3 (2011): 183-201.

PMID
21986999
Full Text

Dainiak, N, Gent, RN, Carr, Z, Schneider, R, Bader, J, Buglova, E, Chao, N, Coleman, CN, Ganser, A, Gorin, C, Hauer-Jensen, M, Huff, LA, Lillis-Hearne, P, Maekawa, K, Nemhauser, J, Powles, R, Schunemann, H, Shapiro, A, Stenke, L, Valverde, N, Weinstock, D, White, D, Albanese, J, and Meineke, V. "First global consensus for evidence-based management of the hematopoietic syndrome resulting from exposure to ionizing radiation." Disaster Medicine and Public Health Preparedness 5, no. 3 (2011): 202-212.

PMID
21987000
Full Text

Ross, JR, Case, C, Confer, D, Weisdorf, DJ, Weinstock, D, Krawisz, R, Chute, J, Wilhauk, J, Navarro, W, Hartzman, R, Coleman, CN, Hatchett, R, and Chao, N. "Radiation injury treatment network (RITN): Healthcare professionals preparing for a mass casualty radiological or nuclear incident." International Journal of Radiation Biology 87, no. 8 (2011): 748-753.

PMID
21801106
Full Text

Weisdorf, D, Weinstock, D, Case, C, Chao, N, and Confer, DL. "Planning and Response to Radiation Exposures." Biology of Blood and Marrow Transplantation 17, no. 8 (2011): 1262-1263.

PMID
21723406
Full Text

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