Paul Michael Yen, MD

Professor of Medicine
Member of Duke Molecular Physiology Institute
Campus mail 300 North Duke Street, Durham, NC 27701
Phone (919) 479-2300
Email address paul.yen@duke-nus.edu.sg

Education and Training

  • Clinical Staff Fellow, Endocrinology, National Institutes of Health, 1988 - 1989
  • Resident, Medicine, University of Chicago, 1982 - 1985
  • M.D., Johns Hopkins University, 1982

Publications

Singh, BK, Sinha, RA, and Yen, PM. "Novel Transcriptional Mechanisms for Regulating Metabolism by Thyroid Hormone." International Journal of Molecular Sciences 19, no. 10 (October 22, 2018). (Review)

PMID
30360449
Full Text

Yau, WW, Singh, BK, Lesmana, R, Zhou, J, Sinha, RA, Wong, KA, Wu, Y, Bay, B-H, Sugii, S, Sun, L, and Yen, PM. "Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy." Autophagy (September 13, 2018): 1-20.

PMID
30209975
Full Text

Bruinstroop, E, Dalan, R, Cao, Y, Bee, YM, Chandran, K, Cho, LW, Soh, SB, Teo, EK, Toh, S-A, Leow, MKS, Sinha, RA, Sadananthan, SA, Michael, N, Stapleton, HM, Leung, C, Angus, PW, Patel, SK, Burrell, LM, Lim, SC, Sum, CF, Velan, SS, and Yen, PM. "Low-Dose Levothyroxine Reduces Intrahepatic Lipid Content in Patients With Type 2 Diabetes Mellitus and NAFLD." The Journal of Clinical Endocrinology and Metabolism 103, no. 7 (July 2018): 2698-2706.

PMID
29718334
Full Text

Singh, BK, Sinha, RA, Tripathi, M, Mendoza, A, Ohba, K, Sy, JAC, Xie, SY, Zhou, J, Ho, JP, Chang, C-Y, Wu, Y, Giguère, V, Bay, B-H, Vanacker, J-M, Ghosh, S, Gauthier, K, Hollenberg, AN, McDonnell, DP, and Yen, PM. "Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function." Science Signaling 11, no. 536 (June 26, 2018).

PMID
29945885
Full Text

Sinha, RA, Singh, BK, and Yen, PM. "Direct effects of thyroid hormones on hepatic lipid metabolism." Nature Reviews. Endocrinology 14, no. 5 (May 2018): 259-269. (Review)

PMID
29472712
Full Text

Zhou, J, Sinha, RA, Lesmana, R, Yau, WWY, and Yen, PM. "Pharmacological Inhibition of Lysosomal Activity as a Method For Monitoring Thyroid Hormone-induced Autophagic Flux in Mammalian Cells In Vitro." Methods in Molecular Biology (Clifton, N.J.) 1801 (January 2018): 111-122.

PMID
29892821
Full Text

Singh, BK, Sinha, RA, Ohba, K, and Yen, PM. "Role of thyroid hormone in hepatic gene regulation, chromatin remodeling, and autophagy." Molecular and Cellular Endocrinology 458 (December 2017): 160-168. (Review)

PMID
28216439
Full Text

Farah, BL, Landau, DJ, Wu, Y, Sinha, RA, Loh, A, Bay, B-H, Koeberl, DD, and Yen, PM. "Renal endoplasmic reticulum stress is coupled to impaired autophagy in a mouse model of GSD Ia." Molecular Genetics and Metabolism 122, no. 3 (November 2017): 95-98.

PMID
28888852
Full Text

Wang, M-E, Singh, BK, Hsu, M-C, Huang, C, Yen, PM, Wu, L-S, Jong, D-S, and Chiu, C-H. "Increasing Dietary Medium-Chain Fatty Acid Ratio Mitigates High-fat Diet-Induced Non-Alcoholic Steatohepatitis by Regulating Autophagy." Scientific Reports 7, no. 1 (October 25, 2017): 13999-null.

PMID
29070903
Full Text

Flamant, F, Cheng, S-Y, Hollenberg, AN, Moeller, LC, Samarut, J, Wondisford, FE, Yen, PM, and Refetoff, S. "Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature." Endocrinology 158, no. 7 (July 2017): 2052-2057.

PMID
28472304
Full Text

Pages