Paul Grimsrud, PhD

Assistant Professor in Medicine
Member of Duke Molecular Physiology Institute
Campus mail 104775, Durham, NC 27701
Phone (919) 684-0631
Email address

Paul Grimsrud is an Assistant professor of Medicine—in the Division of Endocrinology, Metabolism, and Nutrition—and Proteomics Section Leader at the Duke Molecular Physiology Institute. He completed a PhD in Biochemistry at the University of Minnesota-Twin Cities and a postdoctoral fellowship at the University of Wisconsin-Madison. His research combines mass spectrometry-based proteomics with complementary biochemical approaches to characterize the regulation of metabolism and signaling by protein post-translational modifications (PTMs). He is particularly interested in mechanisms that link altered mitochondrial function to metabolic diseases, such as heart failure, type 2 diabetes, and cancer. He works with colleagues to apply quantitative PTM measurements to relevant model systems, leverage bioinformatics tools to develop testable hypotheses from large-scale data, and characterize mechanisms of PTM-mediated metabolic control.

Education and Training

  • Ph.D., University of Minnesota, Twin Cities, 2008


Grimsrud, Paul A., Matthew J. Picklo, Timothy J. Griffin, and David A. Bernlohr. “Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal.” Mol Cell Proteomics 6, no. 4 (April 2007): 624–37.

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Pearson, Arwen R., Teresa De La Mora-Rey, M Elizabeth Graichen, Yongting Wang, Limei H. Jones, Sudha Marimanikkupam, Sean A. Agger, Paul A. Grimsrud, Victor L. Davidson, and Carrie M. Wilmot. “Further insights into quinone cofactor biogenesis: probing the role of mauG in methylamine dehydrogenase tryptophan tryptophylquinone formation.” Biochemistry 43, no. 18 (May 11, 2004): 5494–5502.

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