Patricia Lynne Lugar, MD

Associate Professor of Medicine
Associate Professor in Pediatrics
Campus mail 1821 Hillandale Rd, Suite 25A, Durham, NC 27705
Phone (919) 613-5707
Email address patricia.lugar@duke.edu

I have a strong interest and research background in the study of dysregulated B lymphocytes, B cells, that characterize clinical disease such as autoimmune disease and humoral immune deficiency. My current research projects are aimed at the study of humoral immune deficiency, specifically common variable immune deficiency or CVID and the dysregulation of B cells in the generation of lymphoma and autoimmune disease.
Other ongoing research projects include characterizing the molecular and cellular events that cause a common disease, chronic idiopathic urticaria or CIU and rare disorders idiopathic anaphylaxis and idiopathic angioedema.

Education and Training

  • Fellowship in Allegy and Immunology, Niaid, National Institutes of Health, 2003 - 2006
  • Medical Resident, Medicine, Northwestern University, 1999 - 2002
  • M.D., State University of New York - Buffalo, 1999

Publications

Chang, H. L., M. Melchers, H. Wang, T. A. Torrey, R. Slota, C. F. Qi, Y. K. Ji, et al. “Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein (Journal of Experimental Medicine (January 23, 2006) 203, 1, (63-72)).” Journal of Experimental Medicine 205, no. 6 (June 9, 2008): 1507. https://doi.org/10.1084/jem.20051450051208c.

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Fiorini, Claudia, Vassilios Lougaris, Patricia L. Lugar, Rebecca Slota, Boris van der Zouwen, Mark Melchers, David R. Withers, et al. “TNFSF5/CD154/CD40L engagement on activated B cells from SLE periphery or the tonsil induces proximal signaling events and differentiation to plasma cells.” In Arthritis and Rheumatism, 54:S567–68. WILEY-LISS, 2006.

Scholars@Duke

Lugar, Patricia Lynne, Randy Fischer, Rebecca Slota, Terry Phillips, Peter Lipsky, and Amrie C. Grammer. “Gene expression, phenotypic and proteomic profile of Ig-secreting plasma cells in the periphery of patients with active SLE.” In Journal of Immunology, 176:S136–S136. AMER ASSOC IMMUNOLOGISTS, 2006.

Scholars@Duke

Slota, Rebecca, Randy Fischer, Nancy Longo, Patricia Lynne Lugar, Gabor Illei, Terry Phillips, Peter Lipsky, and Amrie Grammer. “Functional and phenotypic characterization of anergic B cells circulating in the periphery of patients with systemic lupus erythematosus.” In Journal of Immunology, 176:S156–S156. AMER ASSOC IMMUNOLOGISTS, 2006.

Scholars@Duke

Chang, H. L., M. Melchers, H. Wang, T. A. Torrey, R. Slota, C. F. Qi, Y. K. Ji, et al. “Erratum: (Journal of Experimental Medicine (January 23, 2006) 203:1 (63-72)).” Journal of Experimental Medicine 203, no. 2 (February 20, 2006): 475. https://doi.org/10.1084/jem.20051450012506c.

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Lugar, P. L., R. Slota, R. T. Fischer, D. Withers, P. Pisitkun, P. E. Lipsky, and A. C. Grammer. “Functional Regulation of Normal and SLE Plasma Cells by DCC (Deleted in Colon Cancer) and its Ligand Netrin-1.” In Journal of Allergy and Clinical Immunology, 117:S19–S19. Elsevier BV, 2006. https://doi.org/10.1016/j.jaci.2005.12.079.

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Lee, Chang Hoon, Mark Melchers, Hongsheng Wang, Ted A. Torrey, Rebecca Slota, Chen-Feng Qi, Ji Young Kim, et al. “Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein.” J Exp Med 203, no. 1 (January 23, 2006): 63–72. https://doi.org/10.1084/jem.20051450.

PMID
16380510
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