Rodger Alan Liddle, MD

Professor of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Campus mail 1033A GSRB-1 Bldg, Durham, NC 27710
Phone (919) 681-6380
Email address rodger.liddle@duke.edu

Our laboratory has two major research interests:

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’.  Our laboratory is devoted to understanding EECs signaling and its role in disease.

Pancreatitis

Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes.  Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis. 

Visit our lab page.

Education and Training

  • Gastroenterology Fellowship, Gastroenterology, University of California - San Francisco, 1981 - 1984
  • Residency, Generalinternal Medicine, University of California - San Francisco, 1979 - 1981
  • Internship, General Internal Medicine, University of California - San Francisco, 1978 - 1979
  • M.D., Vanderbilt University, 1978
  • B.S., University of Utah, 1972

Publications

Kanju, Patrick, Yong Chen, Whasil Lee, Michele Yeo, Suk Hee Lee, Joelle Romac, Rafiq Shahid, et al. “Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain..” Sci Rep 6 (June 1, 2016). https://doi.org/10.1038/srep26894.

PMID
27247148
Full Text

Anderson, Michelle A., Venkata Akshintala, Kathryn M. Albers, Stephen T. Amann, Inna Belfer, Randall Brand, Suresh Chari, et al. “Mechanism, assessment and management of pain in chronic pancreatitis: Recommendations of a multidisciplinary study group..” Pancreatology 16, no. 1 (January 2016): 83–94. https://doi.org/10.1016/j.pan.2015.10.015.

PMID
26620965
Full Text

Bohórquez, Diego, Fariha Haque, Satish Medicetty, and Rodger A. Liddle. “Correlative Confocal and 3D Electron Microscopy of a Specific Sensory Cell..” J Vis Exp, no. 101 (July 19, 2015). https://doi.org/10.3791/52918.

PMID
26273796
Full Text

Bohórquez, Diego V., and Rodger A. Liddle. “The gut connectome: making sense of what you eat..” J Clin Invest 125, no. 3 (March 2, 2015): 888–90. https://doi.org/10.1172/JCI81121.

PMID
25729849
Full Text

Shahid, Rafiq A., David Q-H Wang, Brian E. Fee, Shannon J. McCall, Joelle M-J Romac, Steven R. Vigna, and Rodger A. Liddle. “Endogenous elevation of plasma cholecystokinin does not prevent gallstones..” Eur J Clin Invest 45, no. 3 (March 2015): 237–46. https://doi.org/10.1111/eci.12400.

PMID
25641074
Full Text

Morozko, Eva L., Ayako Nishio, Neil J. Ingham, Rashmi Chandra, Tracy Fitzgerald, Elisa Martelletti, Guntram Borck, et al. “ILDR1 null mice, a model of human deafness DFNB42, show structural aberrations of tricellular tight junctions and degeneration of auditory hair cells..” Hum Mol Genet 24, no. 3 (February 1, 2015): 609–24. https://doi.org/10.1093/hmg/ddu474.

PMID
25217574
Full Text

Bohórquez, Diego V., Rafiq A. Shahid, Alan Erdmann, Alex M. Kreger, Yu Wang, Nicole Calakos, Fan Wang, and Rodger A. Liddle. “Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells..” J Clin Invest 125, no. 2 (February 2015): 782–86. https://doi.org/10.1172/JCI78361.

PMID
25555217
Full Text

Pages