P. Murali Doraiswamy, MBBS

Professor of Psychiatry and Behavioral Sciences
Director, Neurocognitive Disorders Program
Professor in Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Affiliate of the Duke Initiative for Science & Society
Senior Fellow of the Center for the Study of Aging and Human Development
Affiliate in the Duke Center for Applied Genomics and Precision Medicine
Campus mail 3550 Hosp South, Durham, NC 27710

Murali Doraiswamy MBBS FRCP is Professor of Psychiatry and Professor in Medicine at Duke University School of Medicine where he is a highly cited physician scientist at the Duke Institute for Brain Sciences.  He is also a Senior Fellow at the Duke Center for the Study of Aging and an Affiliate Faculty at the Duke Center for Precision Medicine and Applied Genomics as well as the Duke Microbiome Center.  He directs a clinical trials unit that has been involved in the development of many modern diagnostic tests, apps, algorithms, and therapeutics in wide use today.  Prof Doraiswamy has been an advisor to leading government agencies, businesses and advocacy groups including the NIH, FDA, and WHO as well as numerous life science companies. He has served as the chair of the World Economic Forum’s Global Agenda Council on Brain Research and co-chaired the innovation advisory council for one of the world’s largest social impact funds dedicated to promoting innovative solutions to reverse age related disorders.  He has lectured at leading global forums to advance the forefront of aging and neuroscience research.  Moreover as an investigator on numerous landmark trials and co-author on more than 400 publications, he has received several awards in recognition of his scientific work.  Additionally, he is a leading advocate for increasing funding for brain and behavioral research to help address great looming challenges in society posed by modern developments in the 21st century. His research has been featured in media outlets such as BBC, The New York Times, Scientific American, The Wall Street Journal, National Public Radio, CBS Evening news, The Dr Oz Show, Oprah, and TIME. He has appeared in acclaimed documentaries such as (Dis)Honesty: The Truth about Lies and Mysteries of the Brain. He is the co-author of a popular book The Alzheiemr's Action Plan. Prof. Doraiswamy also serves on the board of several global charities.  

  

Education and Training

  • M.B.B.S., University of Madras (India), 1987

Publications

Nho, Kwangsik, Alexandra Kueider-Paisley, Siamak MahmoudianDehkordi, Matthias Arnold, Shannon L. Risacher, Gregory Louie, Colette Blach, et al. “Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers.” Alzheimers Dement 15, no. 2 (February 2019): 232–44. https://doi.org/10.1016/j.jalz.2018.08.012.

PMID
30337152
Full Text

Privitera, Gregory J., Quentin W. King-Shepard, Kayla N. Cuifolo, and P Murali Doraiswamy. “Differential food intake and food choice by depression and body mass index levels following a mood manipulation in a buffet-style setting.” J Health Psychol 24, no. 2 (February 2019): 199–208. https://doi.org/10.1177/1359105316650508.

PMID
27206838
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Blumenthal, James A., Patrick J. Smith, Stephanie Mabe, Alan Hinderliter, Pao-Hwa Lin, Lawrence Liao, Kathleen A. Welsh-Bohmer, et al. “Lifestyle and neurocognition in older adults with cognitive impairments: A randomized trial.” Neurology 92, no. 3 (January 15, 2019): e212–23. https://doi.org/10.1212/WNL.0000000000006784.

PMID
30568005
Full Text

Smith, Patrick J., Stephanie Mabe, Andrew Sherwood, Michael A. Babyak, P Murali Doraiswamy, Kathleen A. Welsh-Bohmer, William Kraus, James Burke, Alan Hinderliter, and James A. Blumenthal. “Association Between Insulin Resistance, Plasma Leptin, and Neurocognition in Vascular Cognitive Impairment.” J Alzheimers Dis 71, no. 3 (2019): 921–29. https://doi.org/10.3233/JAD-190569.

PMID
31476159
Full Text

Smilnak, Gordon J., John R. Deans, P Murali Doraiswamy, Sandra Stinnett, Heather E. Whitson, and Eleonora M. Lad. “Comorbidity of age-related macular degeneration with Alzheimer's disease: A histopathologic case-control study.” Plos One 14, no. 9 (2019): e0223199. https://doi.org/10.1371/journal.pone.0223199.

PMID
31568508
Full Text

Tolbert, S., Y. Liu, C. Hellegers, J. R. Petrella, M. W. Weiner, T. Z. Wong, and P. Murali Doraiswamy. “Financial Management Skills in Aging, MCI and Dementia: Cross Sectional Relationship to 18F-Florbetapir PET Cortical β-amyloid Deposition.” J Prev Alzheimers Dis 6, no. 4 (2019): 274–82. https://doi.org/10.14283/jpad.2019.26.

PMID
31686100
Full Text

MahmoudianDehkordi, Siamak, Matthias Arnold, Kwangsik Nho, Shahzad Ahmad, Wei Jia, Guoxiang Xie, Gregory Louie, et al. “Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome.” Alzheimers Dement 15, no. 1 (January 2019): 76–92. https://doi.org/10.1016/j.jalz.2018.07.217.

PMID
30337151
Full Text

Petrella, Jeffrey R., Wenrui Hao, Adithi Rao, and P Murali Doraiswamy. “Computational Causal Modeling of the Dynamic Biomarker Cascade in Alzheimer's Disease.” Comput Math Methods Med 2019 (2019): 6216530. https://doi.org/10.1155/2019/6216530.

PMID
30863455
Full Text

Motter, Jeffrey N., Gregory H. Pelton, Kristina D’Antonio, Sara N. Rushia, Monique A. Pimontel, Jeffrey R. Petrella, Ernst Garcon, et al. “Clinical and radiological characteristics of early versus late mild cognitive impairment in patients with comorbid depressive disorder.” Int J Geriatr Psychiatry 33, no. 12 (December 2018): 1604–12. https://doi.org/10.1002/gps.4955.

PMID
30035339
Full Text

Devanand, Davangere P., Gregory H. Pelton, Kristina D’Antonio, Adam Ciarleglio, Jennifer Scodes, Howard Andrews, Julia Lunsford, et al. “Donepezil Treatment in Patients With Depression and Cognitive Impairment on Stable Antidepressant Treatment: A Randomized Controlled Trial.” Am J Geriatr Psychiatry 26, no. 10 (October 2018): 1050–60. https://doi.org/10.1016/j.jagp.2018.05.008.

PMID
30037778
Full Text

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