Redford B. Williams, MD

Professor of Psychiatry and Behavioral Sciences
Professor of Psychology and Neuroscience
Professor of Medicine
Campus mail 5811 Buck Quarter Road, Hillsborough, NC 27278
Phone (919) 684-3863
Email address redfordw@duke.edu

My research aims to identify psychosocial factors that are involved in the pathogenesis and course of major medical disorders, to characterize the biobehavioral mechanisms whereby such factors influence disease, and to develop both behavioral and pharmacologic means of preventing or ameliorating the adverse impact of psychosocial factors on health and disease. Specific projects that are currently active include: 1) The influence of hostile personality, social isolation, depression and other psychosocial risk factors upon the development and course of cardiometabolic disease; 2) Biological and genetic mechanisms whereby psychosocial risk factors influence disease development and course; and 3) Behavioral and pharmacologic approaches to ameliorate impact of psychosocial risk factors on disease risk and course.

Education and Training

  • M.D., Yale University, 1967

Publications

Jiang, Wei, Eric J. Velazquez, Maragatha Kuchibhatla, Zainab Samad, Stephen H. Boyle, Cynthia Kuhn, Richard C. Becker, et al. “Effect of escitalopram on mental stress-induced myocardial ischemia: results of the REMIT trial.” Jama 309, no. 20 (May 2013): 2139–49. https://doi.org/10.1001/jama.2013.5566.

PMID
23695483
Full Text

Brummett, B. H., Michael A. Babyak, Rong Jiang, Abanish Singh, Redford B. Williams, Kathleen M. Harris, and Ilene C. Siegler. “BIOBEHAVIORAL MEDIATORS OF SES EFFECTS ON CRP IN A NATIONALLY REPRESENTATIVE US SAMPLE.” In Psychosomatic Medicine, 75:A70–71. LIPPINCOTT WILLIAMS & WILKINS, 2013.

Scholars@Duke

Williams, Redford B., George D. Bishop, Brett C. Haberstick, Andrew Smolen, Michael J. Helms, Beverly H. Brummett, Ilene C. Siegler, et al. “POPULATION DIFFERENCES IN ASSOCIATIONS OF SEROTONIN TRANSPORTER PROMOTER POLYMORPHISM (5HTTLPR) DI- AND TRIALLELIC GENOTYPES WITH BLOOD PRESSURE AND HYPERTENSION PREVALENCE.” In Psychosomatic Medicine, 75:A64–A64. LIPPINCOTT WILLIAMS & WILKINS, 2013.

Scholars@Duke

Babyak, Michael A., Richard C. Becker, Michael J. Helms, Rong Jiang, Abanish Singh, Beverly H. Brummett, Ilene C. Siegler, Allison Ashley-Koch, Thomas Ortel, and Redford B. Williams. “ADRENERGIC GENE VARIANTS ARE ASSOCIATED WITH PLATELET AGGREGATION TO EPINEPHRINE.” In Psychosomatic Medicine, 75:A87–A87. LIPPINCOTT WILLIAMS & WILKINS, 2013.

Scholars@Duke

Lane, James D., Cynthia M. Kuhn, Richard S. Surwit, Ilene C. Siegler, Beverly H. Brummett, and Redford B. Williams. “BLOOD PRESSURE 'NON-DIPPING' STATUS IS ASSOCIATED WITH GREATER OVERNIGHT EPINEPHRINE EXCRETION.” In Psychosomatic Medicine, 75:A31–A31. LIPPINCOTT WILLIAMS & WILKINS, 2013.

Scholars@Duke

Georgiades, Anastasia, Beverly H. Brummett, Ilene C. Siegler, Richard S. Surwit, Cynthia Kuhn, Katherine Grichnik, Mark Stafford-Smith, and Redford B. Williams. “EFFECT OF CENTRAL NERVOUS SYSTEM SEROTONIN FUNCTION ON INFLAMMATION, ADIPOSITY AND INSULIN SENSITIVITY.” In Psychosomatic Medicine, 75:A69–A69. LIPPINCOTT WILLIAMS & WILKINS, 2013.

Scholars@Duke

Jiang, Rong, Beverly H. Brummett, Elizabeth R. Hauser, Michael A. Babyak, Ilene C. Siegler, Abanish Singh, Arne Astrup, et al. “Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples.” Biol Psychol 93, no. 1 (April 2013): 184–89. https://doi.org/10.1016/j.biopsycho.2013.02.006.

PMID
23435269
Full Text

Jiang, Rong, Beverly H. Brummett, Michael A. Babyak, Ilene C. Siegler, and Redford B. Williams. “Brain-derived neurotrophic factor (BDNF) Val66Met and adulthood chronic stress interact to affect depressive symptoms.” J Psychiatr Res 47, no. 2 (February 2013): 233–39. https://doi.org/10.1016/j.jpsychires.2012.10.009.

PMID
23140671
Full Text

Jiang, Wei, Zainab Samad, Stephen Boyle, Richard C. Becker, Redford Williams, Cynthia Kuhn, Thomas L. Ortel, et al. “Prevalence and clinical characteristics of mental stress-induced myocardial ischemia in patients with coronary heart disease.” Journal of the American College of Cardiology 61, no. 7 (February 2013): 714–22. https://doi.org/10.1016/j.jacc.2012.11.037.

PMID
23410543
Full Text

Brummett, Beverly H., Shirley B. Austin, Kathleen A. Welsh-Bohmer, Redford B. Williams, and Ilene C. Siegler. “Long-Term Impact of Caregiving and Metabolic Syndrome with Perceived Decline in Cognitive Function 8 Years Later: A Pilot Study Suggesting Important Avenues for Future Research.” Open J Med Psychol 2, no. 1 (January 2013): 23–28. https://doi.org/10.4236/ojmp.2013.21005.

PMID
24634805
Full Text

Pages