Robert John Mentz, MD

Associate Professor of Medicine
Associate Professor in Population Health Sciences
Member in the Duke Clinical Research Institute
Campus mail Np-8062, Dcri. PO Box 17969, Durham, NC 27715
Phone (919) 668-7121
Email address

I am a cardiologist with a clinical and research interest in heart failure, including advanced therapies such as cardiac transplantation and mechanical assist devices or “heart pumps." I serve our group as Chief of the Heart Failure Section. I became a heart failure cardiologist in order to help patients manage their chronic disease over many months and years. I consider myself strongly committed to compassionate patient care with a focus on quality of life and patient preference.

My research interests are focused on treating co-morbid diseases in heart failure patients and improving outcomes across the cardiovascular spectrum through clinical trials and outcomes research. Below, you will find my specific research interests:

  •     Cardiometabolic disease
  •     Co-morbidity characterization (diabetes, sleep apnea, renal failure) in heart failure.
  •     Phenotypic characterization and risk prognostication of patients with heart failure.
  •     Role of surrogate and nonfatal endpoints in clinical heart failure trials.
  •     Biomarkers in heart failure.
  •     Novel pharmacological and non-pharmacological approaches to heart failure.
  •     Improving site-based heart failure research.
In Their Words

Education and Training

  • Fellowship, Advanced Heart Failure, Duke University School of Medicine, 2012 - 2013
  • Fellowship, Clinical Cardiology, Duke University School of Medicine, 2010 - 2012
  • Resident, Internal Medicine, Brigham and Women's Hospital, 2008 - 2010
  • Intern, Internal Medicine, Brigham and Women's Hospital, 2007 - 2008
  • M.D., Emory University, 2003


Pandey, Ambarish, Neil Keshvani, Colby Ayers, Adolfo Correa, Mark H. Drazner, Alana Lewis, Carlos J. Rodriguez, et al. “Association of Cardiac Injury and Malignant Left Ventricular Hypertrophy With Risk of Heart Failure in African Americans: The Jackson Heart Study.” Jama Cardiol 4, no. 1 (January 1, 2019): 51–58.

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Luo, Nancy, Christopher M. O’Connor, Lauren B. Cooper, Jie-Lena Sun, Adrian Coles, Shelby D. Reed, David J. Whellan, Ileana L. Piña, William E. Kraus, and Robert J. Mentz. “Relationship between changing patient-reported outcomes and subsequent clinical events in patients with chronic heart failure: insights from HF-ACTION.” Eur J Heart Fail 21, no. 1 (January 2019): 63–70.

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Warraich, Haider J., Donald H. Taylor, David J. Casarett, Marisette Hasan, Chetan B. Patel, Arif H. Kamal, Matthew Harker, and Robert J. Mentz. “Hospice Care for Heart Failure: Challenges Faced by Hospice Staff in a Predominantly Rural Setting.” J Palliat Med 22, no. 1 (January 2019): 7–8.

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Eisenstein, Eric L., Kristi Prather, Stephen J. Greene, Tina Harding, Amanda Harrington, Davera Gabriel, Ingrid Jones, Robert J. Mentz, Eric J. Velazquez, and Kevin J. Anstrom. “Death: The Simple Clinical Trial Endpoint.” Stud Health Technol Inform 257 (2019): 86–91.


Fudim, Marat, Andrew P. Ambrosy, Jie-Lena Sun, Kevin J. Anstrom, Bradley A. Bart, Javed Butler, Omar AbouEzzeddine, et al. “High-Sensitivity Troponin I in Hospitalized and Ambulatory Patients With Heart Failure With Preserved Ejection Fraction: Insights From the Heart Failure Clinical Research Network.” In J Am Heart Assoc, 7:e010364, 2018.

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Inohara, Taku, Pratik Manandhar, Andrzej S. Kosinski, Roland A. Matsouaka, Shun Kohsaka, Robert J. Mentz, Vinod H. Thourani, et al. “Association of Renin-Angiotensin Inhibitor Treatment With Mortality and Heart Failure Readmission in Patients With Transcatheter Aortic Valve Replacement.” Jama 320, no. 21 (December 4, 2018): 2231–41.

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Sharma, Abhinav, Andrew P. Ambrosy, Adam D. DeVore, Kenneth B. Margulies, Steven E. McNulty, Robert J. Mentz, Adrian F. Hernandez, et al. “Liraglutide and weight loss among patients with advanced heart failure and a reduced ejection fraction: insights from the FIGHT trial.” In Esc Heart Fail, 5:1035–43, 2018.

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Mediano, Mauro F. F., Eric S. Leifer, Lawton S. Cooper, Steven J. Keteyian, William E. Kraus, Robert J. Mentz, and Jerome L. Fleg. “Influence of Baseline Physical Activity Level on Exercise Training Response and Clinical Outcomes in Heart Failure: The HF-ACTION Trial.” Jacc Heart Fail 6, no. 12 (December 2018): 1011–19.

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Schwartz, Gregory G., P Gabriel Steg, Michael Szarek, Deepak L. Bhatt, Vera A. Bittner, Rafael Diaz, Jay M. Edelberg, et al. “Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome.” N Engl J Med 379, no. 22 (November 29, 2018): 2097–2107.

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