Nishad Jayasundara, PhD

Assistant Professor of Environmental Toxicology and Health
Assistant Research Professor of Global Health
Assistant Professor in Medicine
Email address nj58@duke.edu

Dr. Jayasundara studies adverse ecological and human health outcomes of anthropogenic environmental change. Specifically, Dr. Jayasundara focuses on various teleost fish species (e.g., zebrafish Danio rerio  and Atlantic killifish Fundulus heteroclitus) and conduct field and laboratory studies that integrate functional genomics analyses, in vitro and in vivo physiological and biochemical assays, and mathematical modeling approaches. Ongoing projects aim to:

1. Determine interactive effects of metals and pesticides on kidney mitochondrial function in the context of chronic kidney disease epidemic in agricultural communities based on environmental epidemiology and mechanistic toxicology studies.

2. Examine mitochondrial responses to acute and chronic exposure to heat stress during organismal development and linking to later-life metabolic consequences 

3. Elucidate the role of genetic, epigenetic, and gut microbiome shifts in evolved resistance to chemical pollutants.  

4. Assess rural water quality through citizen science and community engagement in Maine and Sri Lanka

Education and Training

  • Ph.D., Stanford University, 2012

Publications

Gearhart-Serna, Larisa M., John B. Davis, Mohit Kumar Jolly, Nishad Jayasundara, Scott J. Sauer, Richard T. Di Giulio, and Gayathri R. Devi. “A polycyclic aromatic hydrocarbon-enriched environmental chemical mixture enhances AhR, antiapoptotic signaling and a proliferative phenotype in breast cancer cells.” Carcinogenesis 41, no. 12 (December 31, 2020): 1648–59. https://doi.org/10.1093/carcin/bgaa047.

PMID
32747956
Full Text

Gunasekara, T. D. K. S. C., P Mangala C. S. De Silva, Chula Herath, Sisira Siribaddana, Nipuna Siribaddana, Channa Jayasumana, Sudheera Jayasinghe, Maria Cardenas-Gonzalez, and Nishad Jayasundara. “The Utility of Novel Renal Biomarkers in Assessment of Chronic Kidney Disease of Unknown Etiology (CKDu): A Review.” International Journal of Environmental Research and Public Health 17, no. 24 (December 18, 2020): E9522. https://doi.org/10.3390/ijerph17249522.

PMID
33353238
Full Text

Babich, Remy, Jake C. Ulrich, EM Dilini V. Ekanayake, Andrey Massarsky, P Mangala C. S. De Silva, Pathmalal M. Manage, Brian P. Jackson, et al. “Kidney developmental effects of metal-herbicide mixtures: Implications for chronic kidney disease of unknown etiology.” Environment International 144 (November 2020): 106019. https://doi.org/10.1016/j.envint.2020.106019.

PMID
32818823
Full Text

Babich, Remy, Heather Hamlin, LeeAnne Thayer, Madeline Dorr, Zheng Wei, Andrew Neilson, and Nishad Jayasundara. “Mitochondrial response and resilience to anthropogenic chemicals during embryonic development.” Comparative Biochemistry and Physiology. Toxicology & Pharmacology : Cbp 233 (July 2020): 108759. https://doi.org/10.1016/j.cbpc.2020.108759.

PMID
32259593
Full Text

Volkoff, Savannah J., Joshua S. Osterberg, Nishad Jayasundara, Ellen Cooper, Heileen Hsu-Kim, Laura Rogers, Gretchen E. Gehrke, Saro Jayaraman, and Richard T. Di Giulio. “Embryonic Fundulus heteroclitus responses to sediment extracts from differentially contaminated sites in the Elizabeth River, VA.” Ecotoxicology (London, England) 28, no. 9 (November 2019): 1126–35. https://doi.org/10.1007/s10646-019-02116-z.

PMID
31620948
Full Text

Lowndes, Julia S Stewart, Halley E. Froehlich, Allison Horst, Nishad Jayasundara, Malin L. Pinsky, Adrian C. Stier, Nina O. Therkildsen, and Chelsea L. Wood. “Supercharge your research: a ten-week plan for open data science.” Nature, October 31, 2019. https://doi.org/10.1038/d41586-019-03335-4.

PMID
33122833
Full Text

Jayasundara, N., J. Kozal, A. Massarsky, R. Trevisan, M. Blue, A. J. Bone, C. D. Lindberg, and R. T. Di Giulio. “Later-life persistent bioenergetic effects of exposure to multiple mitochondrial stressors during development in zebrafish Danio rerio.” In Integrative and Comparative Biology, 59:E342–E342. OXFORD UNIV PRESS INC, 2019.

Scholars@Duke

Gearhart-Serna, L. M., J. B. Davis, N. Jayasundara, M. K. Jolly, S. J. Sauer, H. Levine, R. T. Di Giulio, and G. R. Devi. “Exposure to a Naturally Occurring Polycyclic Aromatic Hydrocarbon Mixture Triggers an Aggressive Phenotype in Estrogen Receptor-Positive Breast Cancer Cells.” In International Journal of Toxicology, 38:37–38. SAGE PUBLICATIONS INC, 2019.

Scholars@Duke

Massarsky, Andrey, Nishad Jayasundara, Lilah Glazer, Edward D. Levin, G. L. Prasad, and Richard T. Di Giulio. “Outcomes of developmental exposure to total particulate matter from cigarette smoke in zebrafish (Danio rerio).” Neurotoxicology 68 (September 2018): 101–14. https://doi.org/10.1016/j.neuro.2018.07.003.

PMID
30026038
Full Text

Wanner, N., M. Colwell, N. Jayasundara, R. Di Giulio, and C. Faulk. “DNA Methylation of Ultraconserved Noncoding Elements in Atlantic Killifish (Fundulus heteroclitus) Exposed to Environmental Polycyclic Aromatic Hydrocarbons (PAHs).” In Environmental and Molecular Mutagenesis, 59:94–94, 2018.

Scholars@Duke

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