Redford B. Williams, MD

Professor of Psychiatry and Behavioral Sciences
Professor of Psychology and Neuroscience
Professor of Medicine
Campus mail 905 W. Main Street, Suite 22 (2nd Floor), Durham, NC 27701
Phone (919) 684-3863
Email address redfordw@duke.edu

My research aims to identify psychosocial factors that are involved in the pathogenesis and course of major medical disorders, to characterize the biobehavioral mechanisms whereby such factors influence disease, and to develop both behavioral and pharmacologic means of preventing or ameliorating the adverse impact of psychosocial factors on health and disease. Specific projects that are currently active include: 1) The influence of hostile personality, social isolation, depression and other psychosocial risk factors upon the development and course of cardiometabolic disease; 2) Biological and genetic mechanisms whereby psychosocial risk factors influence disease development and course; and 3) Behavioral and pharmacologic approaches to ameliorate impact of psychosocial risk factors on disease risk and course.

Education and Training

  • M.D., Yale University, 1967

Publications

Brummett, Beverly H., Michael A. Babyak, Abanish Singh, Elizabeth R. Hauser, Rong Jiang, Kim M. Huffman, William E. Kraus, Svati H. Shah, Ilene C. Siegler, and Redford B. Williams. “Lack of Association of a Functional Polymorphism in the Serotonin Receptor Gene With Body Mass Index and Depressive Symptoms in a Large Meta-Analysis of Population Based Studies..” Front Genet 9 (2018). https://doi.org/10.3389/fgene.2018.00423.

PMID
30333852
Full Text

Jiang, Rong, Michael A. Babyak, Beverly H. Brummett, Elizabeth R. Hauser, Brett C. Haberstick, Andrew Smolen, Ilene C. Siegler, Kathleen Mullan Harris, and Redford B. Williams. “Gender Differences in Brain-Derived Neurotrophic Factor (BDNF) Val66Met Variants and Stressful Life Events on Psychological and Metabolic Phenotypes.” In Genetic Epidemiology, 41:665–665. WILEY, 2017.

Scholars@Duke

Jiang, Rong, Michael A. Babyak, Beverly H. Brummett, Elizabeth R. Hauser, Abanish Singh, Ilene C. Siegler, and Redford B. Williams. “The effect of Brain- Derived Neurotrophic Factor (BDNF) Val66Met Variants on the Path from Psychosocial Stress to Depression, Body Mass Index and Pre-Clinical Atherosclerosis.” In Genetic Epidemiology, 41:665–66. WILEY, 2017.

Scholars@Duke

Proeschold-Bell, Rae Jean, Elizabeth L. Turner, Gary G. Bennett, Jia Yao, Xiang-Fang Li, David E. Eagle, Rachel A. Meyer, et al. “A 2-Year Holistic Health and Stress Intervention: Results of an RCT in Clergy..” Am J Prev Med 53, no. 3 (September 2017): 290–99. https://doi.org/10.1016/j.amepre.2017.04.009.

PMID
28641912
Full Text

Jiang, Rong, Michael A. Babyak, Beverly H. Brummett, Elizabeth R. Hauser, Svati H. Shah, Richard C. Becker, Ilene C. Siegler, et al. “Brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism is associated with disease severity and incidence of cardiovascular events in a patient cohort..” Am Heart J 190 (August 2017): 40–45. https://doi.org/10.1016/j.ahj.2017.05.002.

PMID
28760212
Full Text

Jiang, Rong, Michael A. Babyak, Beverly H. Brummett, Ilene C. Siegler, Cynthia M. Kuhn, and Redford B. Williams. “Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress..” Psychoneuroendocrinology 79 (May 2017): 13–19. https://doi.org/10.1016/j.psyneuen.2017.02.005.

PMID
28249185
Full Text

Sun, Julia L., Stephen H. Boyle, Zainab Samad, Michael A. Babyak, Jennifer L. Wilson, Cynthia Kuhn, Richard C. Becker, et al. “Mental stress-induced left ventricular dysfunction and adverse outcome in ischemic heart disease patients..” Eur J Prev Cardiol 24, no. 6 (April 2017): 591–99. https://doi.org/10.1177/2047487316686435.

PMID
28067532
Full Text

Williams, Redford B., George D. Bishop, Brett C. Haberstick, Andrew Smolen, Beverly H. Brummett, Ilene C. Siegler, Michael A. Babyak, et al. “Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence..” Am Heart J 185 (March 2017): 110–22. https://doi.org/10.1016/j.ahj.2016.12.013.

PMID
28267464
Full Text

Feigal, Jacob P., Stephen H. Boyle, Zainab Samad, Eric J. Velazquez, Jennifer L. Wilson, Richard C. Becker, Redford B. Williams, et al. “Associations between positive emotional well-being and stress-induced myocardial ischemia: Well-being scores predict exercise-induced ischemia..” J Psychosom Res 93 (February 2017): 14–18. https://doi.org/10.1016/j.jpsychores.2016.11.012.

PMID
28107887
Full Text

Pages