Paul Grimsrud, PhD

Assistant Professor in Medicine
Member of Duke Molecular Physiology Institute
Campus mail 104775, Durham, NC 27701
Phone (919) 684-0631
Email address paul.grimsrud@duke.edu

Paul Grimsrud is an Assistant professor of Medicine—in the Division of Endocrinology, Metabolism, and Nutrition—and Proteomics Section Leader at the Duke Molecular Physiology Institute. He completed a PhD in Biochemistry at the University of Minnesota-Twin Cities and a postdoctoral fellowship at the University of Wisconsin-Madison. His research combines mass spectrometry-based proteomics with complementary biochemical approaches to characterize the regulation of metabolism and signaling by protein post-translational modifications (PTMs). He is particularly interested in mechanisms that link altered mitochondrial function to metabolic diseases, such as heart failure, type 2 diabetes, and cancer. He works with colleagues to apply quantitative PTM measurements to relevant model systems, leverage bioinformatics tools to develop testable hypotheses from large-scale data, and characterize mechanisms of PTM-mediated metabolic control.

Education and Training

  • Ph.D., University of Minnesota, Twin Cities, 2008

Publications

Hershberger, Kathleen A., Dennis M. Abraham, Juan Liu, Jason W. Locasale, Paul A. Grimsrud, and Matthew D. Hirschey. “Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload.” J Biol Chem 293, no. 27 (July 6, 2018): 10630–45. https://doi.org/10.1074/jbc.RA118.002187.

PMID
29769314
Full Text

Peterson, Brett S., Jonathan E. Campbell, Olga Ilkayeva, Paul A. Grimsrud, Matthew D. Hirschey, and Christopher B. Newgard. “Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition.” Cell Rep 24, no. 1 (July 3, 2018): 209-223.e6. https://doi.org/10.1016/j.celrep.2018.05.088.

PMID
29972782
Full Text

White, Phillip J., Robert W. McGarrah, Paul A. Grimsrud, Shih-Chia Tso, Wen-Hsuan Yang, Jonathan M. Haldeman, Thomas Grenier-Larouche, et al. “The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.” Cell Metab 27, no. 6 (June 5, 2018): 1281-1293.e7. https://doi.org/10.1016/j.cmet.2018.04.015.

PMID
29779826
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Martin, Angelical S., Dennis M. Abraham, Kathleen A. Hershberger, Dhaval P. Bhatt, Lan Mao, Huaxia Cui, Juan Liu, et al. “Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model.” Jci Insight 2, no. 14 (July 20, 2017). https://doi.org/10.1172/jci.insight.93885.

PMID
28724806
Full Text

Anderson, Kristin A., Frank K. Huynh, Kelsey Fisher-Wellman, J Darren Stuart, Brett S. Peterson, Jonathan D. Douros, Gregory R. Wagner, et al. “SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.” Cell Metab 25, no. 4 (April 4, 2017): 838-855.e15. https://doi.org/10.1016/j.cmet.2017.03.003.

PMID
28380376
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Wagner, Gregory R., Dhaval P. Bhatt, Thomas M. O’Connell, J Will Thompson, Laura G. Dubois, Donald S. Backos, Hao Yang, et al. “A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation.” Cell Metab 25, no. 4 (April 4, 2017): 823-837.e8. https://doi.org/10.1016/j.cmet.2017.03.006.

PMID
28380375
Full Text

McDonnell, Eoin, Scott B. Crown, Douglas B. Fox, Betül Kitir, Olga R. Ilkayeva, Christian A. Olsen, Paul A. Grimsrud, and Matthew D. Hirschey. “Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation.” Cell Rep 17, no. 6 (November 1, 2016): 1463–72. https://doi.org/10.1016/j.celrep.2016.10.012.

PMID
27806287
Full Text

Davies, Michael N., Lilja Kjalarsdottir, J Will Thompson, Laura G. Dubois, Robert D. Stevens, Olga R. Ilkayeva, M Julia Brosnan, Timothy P. Rolph, Paul A. Grimsrud, and Deborah M. Muoio. “The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins.” Cell Rep 14, no. 2 (January 12, 2016): 243–54. https://doi.org/10.1016/j.celrep.2015.12.030.

PMID
26748706
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Dingley, Stephen D., Erzsebet Polyak, Julian Ostrovsky, Satish Srinivasan, Icksoo Lee, Amy B. Rosenfeld, Mai Tsukikawa, et al. “Mitochondrial DNA variant in COX1 subunit significantly alters energy metabolism of geographically divergent wild isolates in Caenorhabditis elegans.” J Mol Biol 426, no. 11 (May 29, 2014): 2199–2216. https://doi.org/10.1016/j.jmb.2014.02.009.

PMID
24534730
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Still, Amelia J., Brendan J. Floyd, Alexander S. Hebert, Craig A. Bingman, Joshua J. Carson, Drew R. Gunderson, Brendan K. Dolan, et al. “Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.” J Biol Chem 288, no. 36 (September 6, 2013): 26209–19. https://doi.org/10.1074/jbc.M113.483396.

PMID
23864654
Full Text

Pages