Education and Training
- Clinical Staff Fellow, Endocrinology, National Institutes of Health, 1988 - 1989
- Resident, Medicine, University of Chicago, 1982 - 1985
- M.D., Johns Hopkins University, 1982
Yau, WW, Singh, BK, Lesmana, R, Zhou, J, Sinha, RA, Wong, KA, Wu, Y, Bay, B-H, Sugii, S, Sun, L, and Yen, PM. "Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy." Autophagy 15, no. 1 (January 2019): 131-150.
Singh, BK, Sinha, RA, and Yen, PM. "Novel Transcriptional Mechanisms for Regulating Metabolism by Thyroid Hormone." International Journal of Molecular Sciences 19, no. 10 (October 22, 2018). (Review)
Bruinstroop, E, Dalan, R, Cao, Y, Bee, YM, Chandran, K, Cho, LW, Soh, SB, Teo, EK, Toh, S-A, Leow, MKS, Sinha, RA, Sadananthan, SA, Michael, N, Stapleton, HM, Leung, C, Angus, PW, Patel, SK, Burrell, LM, Lim, SC, Sum, CF, Velan, SS, and Yen, PM. "Low-Dose Levothyroxine Reduces Intrahepatic Lipid Content in Patients With Type 2 Diabetes Mellitus and NAFLD." The Journal of Clinical Endocrinology and Metabolism 103, no. 7 (July 2018): 2698-2706.
Singh, BK, Sinha, RA, Tripathi, M, Mendoza, A, Ohba, K, Sy, JAC, Xie, SY, Zhou, J, Ho, JP, Chang, C-Y, Wu, Y, Giguère, V, Bay, B-H, Vanacker, J-M, Ghosh, S, Gauthier, K, Hollenberg, AN, McDonnell, DP, and Yen, PM. "Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function." Science Signaling 11, no. 536 (June 26, 2018).
Sinha, RA, Singh, BK, and Yen, PM. "Direct effects of thyroid hormones on hepatic lipid metabolism." Nature Reviews. Endocrinology 14, no. 5 (May 2018): 259-269. (Review)
Zhou, J, Sinha, RA, Lesmana, R, Yau, WWY, and Yen, PM. "Pharmacological Inhibition of Lysosomal Activity as a Method For Monitoring Thyroid Hormone-induced Autophagic Flux in Mammalian Cells In Vitro." Methods in Molecular Biology (Clifton, N.J.) 1801 (January 2018): 111-122.
Singh, BK, Sinha, RA, Ohba, K, and Yen, PM. "Role of thyroid hormone in hepatic gene regulation, chromatin remodeling, and autophagy." Molecular and Cellular Endocrinology 458 (December 2017): 160-168. (Review)
Farah, BL, Landau, DJ, Wu, Y, Sinha, RA, Loh, A, Bay, B-H, Koeberl, DD, and Yen, PM. "Renal endoplasmic reticulum stress is coupled to impaired autophagy in a mouse model of GSD Ia." Molecular Genetics and Metabolism 122, no. 3 (November 2017): 95-98.
Wang, M-E, Singh, BK, Hsu, M-C, Huang, C, Yen, PM, Wu, L-S, Jong, D-S, and Chiu, C-H. "Increasing Dietary Medium-Chain Fatty Acid Ratio Mitigates High-fat Diet-Induced Non-Alcoholic Steatohepatitis by Regulating Autophagy." Scientific Reports 7, no. 1 (October 25, 2017): 13999-null.
Flamant, F, Cheng, S-Y, Hollenberg, AN, Moeller, LC, Samarut, J, Wondisford, FE, Yen, PM, and Refetoff, S. "Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature." Endocrinology 158, no. 7 (July 2017): 2052-2057.