Paul Michael Yen, MD

Professor of Medicine
Campus mail 300 North Duke Street, Durham, NC 27701
Phone (919) 479-2300
Email address paul.yen@duke-nus.edu.sg

Education and Training

  • Clinical Staff Fellow, Endocrinology, National Institutes of Health, 1988 - 1989
  • Resident, Medicine, University of Chicago, 1982 - 1985
  • M.D., Johns Hopkins University, 1982

Publications

Singh, BK, Sinha, RA, Ohba, K, and Yen, PM. "Role of thyroid hormone in hepatic gene regulation, chromatin remodeling, and autophagy." Molecular and cellular endocrinology 458 (December 2017): 160-168.

PMID
28216439
Full Text

Farah, BL, Landau, DJ, Wu, Y, Sinha, RA, Loh, A, Bay, B-H, Koeberl, DD, and Yen, PM. "Renal endoplasmic reticulum stress is coupled to impaired autophagy in a mouse model of GSD Ia." Molecular genetics and metabolism 122, no. 3 (November 2017): 95-98.

PMID
28888852
Full Text

Wang, M-E, Singh, BK, Hsu, M-C, Huang, C, Yen, PM, Wu, L-S, Jong, D-S, and Chiu, C-H. "Increasing Dietary Medium-Chain Fatty Acid Ratio Mitigates High-fat Diet-Induced Non-Alcoholic Steatohepatitis by Regulating Autophagy." Scientific reports 7, no. 1 (October 25, 2017): 13999-.

PMID
29070903
Full Text

Flamant, F, Cheng, S-Y, Hollenberg, AN, Moeller, LC, Samarut, J, Wondisford, FE, Yen, PM, and Refetoff, S. "Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature." Endocrinology 158, no. 7 (July 2017): 2052-2057.

PMID
28472304
Full Text

Ohba, K, Sinha, RA, Singh, BK, Iannucci, LF, Zhou, J, Kovalik, J-P, Liao, X-H, Refetoff, S, Sng, JCG, Leow, MK-S, and Yen, PM. "Changes in Hepatic TRβ Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model." Thyroid : official journal of the American Thyroid Association 27, no. 6 (June 2017): 852-860.

PMID
28457184
Full Text

Iannucci, LF, Cioffi, F, Senese, R, Goglia, F, Lanni, A, Yen, PM, and Sinha, RA. "Metabolomic analysis shows differential hepatic effects of T2 and T3 in rats after short-term feeding with high fat diet." Scientific reports 7, no. 1 (May 17, 2017): 2023-.

PMID
28515456
Full Text

Farah, BL, Sinha, RA, Wu, Y, Singh, BK, Lim, A, Hirayama, M, Landau, DJ, Bay, BH, Koeberl, DD, and Yen, PM. "Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa)." Scientific reports 7 (March 20, 2017): 44408-.

PMID
28317891
Full Text

Zhou, J, Chong, SY, Lim, A, Singh, BK, Sinha, RA, Salmon, AB, and Yen, PM. "Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging." Aging 9, no. 2 (February 26, 2017): 583-599.

PMID
28238968
Full Text

Sinha, RA, Singh, BK, and Yen, PM. "Reciprocal Crosstalk Between Autophagic and Endocrine Signaling in Metabolic Homeostasis." Endocrine reviews 38, no. 1 (February 2017): 69-102. (Review)

PMID
27901588
Full Text

Sinha, RA, Singh, BK, Zhou, J, Xie, S, Farah, BL, Lesmana, R, Ohba, K, Tripathi, M, Ghosh, S, Hollenberg, AN, and Yen, PM. "Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells." Autophagy 13, no. 1 (January 2017): 169-186.

PMID
27846372
Full Text

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