Robert John Mentz, MD

Associate Professor of Medicine
Associate Professor in Population Health Sciences
Member in the Duke Clinical Research Institute
Campus mail Np-8062, Dcri. PO Box 17969, Durham, NC 27715
Phone (919) 668-7121
Email address

I am a cardiologist with a clinical and research interest in heart failure, including advanced therapies such as cardiac transplantation and mechanical assist devices or “heart pumps." I became a heart failure cardiologist in order to help patients manage their chronic disease over many months and years. I consider myself strongly committed to compassionate patient care with a focus on quality of life and patient preference.

My research interests are focused on treating co-morbid diseases in heart failure patients and improving outcomes across the cardiovascular spectrum through clinical trials and outcomes research. Below, you will find my specific research interests:

  •     Co-morbidity characterization (diabetes, sleep apnea, renal failure) in heart failure.
  •     Phenotypic characterization and risk prognostication of patients with heart failure.
  •     Role of surrogate and nonfatal endpoints in clinical heart failure trials.
  •     Biomarkers in heart failure.
  •     Novel pharmacological and non-pharmacological approaches to heart failure.
  •     Improving site-based heart failure research.
In Their Words

Education and Training

  • Fellowship, Advanced Heart Failure, Duke University School of Medicine, 2012 - 2013
  • Fellowship, Clinical Cardiology, Duke University School of Medicine, 2010 - 2012
  • Resident, Internal Medicine, Brigham and Women's Hospital, 2008 - 2010
  • Intern, Internal Medicine, Brigham and Women's Hospital, 2007 - 2008
  • M.D., Emory University, 2003


Greene, Stephen J., Emily C. O’Brien, Robert J. Mentz, Nancy Luo, N Chantelle Hardy, Warren K. Laskey, Paul A. Heidenreich, et al. “Home-Time After Discharge Among Patients Hospitalized With Heart Failure..” J Am Coll Cardiol 71, no. 23 (June 12, 2018): 2643–52.

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Ambrosy, Andrew P., Robert J. Mentz, Mona Fiuzat, John G. F. Cleland, Stephen J. Greene, Christopher M. O’Connor, John R. Teerlink, Faiez Zannad, and Scott D. Solomon. “The role of angiotensin receptor-neprilysin inhibitors in cardiovascular disease-existing evidence, knowledge gaps, and future directions..” Eur J Heart Fail 20, no. 6 (June 2018): 963–72.

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Luo, Nancy, Nicholas G. Ballew, Emily C. O’Brien, Melissa A. Greiner, Pamela N. Peterson, Bradley G. Hammill, N Chantelle Hardy, et al. “Early impact of guideline publication on angiotensin-receptor neprilysin inhibitor use among patients hospitalized for heart failure..” Am Heart J 200 (June 2018): 134–40.

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Mentz, Robert J., Melissa A. Greiner, Paul Muntner, Daichi Shimbo, Mario Sims, Tanya M. Spruill, Benjamin F. Banahan, et al. “Intentional and unintentional medication non-adherence in African Americans: Insights from the Jackson Heart Study..” Am Heart J 200 (June 2018): 51–59.

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Fudim, M Marat, S. J. Doerfler, A. Coles, S. J. Greene, L. B. Cooper, M. Fiuzat, C. M. O’connor, J. G. Rogers, and R. J. Mentz. “Worsening renal function during decongestion among patients hospitalized for heart failure: findings from the escape trial.” In European Journal of Heart Failure, 20:548–548. WILEY, 2018.


Teng, Tiew-Hwa Katherine, W. T. Tay, N. Luo, L. B. Cooper, J. Tromp, W. Kraus, D. Whellan, et al. “Association of body surface area with target dose guideline-directed therapy in an international cohort of patients with heart failure.” In European Journal of Heart Failure, 20:257–58. WILEY, 2018.


Warraich, Haider J., Di Lu, Stacy Cobb, Lauren B. Cooper, Adam DeVore, Chetan B. Patel, Paul B. Rosenberg, et al. “Trends and outcomes of cardiac transplantation from donors dying of drug intoxication..” Am Heart J 199 (May 2018): 92–96.

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Ambrosy, Andrew P., Ankeet S. Bhatt, Amanda L. Stebbins, Lisa M. Wruck, Marat Fudim, Stephen J. Greene, William E. Kraus, et al. “Prevalent digoxin use and subsequent risk of death or hospitalization in ambulatory heart failure patients with a reduced ejection fraction-Findings from the Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) randomized controlled trial..” Am Heart J 199 (May 2018): 97–104.

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